Longitudinal associations between inhibitory control and externalizing and internalizing symptoms in school-aged children

2020 ◽  
pp. 1-13
Author(s):  
Katri Maasalo ◽  
Jallu Lindblom ◽  
Olli Kiviruusu ◽  
Päivi Santalahti ◽  
Eeva T. Aronen

Abstract Inhibitory control (IC) deficits have been associated with psychiatric symptoms in all ages. However, longitudinal studies testing the direction of the associations in childhood are scarce. We used a sample of 2,874 children (7 to 9 years old) to test the following three hypotheses: (a) IC deficits are an underlying risk factor with a potentially causal role for psychopathology, (b) IC deficits are a complication of psychopathology, and (c) IC deficits and psychopathology are associated at the trait level but not necessarily causally related. We used the go/no-go task to assess IC, the parent-rated Strengths and Difficulties Questionnaire to evaluate externalizing/internalizing symptoms, and the random intercepts cross-lagged panel model to test the hypotheses. The results showed no support for the underlying risk factor hypothesis, suggesting that IC unlikely has a causal role in this age group's psychopathology. The complication hypothesis received support for externalizing symptoms, suggesting that externalizing symptoms may hamper the normal development of IC. IC deficits and both externalizing and internalizing symptoms were correlated at the trait level, indicating a possible common origin. We suggest that it may be useful to support children with externalizing symptoms to promote and protect their IC development.

2011 ◽  
Vol 22 (3) ◽  
pp. 219-246
Author(s):  
KRISTEN E BOYLE ◽  
JACOB E FRIEDMAN

The most common maternal risk factor associated with neonatal complications during delivery is obesity. Although gestational diabetes mellitus (GDM) occurs in 5–10% of the pregnant population, obesity, by virtue of its prevalence, far outpaces GDM as the most important underlying risk factor for increased fetal adiposity. The mechanisms underlying maternal insulin resistance may play an important role in the diversion of excess fuels to the fetus. Maternal adipose depots increase in early pregnancy, followed by increased adipose tissue lipolysis and subsequent hyperlipidaemia, which mainly corresponds to increased triglyceride levels (TG). A positive correlation between maternal TG and infant body weight or fat mass has been found in both GDM and non-GDM obese women. Increased oxidative stress, altered adipokines, and inflammatory cytokines have also been found in obese pregnant women, suggesting an adverse metabolic outcome even in normoglycemic conditions.


2020 ◽  
Vol 67 (8) ◽  
Author(s):  
Aaqib Zaffar Banday ◽  
Reva Tyagi ◽  
Suchit Jogu ◽  
Murugan Sudhakar ◽  
Pratap Kumar Patra ◽  
...  

2007 ◽  
Vol 68 (1) ◽  
pp. 228-229 ◽  
Author(s):  
Jannis Kountouras ◽  
Christos Zavos ◽  
Emmanuel Gavalas ◽  
Marina Boziki ◽  
Dimitrios Chatzopoulos ◽  
...  

2015 ◽  
Vol 73 (1) ◽  
pp. 72-72
Author(s):  
Gustavo Bruniera Peres Fernandes ◽  
Sergio Tufik ◽  
Fernando Morgadinho Santos Coelho

2019 ◽  
Author(s):  
Marieke S. Tollenaar ◽  
Roseriet Beijers ◽  
Elika Garg ◽  
T.T. Thao Nguyen ◽  
David T.S. Lin ◽  
...  

AbstractChildhood psychiatric symptoms may be associated with advanced biological aging. This study examined whether epigenetic age acceleration (EAA) associates with internalizing and externalizing symptoms across childhood in a longitudinal cohort study. At age 6 buccal epithelial cells from 148 children (69 girls) were collected to survey genome-wide DNA methylation. EAA was estimated using the Horvath clock. Internalizing symptoms at ages 2.5 and 4 years significantly predicted higher EAA at age 6, which in turn was significantly associated with internalizing symptoms from ages 6 to 10 years. Similar trends for externalizing symptoms did not reach significance. These findings indicate advanced biological aging in relation to child mental health and may help better identify those at risk for lasting impairments associated with internalizing disorders.


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