Prevalence and correlates of psychotropic drug use in community-dwelling people with young-onset dementia: the NeedYD-study

2014 ◽  
Vol 26 (12) ◽  
pp. 1983-1989 ◽  
Author(s):  
Raymond T.C.M. Koopmans ◽  
Renate Reinders ◽  
Deliane van Vliet ◽  
Frans R.J. Verhey ◽  
Marjolein E. de Vugt ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Unmet Needs ◽  
Community Dwelling ◽  
Young Onset ◽  
Disease Awareness ◽  
Psychotropic Drug Use ◽  
Young Onset Dementia

ABSTRACTBackground:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investigate psychotropic drug use (PDU) in Dutch community-dwelling YOD patients and the association between age, gender, dementia etiology and severity, symptoms of depression, disease awareness, unmet needs, and type of NPS.Methods:Psychotropic drug use in 196 YOD patients was registered. Drugs were categorized according to the Anatomical Therapeutical Chemical classification. The association between age, gender, dementia type, dementia stage, type of NPS, depressive symptoms, disease awareness, and amount of unmet needs on total PDU was analyzed using binomial logistic regression analysis.Results:Fifty-two percent of the patients were prescribed at least one psychotropic drug; 36.2% of patients used one drug, and 12.2% used two different drugs. Antidepressants (36.2%) and antipsychotic drugs (17.3%) were the most frequently prescribed psychotropic drugs. Anti-dementia drugs were prescribed in 51.5% of the patients. Increasing age and moderate to severe depressive symptoms were positively associated with the total use of psychotropic drugs.Conclusions:Community-dwelling YOD patients have a high prevalence of PDU. More research is needed to study the association between unmet needs, NPS, and PDU, and psychosocial interventions have to be developed to limit the use of psychotropic drugs in YOD.

scholarly journals Psychotropic drug use in community-dwelling people with young-onset dementia: two-year course and determinants

2019 ◽  
Vol 25 (1) ◽  
pp. 179-186
Author(s):  
Adrie A. J. Gerritsen ◽  
Christian Bakker ◽  
Esther Bruls ◽  
Frans R. J. Verhey ◽  
Yolande A. L. Pijnenburg ◽  
...  
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Community Dwelling ◽  
Young Onset ◽  
Psychotropic Drug Use ◽  
Young Onset Dementia

scholarly journals Prevalence and correlates of psychotropic drug use in Dutch nursing home patients with young‐onset dementia

2019 ◽  
Vol 34 (8) ◽  
pp. 1185-1193 ◽  
Author(s):  
Ans J.M.J. Mulders ◽  
Sytse U. Zuidema ◽  
Renée Leeuwis ◽  
Hans Bor ◽  
Frans R.J. Verhey ◽  
...  
Keyword(s):  
Nursing Home ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Young Onset ◽  
Psychotropic Drug Use ◽  
Nursing Home Patients ◽  
Young Onset Dementia

The effects of medication assessment on psychotropic drug use in the community-dwelling elderly

2010 ◽  
Vol 23 (3) ◽  
pp. 473-484 ◽  
Author(s):  
Maria Rikala ◽  
Maarit Jaana Korhonen ◽  
Raimo Sulkava ◽  
Sirpa Hartikainen
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Intervention Group ◽  
Community Dwelling ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Psychotropic Drug Use ◽  
And Control

ABSTRACTBackground:The study evaluated the effects of an annual medication assessment conducted as part of a Comprehensive Geriatric Assessment (CGA) on the prevalence of psychotropic drug use in community-dwelling elderly people.Methods:Randomly selected persons (n = 1000) aged ≥75 years living in the city of Kuopio, Finland were randomized to intervention and control groups. The intervention group underwent an annual (2004–2006) medication assessment as part of a CGA by physicians. Data on drug use were gathered by interviews at baseline (2004) and in three following years (2005–2007). Generalized estimating equations (GEE) were applied to explore whether the prevalence of psychotropic drug use differed between the community-dwelling participants of the intervention (n = 361) and control groups (n = 339) over time.Results:At baseline, nearly 40% of the participants used psychotropic drugs in each group. In the intervention group, the study physicians implemented 126 psychotropic drug-related changes, 39% of which were persistent after one year. The prevalence of use of psychotropic drugs, antipsychotics and anxiolytic/hypnotics did not differ between the groups over time. The prevalence of antidepressant use remained constant in the intervention group, but increased in the control group (p-value for interaction = 0.039). The prevalence of concomitant use of psychotropic drugs decreased non-significantly in the intervention group, but increased in the control group (p-value for interaction = 0.009).Conclusions:Conducting an annual medication assessment outside the usual primary health care system does not appear to reduce the prevalence of psychotropic drug use in community-dwelling elderly people. However, it may prevent concomitant use of psychotropic drugs.

scholarly journals Behavior and Evolution of Young ONset Dementia part 2 (BEYOND-II) study: an intervention study aimed at improvement in the management of neuropsychiatric symptoms in institutionalized people with young onset dementia

2017 ◽  
Vol 30 (3) ◽  
pp. 437-446 ◽  
Author(s):  
J. C. L. van Duinen-van den IJssel ◽  
B. Appelhof ◽  
S. A. Zwijsen ◽  
M. Smalbrugge ◽  
F. R. J. Verhey ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychotropic Drug ◽  
Unmet Needs ◽  
Neuropsychiatric Symptoms ◽  
Care Program ◽  
Community Dwelling ◽  
Care Needs ◽  
Young Onset ◽  
Young Onset Dementia

ABSTRACTBackground:Both neuropsychiatric symptoms (NPS) and psychotropic drug use (PDU) are common in institutionalized People with Young Onset Dementia (PwYOD) and can produce negative outcomes such as reduced quality of life and high workload. In community-dwelling PwYOD, NPS are found to be associated with unmet care needs. This emphasizes the importance of a care program for the management of NPS in institutionalized PwYOD that also addresses unmet care needs and PDU. The objectives of the Behavior and Evolution of Young ONset Dementia part 2 (BEYOND-II) study are to develop a care program for the management of NPS in institutionalized PwYOD and to evaluate its effectiveness.Methods:The care program consists of an educational program combined with an intervention to manage NPS with the following five steps: the evaluation of psychotropic drug prescription, detection, analysis (including the detection of unmet needs), treatment and the evaluation of NPS. A stepped wedge design will be used to evaluate its effectiveness. The primary outcomes are agitation and aggression and other NPS. The secondary outcomes are PDU, quality of life, the workload of nursing staff and job satisfaction. Additionally, a process analysis and a cost-consequence analysis will be conducted.Conclusions:The study protocol of the Beyond-II study describes the development, implementation and evaluation of a care program for the management of NPS in institutionalized PwYOD. This care program provides a structured method for the management of NPS, in which unmet needs and PDU are also addressed.

scholarly journals Change in psychotropic drug use among community-dwelling people aged 75 years and older in Finland: repeated cross-sectional population studies

2011 ◽  
Vol 23 (8) ◽  
pp. 1278-1284 ◽  
Author(s):  
Franciska Desplenter ◽  
Charlotte Caenen ◽  
Jolein Meelberghs ◽  
Sirpa Hartikainen ◽  
Raimo Sulkava ◽  
...  
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Adverse Drug Events ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Psychotropic Drug Use ◽  
Random Samples ◽  
Antidepressant Use ◽  
Status Differences ◽  
Compare And Contrast

ABSTRACTBackground: Older people are at high risk of experiencing psychotropic-related adverse drug events. The objective of this study was to compare and contrast the use of psychotropic drugs among community-dwelling people aged ≥75 years in 1998 and 2004.Methods: Comparable random samples of people aged ≥75 years were extracted from the population register in Kuopio, Finland, in 1998 (n = 700) and 2003 (n = 1000). In 1998 and 2004, 523 and 700 community-dwelling people respectively participated in nurse interviews, during which demographic, diagnostic and drug use data were elicited. Logistic regression was used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of psychotropic drug use in 2004 compared to 1998.Results: The unadjusted prevalence of total psychotropic (37.3% and 38.4%, OR 1.05; 95% CI 0.83–1.33), anxiolytic, hypnotic and sedative (29.6% and 31.3%, OR 1.08, 95% CI 0.85–1.38), and antidepressant (10.7% and 11.9%, OR 1.12, 95% CI 0.78–1.61) use were similar in 1998 and 2004. There was a decrease in the unadjusted prevalence of antipsychotic use (9.2% and 5.7%, OR 0.60; 95% CI 0.39–0.93). After adjusting for socioeconomic and health status differences, there was an increase in the prevalence of total psychotropic (adjusted OR 1.31, 95% CI 1.01–1.70) and antidepressant (OR 1.59, 95% CI 1.06–2.40) use.Conclusion: The unadjusted prevalence of psychotropic drug use remained stable between 1998 and 2004. However, in adjusted analyses there was a small increase in the prevalence of any psychotropic drug use and antidepressant use specifically.

Use of Psychotropic Drugs in Gynecological, Surgical, and Medical Wards of General Hospitals

1998 ◽  
Vol 28 (3) ◽  
pp. 303-314 ◽  
Author(s):  
J. Wancata ◽  
N. Benda ◽  
U. Meise ◽  
C. Müller
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychiatric Illness ◽  
Psychiatric Morbidity ◽  
Older Age ◽  
Sociodemographic Characteristics ◽  
General Hospitals ◽  
Psychotropic Drug Use ◽  
Medical Wards

Objective: The purpose of the present study was to investigate the prevalence of psychotropic drug use and the predictors of use during hospitalization. Method: We investigated 728 patients admitted to medical, gynecological, and surgical wards of two non-university general hospitals in Austria for psychotropic drug use, psychiatric morbidity, and sociodemographic characteristics. Results: The use of psychotropics was highest in medical wards (67.6%), followed by surgical (59.3%), and gynecological wards (37.8%). Older age, psychiatric caseness, consultation by psychiatrists and use of psychotropics before admission were predictors for psychotropic drug use. Psychotropics were given for a longer duration to psychiatric cases than to non-cases. Anxiolytics were prescribed most often (39.6%), followed by hypnotics (16.9%), neuroleptics (10.7%), and antidepressants (7.0%). Conclusions: The fact that psychiatric illness is a significant predictor of psychotropic drug use suggests that these drugs were prescribed aptly. The longer duration of use among psychiatric cases supports the idea of appropriate prescriptions.

Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals

2020 ◽  
Vol 53 (03) ◽  
pp. 133-137
Author(s):  
Julia C. Stingl ◽  
Katja S. Just ◽  
Marlen Schurig ◽  
Miriam Böhme ◽  
Michael Steffens ◽  
...  
Keyword(s):  
Older Adults ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Drug Users ◽  
Prospective Observational Study ◽  
Drug Reactions ◽  
Specific Patient ◽  
Psychotropic Drug Use

Abstract Introduction The prevalence of psychotropic drug use in our society is increasing especially in older adults, thereby provoking severe adverse drug reactions (ADR). To identify specific patient risk profiles associated with psychotropic drug use in the situation of polymedication. Methods Cases of ADRs in general emergency departments (ED) collected within the multi-center prospective observational study (ADRED) were analyzed (n=2215). We compared cases with use of psychotropic drugs and without concerning their clinical presentation at the ED. Results A third of patients (n=731, 33%) presenting to the ED with an ADR took at least 1 psychotropic drug. Patients with psychotropic drug use tended to be older, more often female, and took a higher number of drugs (all p<0.001). The frequency of falls was almost 3 times higher than compared to the non-psychotropic drug group (10.5 vs. 3.9%, p<0.001), and similar syncope was also more often seen in the psychotropic drug users (8.8 vs. 5.5%, p=0.004). The use of psychotropic drugs increased the risk for falls by a factor of 2.82 (OR, 95% CI (1.90–4.18)), when adjusting for gender, age, numbers of pre-existing diseases, and drugs, respectively. Discussion The association of psychotropic drug use with fall and syncope in combination with polymedication and older age leads to the suspicion that psychotropic drugs might be potentially harmful in specific risk populations such as older adults. It may lead us to thoroughly weigh the benefit against risk in a patient-oriented way, leading to an integrative personalized therapy approach.

Psychotropic drug use in relation to mental disorders and institutionalization among 95-year-olds: a population-based study

2011 ◽  
Vol 23 (8) ◽  
pp. 1270-1277 ◽  
Author(s):  
Eva Lesén ◽  
Anders Carlsten ◽  
Ingmar Skoog ◽  
Margda Waern ◽  
Max Petzold ◽  
...  
Keyword(s):  
Drug Use ◽  
Mental Disorders ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychotic Disorders ◽  
Rating Scale ◽  
The Elderly ◽  
Population Based ◽  
Prescribing Patterns ◽  
Psychotropic Drug Use

ABSTRACTBackground: The prevalence of psychotropic drug use is high among the elderly, but research on how psychotropic drugs are used among individuals aged 90 years and older is limited. An increased knowledge on this topic may contribute to improved prescribing patterns in this vulnerable population. The aim of this study was to assess the use of psychotropic drugs in relation to mental disorders and institutionalization among 95-year-olds and to identify use of potentially inappropriate psychotropic drugs.Methods: All 95-year-olds born in 1901–1903 living in nursing homes or community settings in Gothenburg, Sweden were invited to participate. The response rate was 65% and 338 95-year-olds were examined (263 women, 75 men). Psychotropic drug use in relation to mental disorders and institutionalization was assessed. Information on drug use was collected primarily from multi-dose drug dispensing lists. Participants were examined by trained psychiatrists using the Comprehensive Psychopathological Rating Scale and a battery of cognitive tests. Dementia, depression, anxiety and psychotic disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (DSM-III-R).Results: Sixty percent of the 95-year-old participants used psychotropic drugs; hypnotics were most common (44%). Potentially inappropriate psychotropics were observed in one third (33%). Antidepressants were used by 7% of the participants without dementia who fulfilled criteria for a depressive disorder, while 56% used hypnotics and 30% used anxiolytics.Conclusions: The high prevalence of psychotropic drug use and the nonspecific nature of these treatments among 95-year-olds indicate a need for improvement in prescribing patterns.

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