Treatment of chronic resistant paediatric idiopathic pericardial effusion with intrapericardial injection of corticosteroids 4-year-old girl with rapid full resolution after intrapericardial injection of corticosteroids

2021 ◽  
pp. 1-3
Author(s):  
Takhfif Othman ◽  
Osama Eldadah
Keyword(s):  
Pericardial Effusion ◽  
Conventional Therapy ◽  
Complete Resolution ◽  
Conventional Treatment ◽  
Management Options ◽  
Conventional Management ◽  
Full Resolution ◽  
Paediatric Case ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Non-steroidal anti-inflammatory drugs are the conventional treatment for pericarditis. However, some patients will still suffer from persistence pericardial effusion despite exhausting all conventional management options. A 4-year-old girl with idiopathic pericardial effusion who did not respond to 2 months of conventional therapy had complete resolution of effusion within 5 days, with no recurrence after administration of intrapericardial steroids. As far as we know, this is the first published paediatric case who has shown a similar outcome to that seen in adult studies.

scholarly journals ‘Dry’ Pericarditis with Rapid Progression to Tamponade as a Feature of COVID-19

2021 ◽  
Author(s):  
Ashwin Reddy ◽  
Sarah Nethercott ◽  
Rudolph Duehmke ◽  
Sunil Nair ◽  
Omar Abdul-Samad
Keyword(s):  
Pericardial Effusion ◽  
Severe Acute Respiratory Syndrome ◽  
Stable Condition ◽  
Full Recovery ◽  
Rapid Progression ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Pericardial inflammation is a recognised feature of coronavirus disease (COVID-19). The authors herein present the case of a female with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection who developed a large and life-threatening pericardial effusion over a few days following the onset of pericarditis, despite prompt commencement of treatment. This was successfully drained, and she was discharged in stable condition on oral nonsteroidal anti-inflammatory drugs and colchicine.At 6-week follow-up she had made a full recovery, and repeat echocardiography demonstrated no recurrence of effusion or evidence of constrictive physiology.

scholarly journals Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication

2019 ◽  
Vol 12 (11) ◽  
pp. e231619 ◽  
Author(s):  
Florian Desgranges ◽  
Nathalie Tebib ◽  
Olivier Lamy ◽  
Antonios Kritikos
Keyword(s):  
Complete Resolution ◽  
Viral Infections ◽  
Empirical Therapy ◽  
Neurological Sequela ◽  
Review Of The Literature ◽  
Acute Meningitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Tension Type Headaches

A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory drug (NSAID) induced meningitis due to the temporal relationship between drug administration and symptom onset. Two days after NSAID suppression, the evolution was progressively favourable with complete resolution of fever and symptoms. On follow-up, symptoms did not recur and there was no neurological sequela. This article summarises the clinical picture and the complementary exams that led to the difficult-to-make diagnosis of NSAID-induced acute meningitis, in parallel with a brief review of the literature.

scholarly journals Simultaneous Subconjunctival Triamcinolone and Bevacizumab Injections for Management of Blepharokeratoconjunctivitis in Children

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Chu Luan Nguyen ◽  
Tony S. Chen ◽  
Khoi Tran ◽  
James E. H. Smith ◽  
Noni Lewis
Keyword(s):  
Conventional Treatment ◽  
Case Series ◽  
Corneal Neovascularization ◽  
Conjunctival Injection ◽  
Management Options ◽  
Conventional Management ◽  
Palpebral Conjunctiva ◽  
Meibomian Glands ◽  
Corneal Infiltrates ◽  
Red Eyes

Purpose. To report the efficacy of subconjunctival triamcinolone (Kenalog A-40, Alcon) and bevacizumab (Avastin, Genentech) injections in fraternal twins with blepharokeratoconjunctivitis (BKC) causing progressive, bilateral corneal neovascularization and scarring. Methods. In this retrospective observational case series, two three-year-old male twins with BKC had presented with bilateral red eyes, photophobia, and frequent blinking. Examination of each child showed bilateral deep stromal and superficial corneal neovascularization, corneal infiltrates, multiple follicles on the palpebral conjunctiva bilaterally with blepharitis, and thick turbid sebum expressed from the Meibomian glands. Their disease progressed despite conventional treatment. Both twins were managed with subconjunctival triamcinolone injection and subconjunctival bevacizumab injection of each eye. Results. The treatment resulted in improvement of symptoms, and examination over an 8-10-month period postinjections showed fading stromal corneal infiltrates, partially regressed corneal neovascularization, and reduced conjunctival injection without complications. Conclusion. This case series highlights the potential vision threatening complications of BKC. In addition to conventional management options, this report is the first published use of subconjunctival triamcinolone and bevacizumab injections for BKC in children in an attempt to minimize and improve corneal neovascularization and scarring and subsequently to retain useful vision.

scholarly journals Effect of Anti-Inflammatory Drugs on Clinical Outcomes in Patients With Malignant Pericardial Effusion

2020 ◽  
Vol 76 (13) ◽  
pp. 1551-1561 ◽  
Author(s):  
So Ree Kim ◽  
Eun Kyoung Kim ◽  
Jinhyun Cho ◽  
Sung-A Chang ◽  
Sung-Ji Park ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Clinical Outcomes ◽  
Malignant Pericardial Effusion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature

2003 ◽  
Vol 17 (8) ◽  
pp. 497-500 ◽  
Author(s):  
Robert M Penner ◽  
C Noel Williams
Keyword(s):  
Abdominal Pain ◽  
Complete Resolution ◽  
Nsaid Therapy ◽  
University Hospital ◽  
Review Of The Literature ◽  
Drug Induced ◽  
First Case ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Colonic Strictures

A 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm disease. Discontinuation of NSAID therapy did not result in endoscopic change, but a 20-week course of prednisone was followed by complete resolution. This is the first case describing prednisone monotherapy for such strictures, and only the second in which endoscopic resolution has been documented. With further supporting experience, prednisone may be considered in addition to NSAID discontinuation for patients with this rare but serious complication.

scholarly journals Mesotherapy versus Systemic Therapy in the Treatment of Acute Low Back Pain: A Randomized Trial

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Cosimo Costantino ◽  
Emilio Marangio ◽  
Gabriella Coruzzi
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Conventional Therapy ◽  
Functional Disability ◽  
Therapy Group ◽  
Pharmacological Therapy ◽  
Low Back ◽  
Acute Low Back Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Pharmacological therapy of back pain with analgesics and anti-inflammatory drugs is frequently associated with adverse effects, particularly in the elderly. Aim of this study was to compare mesotherapic versus conventional systemic administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids in patients with acute low back pain. Eighty-four patients were randomized to receive anti-inflammatory therapy according to the following protocols: (a) mesotherapy group received the 1st and 4th day 2% lidocaine (1 mL) + ketoprofen 160 mg (1 mL) + methylprednisolone 40 mg (1 mL), then on 7th, 10th, and 13th day, 2% lidocaine (1 mL) + ketoprofen 160 mg (1 mL) + methylprednisolone 20 mg (1 mL) (b) conventional therapy group received ketoprofen 80 mg×2/die and esomeprazole 20 mg/die orally for 12 days, methylprednisolone 40 mg/die intramuscularly for 4 days, followed by methylprednisolone 20 mg/die for 3 days, and thereafter, methylprednisolone 20 mg/die at alternate days. Pain intensity and functional disability were assessed at baseline (T0), at the end of treatment (T1), and 6 months thereafter (T2) by using visual analogic scale (VAS) and Roland-Morris disability questionnaire (RMDQ). In both groups, VAS and RMDQ values were significantly reduced at the end of drug treatment and after 6 months, in comparison with baseline. No significant differences were found between the two groups. This suggests that mesotherapy may be a valid alternative to conventional therapy in the treatment of acute low back pain with corticosteroids and NSAIDs.

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