scholarly journals Role of Disgust Proneness in Parkinson’s Disease: A Voxel-Based Morphometry Study

2015 ◽  
Vol 21 (4) ◽  
pp. 314-317 ◽  
Author(s):  
Rottraut Ille ◽  
Albert Wabnegger ◽  
Petra Schwingenschuh ◽  
Petra Katschnig-Winter ◽  
Mariella Kögl-Wallner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter Volume ◽  
Piriform Cortex ◽  
Normal Male ◽  
Clinical Group ◽  
Voxel Based Morphometry ◽  
Olfactory Stimuli ◽  
Morphometry Analysis ◽  
Disgust Proneness

AbstractThe knowledge about personality traits in Parkinson’s disease (PD) is still limited. In particular, disgust proneness has not been investigated as well as its neuronal correlates. Although several morphometric studies demonstrated that PD is associated with gray matter volume (GMV) reduction in olfactory and gustatory regions involved in disgust processing, a possible correlation with disgust proneness has not been investigated. We conducted a voxel-based morphometry analysis to compare GMV between 16 cognitively normal male PD patients with mild to moderate symptoms and 24 matched control subjects. All participants had answered questionnaires for the assessment of disgust proneness, trait anger and trait anxiety. We correlated questionnaire scores with GMV in both groups. The clinical group reported selectively reduced disgust proneness toward olfactory stimuli associated with spoilage. Moreover, they showed GMV reduction in the central olfactory system [orbitofrontal cortex (OFC) and piriform cortex]. Disgust items referring to olfactory processing were positively correlated with OFC volume in PD patients. Our data suggest an association between PD-associated neurodegeneration and olfactory related facets of the personality trait disgust proneness. (JINS, 2015, 21, 314–317)

scholarly journals Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study

BMC Neurology ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Sieh-Yang Lee ◽  
Meng-Hsiang Chen ◽  
Pi-Ling Chiang ◽  
Hsiu-Ling Chen ◽  
Kun-Hsien Chou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Voxel Based Morphometry ◽  
Respiratory Dysfunction ◽  
Matter Volume

scholarly journals Assessment of cortical degeneration in patients with Parkinson's disease by voxel-based morphometry, cortical folding, and cortical thickness

2011 ◽  
Vol 33 (11) ◽  
pp. 2521-2534 ◽  
Author(s):  
Joana Braga Pereira ◽  
Naroa Ibarretxe-Bilbao ◽  
Maria-Jose Marti ◽  
Yaroslau Compta ◽  
Carme Junqué ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cortical Thickness ◽  
Cortical Folding ◽  
Voxel Based Morphometry

scholarly journals Morphometric changes of gray matter in Parkinson's disease with depression: A voxel-based morphometry study

2008 ◽  
Vol 23 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Adam Feldmann ◽  
Zsolt Illes ◽  
Peter Kosztolanyi ◽  
Eniko Illes ◽  
Andrea Mike ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Voxel Based Morphometry

Depressive symptoms in Parkinson’s disease are related to decreased left hippocampal volume: correlation with the 15-item shortened version of the Geriatric Depression Scale

2017 ◽  
Vol 59 (3) ◽  
pp. 341-345 ◽  
Author(s):  
Masami Goto ◽  
Koji Kamagata ◽  
Taku Hatano ◽  
Nobutaka Hattori ◽  
Osamu Abe ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Hippocampal Volume ◽  
Geriatric Depression ◽  
Matter Volume ◽  
The Relationship

Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson’s disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e.g. GDS-15, Mini-Mental State Examination, PD duration, age, sex). Statistical Parametric Mapping 8 software was used for image gray matter segmentation and for a correlation analysis between gray matter volume and GDS-15 score. Results The results showed a significant negative correlation between GDS-15 score and left hippocampal volume, and between GDS-15 score and right parahippocampal gyrus volume. No significant positive correlations were found in the whole brain. Conclusion The current results provide new evidence regarding the relationship between depression in PD and hippocampal volume.

scholarly journals DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson’s Disease: Voxel-Based Morphometry

2020 ◽  
Author(s):  
Kenji Ohira ◽  
Hajime Yokota ◽  
Shigeki Hirano ◽  
Motoi Nishimura ◽  
Hiroki Mukai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Volume ◽  
Clinical Performance ◽  
Morphological Changes ◽  
Compensatory Mechanism ◽  
Voxel Based Morphometry ◽  
Cortical Function ◽  
Increased Risk ◽  
The Relationship

Abstract Taq1A polymorphism is a DRD2 gene variant located in an exon of the ANKK1 gene and has an important role in the brain’s dopaminergic functions. Some studies have indicated that A1 carriers have an increased risk of developing Parkinson’s disease (PD) and show poorer clinical performance than A2 homo carriers. Previous studies have suggested that A1 carriers had fewer dopamine D2 receptors in the caudate and increased cortical activity as a compensatory mechanism. However, there is little information about morphological changes associated with this polymorphism in patients with PD. The study aim was to investigate the relationship between brain volume and Taq1A polymorphism in PD using voxel-based morphometry (VBM). Based on Taq1A polymorphism, 103 patients with PD were divided into two groups: A1 carriers (A1/A1, A1/A2) and A2 homo carriers (A2/A2). The volume of the left prefrontal cortex (PFC) was significantly decreased in A2 homo carriers compared to A1 carriers. This finding supports the association between Taq1A polymorphism and brain volume in PD and may explain the compensation of cortical function in A1 carriers with PD.

scholarly journals EEG features in patients with Parkinson's disease during directional perception of olfactory stimuli

2021 ◽  
Vol 15 (4) ◽  
pp. 27-35
Author(s):  
Sergey P. Kozhevnikov ◽  
Irina L. Ivanova ◽  
Natalia V. Komissarova ◽  
Anastasia V. Shubina ◽  
Matvey A. Vlasov
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Right Hemisphere ◽  
Olfactory Dysfunction ◽  
Olfactory Stimulation ◽  
Control Group ◽  
Olfactory Perception ◽  
Study Results ◽  
Olfactory Stimuli ◽  
The Right

Introduction. Olfactory dysfunction is considered to be an early and relatively important marker of Parkinson's disease (PD). Olfactory studies using objective neurophysiological methods may become one of the diagnostic tests to identify individuals with a high risk of developing PD. The aim of the study was to assess the spectral and topographic characteristics of bioelectrical brain activity in patients with PD during directional perception of olfactory stimuli. Materials and methods. This study included 30 patients with PD (mean age was 66.5 6.5 years). The control group consisted of 20 people without PD (mean age was 65.3 8.5 years). Lavender oil, clove oil, camphor oil and -mercaptoethanol solution (an aversive stimulus) were used for olfactory stimulation, while distilled water was used as a control test. The test subject sat with their eyes closed and inhaled the presented smell for 30 seconds, while an EEG recording was made during this time. Study results. Olfactory stimulation in patients with PD showed increased synchronicity of the 3 rhythm in the right hemisphere, as well as the rhythm in the parieto-occipital regions of both hemispheres. These changes indicate significant activation of internal (endogenous) attention, increased overall, non-specific readiness potential, as well as the involvement of the limbic-reticular complex in olfactory perception. Olfactory perception in the control group was accompanied by reduction in the 1 rhythm amplitude in the parieto-occipital regions bilaterally, which may indicate moderate activation of external (exogenous) attention and the posterior attention system responsible for simple perception processes. Conclusion. Increased 3 rhythm amplitude in the right hemisphere and increased rhythm amplitude, observed during directional olfactory perception, may indicate olfactory dysfunction and should be viewed as an additional indicator when establishing a diagnosis of Parkinsons disease.

scholarly journals Reduced Gray Matter Volume and Risk of Falls in Parkinson’s Disease with Dementia Patients: A Voxel-Based Morphometry Study

2020 ◽  
Vol 17 (15) ◽  
pp. 5374
Author(s):  
Kai-Lun Cheng ◽  
Li-Han Lin ◽  
Po-Cheng Chen ◽  
Pi-Ling Chiang ◽  
Yueh-Sheng Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Gray Matter ◽  
Inferior Frontal Gyrus ◽  
Gray Matter Volume ◽  
Voxel Based Morphometry ◽  
Matter Volume ◽  
Risk Of Falls

Purpose: Risk of falls is a common sequela affecting patients with Parkinson’s disease (PD). Although motor impairment and dementia are correlated with falls, associations of brain structure and cognition deficits with falls remain unclear. Material and Methods: Thirty-five PD patients with dementia (PDD), and 37 age- and sex-matched healthy subjects were recruited for this study. All participants received structural magnetic resonance imaging (MRI) scans, and disease severity and cognitive evaluations. Additionally, patient fall history was recorded. Regional structural differences between PDD with and without fall groups were performed using voxel-based morphometry processing. Stepwise logistic regression analysis was used to predict the fall risk in PDD patients. Results: The results revealed that 48% of PDD patients experienced falls. Significantly lower gray matter volume (GMV) in the left calcarine and right inferior frontal gyrus in PDD patients with fall compared to PDD patients without fall were noted. The PDD patients with fall exhibited worse UPDRS-II scores compared to PDD patients without fall and were negatively correlated with lower GMV in the left calcarine (p/r = 0.004/−0.492). Furthermore, lower GMV in the left calcarine and right inferior frontal gyrus correlated with poor attention and executive functional test scores. Multiple logistic regression analysis showed that the left calcarine was the only variable (p = 0.004, 95% CI = 0.00–0.00) negatively associated with the fall event. Conclusions: PDD patients exhibiting impaired motor function, lower GMV in the left calcarine and right inferior frontal gyrus, and notable cognitive deficits may have increased risk of falls.

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