Design and Validation of a Low-Cost Microscope for Diagnostics in the Developing World

2009 ◽  
Vol 17 (6) ◽  
pp. 16-19 ◽  
Author(s):  
B. Cline ◽  
R. Luo ◽  
K. Kuhlmann
Keyword(s):  
High Resolution ◽  
Infectious Diseases ◽  
Developing World ◽  
Low Cost ◽  
High Resolution Imaging ◽  
Microscope Examination ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Resolution Imaging

Many infectious diseases prevalent in the developing world, including malaria and tuberculosis, are difficult to diagnose on the basis of symptoms alone but can be accurately detected using microscope examination. Currently the expense, size, and fragility of optical microscopes impede their widespread use in resource-limited settings. Addressing these obstacles facing microscopy in the developing world is a pressing need; over 800,000 people, primarily children in Africa, die annually of malaria, and more than 1,500,000 people die annually of tuberculosis [1][2]. The aim of this study is to design and validate a microscope for use in the developing world that combines high-resolution imaging, extreme affordability, and long-term durability.

LONG-TERM SAFETY, HIGH-RESOLUTION IMAGING, AND TISSUE TEMPERATURE MODELING OF SUBVISIBLE DIODE MICROPULSE PHOTOCOAGULATION FOR RETINOVASCULAR MACULAR EDEMA

Retina ◽  
2012 ◽  
Vol 32 (2) ◽  
pp. 375-386 ◽  
Author(s):  
Jeffrey K. Luttrull ◽  
Christopher Sramek ◽  
Daniel Palanker ◽  
Charles J. Spink ◽  
David C. Musch
Keyword(s):  
High Resolution ◽  
Macular Edema ◽  
Tissue Temperature ◽  
High Resolution Imaging ◽  
Temperature Modeling ◽  
Resolution Imaging

Long-Term, High-Resolution Imaging in the Neocortex In Vivo

2008 ◽  
Vol 2008 (2) ◽  
pp. pdb.prot4902-pdb.prot4902 ◽  
Author(s):  
B. E. Chen ◽  
J. T. Trachtenberg ◽  
A. J.G.D. Holtmaat ◽  
K. Svoboda
Keyword(s):  
High Resolution ◽  
High Resolution Imaging ◽  
Resolution Imaging

scholarly journals A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D

2018 ◽  
Vol 15 (3) ◽  
pp. 035001
Author(s):  
Yuan Ren ◽  
Michael J Mlodzianoski ◽  
Aih Cheun Lee ◽  
Fang Huang ◽  
Daniel M Suter
Keyword(s):  
High Resolution ◽  
Neurite Outgrowth ◽  
Low Cost ◽  
High Resolution Imaging ◽  
Resolution Imaging

scholarly journals High-resolution imaging in Barrett's esophagus: a novel, low-cost endoscopic microscope

2008 ◽  
Vol 68 (4) ◽  
pp. 737-744 ◽  
Author(s):  
Timothy J. Muldoon ◽  
Sharmila Anandasabapathy ◽  
Dipen Maru ◽  
Rebecca Richards-Kortum
Keyword(s):  
High Resolution ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Cost ◽  
High Resolution Imaging ◽  
Resolution Imaging

scholarly journals Ultra-High Resolution Imaging Method for Distributed Small Satellite Spotlight MIMO-SAR Based on Sub-Aperture Image Fusion

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1609
Author(s):  
Fang Zhou ◽  
Jun Yang ◽  
Lu Jia ◽  
Xingming Yang ◽  
Mengdao Xing
Keyword(s):  
High Resolution ◽  
Low Cost ◽  
Multiple Input Multiple Output ◽  
Imaging Method ◽  
High Resolution Imaging ◽  
Small Satellite ◽  
Fusion Algorithm ◽  
Large Bandwidth ◽  
Input Multiple Output ◽  
Resolution Imaging

Small satellite synthetic aperture radar (SAR) has become a new development direction of spaceborne SAR due to its advantages of flexible launch, short development cycle, and low cost. However, there are fewer researches on distributed small satellite multiple input multiple output (MIMO) SAR. This paper proposes an ultra-high resolution imaging method for the distributed small satellite spotlight MIMO-SAR, which applies the sub-aperture division technique and the sub-aperture image coherent fusion algorithm to MIMO-SAR. After deblurring the sub-aperture signal, the large bandwidth signal is obtained by using an improved time domain bandwidth synthesis (TBS) method, and then the ultra-high resolution image is obtained by using a sub-aperture image coherent fusion algorithm. Simulation results validate the feasibility and effectiveness of the proposed approach.

scholarly journals 3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Mariana Oksdath Mansilla ◽  
Camilo Salazar-Hernandez ◽  
Sally L. Perrin ◽  
Kaitlin G. Scheer ◽  
Gökhan Cildir ◽  
...  
Keyword(s):  
High Resolution ◽  
Cell Tracking ◽  
Culture Conditions ◽  
Significant Advance ◽  
High Resolution Imaging ◽  
Whole Brain ◽  
3D Printed ◽  
Resolution Imaging ◽  
Brain Organoid

Abstract Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be constantly agitated to allow proper oxygenation. The culture conditions are, therefore, not suitable for whole-brain organoid live imaging, required to study developmental processes and disease progression within physiologically relevant time frames (i.e. days, weeks, months). Results Here we designed 3D-printed microplate inserts adaptable to standard 24 multi-well plates, which allow the growth of multiple organoids in pre-defined and fixed XYZ coordinates. This innovation facilitates high-resolution imaging of whole-cerebral organoids, allowing precise assessment of organoid growth and morphology, as well as cell tracking within the organoids, over long periods. We applied this technology to track neocortex development through neuronal progenitors in brain organoids, as well as the movement of patient-derived glioblastoma stem cells within healthy brain organoids. Conclusions This new bioengineering platform constitutes a significant advance that permits long term detailed analysis of whole-brain organoids using multimodal inverted fluorescence microscopy.

Microfluidic Hydrogel Hanging-Drop Network for Long-Term Culturing of 3D Microtissues and Simultaneous High-Resolution Imaging

2018 ◽  
Vol 2 (7) ◽  
pp. 1800054 ◽  
Author(s):  
Elise A. Aeby ◽  
Patrick M. Misun ◽  
Andreas Hierlemann ◽  
Olivier Frey
Keyword(s):  
High Resolution ◽  
High Resolution Imaging ◽  
Hanging Drop ◽  
Resolution Imaging

scholarly journals Microfluidic Cell Culturing Platform Combining Long-term, High-resolution Imaging with Impedance Spectroscopy

2015 ◽  
Vol 120 ◽  
pp. 154-157 ◽  
Author(s):  
Ketki Chawla ◽  
Sebastian C. Bürgel ◽  
Gregor W. Schmidt ◽  
Fabian Rudolf ◽  
Olivier Frey ◽  
...  
Keyword(s):  
High Resolution ◽  
Impedance Spectroscopy ◽  
High Resolution Imaging ◽  
Cell Culturing ◽  
Resolution Imaging
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