The Swedish Twin Registry: Content and Management as a Research Infrastructure

AbstractThe Swedish Twin Registry functions as research infrastructure containing information on 216,258 twins born between 1886 and 2015, of whom 86,199 pairs have zygosity determined by DNA, an intrapair similarity algorithm, or being of opposite sex. In essence, practically all twins alive and currently 9 years or older have been invited for participation and donation of DNA on which genomewide single nucleotide polymorphisms array genotyping has been performed. Content, management and alternatives for future improvements are discussed.

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The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments

Twin Research and Human Genetics ◽

10.1017/thg.2012.104 ◽

2012 ◽

Vol 16 (1) ◽

pp. 317-329 ◽

Cited By ~ 186

Author(s):

Patrik K. E. Magnusson ◽

Catarina Almqvist ◽

Iffat Rahman ◽

Andrea Ganna ◽

Alexander Viktorin ◽

...

Keyword(s):

Same Sex ◽

Vitro Fertilization ◽

The Past ◽

Twin Registry ◽

Molecular Studies ◽

Similarity Algorithm ◽

Recent Developments ◽

Opposite Sex ◽

Swedish Twin Registry

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.

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Development of a simple method for the determination of single nucleotide polymorphisms

Cell Biology International ◽

10.1042/cbi034s075c ◽

2010 ◽

Vol 34 (8) ◽

pp. S75-S75

Author(s):

Weifeng Zhu ◽

Zhuoqi Liu ◽

Daya Luo ◽

Xinyao Wu ◽

Fusheng Wan

Keyword(s):

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Simple Method ◽

Single Nucleotide

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Single nucleotide polymorphisms in intron 5 of the feline myosin regulatory light chain gene detected by SSCP analysis

Animal Genetics ◽

10.1046/j.1365-2052.2000.00620.x ◽

2000 ◽

Vol 31 (4) ◽

pp. 281-282

Author(s):

A L Magnon ◽

K M Meurs ◽

M D Kittleson ◽

W A Ware

Keyword(s):

Single Nucleotide Polymorphisms ◽

Light Chain ◽

Regulatory Light Chain ◽

Sscp Analysis ◽

Chain Gene ◽

Myosin Regulatory Light Chain ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Light Chain Gene

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Single nucleotide polymorphisms of the factor IX gene for linkage analysis in the southern Chinese population

British Journal of Haematology ◽

10.1046/j.1365-2141.2000.02384.x ◽

2000 ◽

Vol 111 (2) ◽

pp. 540-543 ◽

Cited By ~ 2

Author(s):

Vivian Chan ◽

Irene Yam ◽

B. Yip ◽

P. Au ◽

M. K. Shing ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Linkage Analysis ◽

Chinese Population ◽

Factor Ix ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Southern Chinese

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W14.373 A single nucleotide polymorphisms of the apolipoprotein A-V gene (SNP3, T-1131C) modulates postprandial lipoprotein metabolism

Atherosclerosis ◽

10.1016/s0021-9150(04)90372-3 ◽

2004 ◽

Vol 5 (1) ◽

pp. 86

Author(s):

C MARIN

Keyword(s):

Single Nucleotide Polymorphisms ◽

Lipoprotein Metabolism ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Apolipoprotein A ◽

V Gene ◽

Postprandial Lipoprotein

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Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

Journal of Individual Differences ◽

10.1027/1614-0001.28.3.161 ◽

2007 ◽

Vol 28 (3) ◽

pp. 161-164 ◽

Cited By ~ 1

Author(s):

Rosalind Arden ◽

Nicole Harlaar ◽

Robert Plomin

Keyword(s):

Sex Differences ◽

Single Nucleotide Polymorphisms ◽

Cognitive Ability ◽

Dna Markers ◽

Community Sample ◽

Nucleotide Polymorphisms ◽

General Cognitive Ability ◽

Single Nucleotide ◽

The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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