Mapping Isomeric Peptides Derived from Biopharmaceuticals Using High-Resolution Ion Mobility Mass Spectrometry

2021 ◽  
Author(s):  
Nick Tomczyk ◽  
Kevin Giles ◽  
Keith Richardson ◽  
Jakub Ujma ◽  
Martin Palmer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry

High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids

The Analyst ◽  
2015 ◽  
Vol 140 (20) ◽  
pp. 6904-6911 ◽  
Author(s):  
M. Groessl ◽  
S. Graf ◽  
R. Knochenmuss
Keyword(s):  
Mass Spectrometry ◽  
Double Bond ◽  
High Resolution ◽  
Ion Mobility ◽  
Biological Samples ◽  
Drift Tube ◽  
Acyl Chain ◽  
Ion Mobility Mass Spectrometry

Separation and identification of isomeric species is a major challenge in lipidomics. Herein, we demonstrate that lipid isomers that differ only in position of the acyl chain, position of the double bond or double bond geometry can be distinguished using drift-tube ion mobility-mass spectrometry, even in complex biological samples.

Sign in / Sign up

Export Citation Format

Share Document