Cancer Selective Turn-On Fluorescence Imaging Using a Biopolymeric Nanocarrier

2019 ◽  
Vol 20 (2) ◽  
pp. 1068-1076 ◽  
Author(s):  
Yoon Jeong ◽  
Garam Kim ◽  
Soohyun Jeong ◽  
Byungchul Lee ◽  
Sangeun Kim ◽  
...  
Keyword(s):  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.


2021 ◽  
Author(s):  
Yiran Huang ◽  
Liang Sun ◽  
Liviu M. Mirica

<div>Protein misfolding and metal dishomeostasis are two key</div><div>pathological factors of Alzheimer’s disease. Previous studies have showed that Cu‐mediated Aβ aggregation pathways lead to formation of neurotoxic Aβ oligomers. Herein, we reported a series of picolinic acid‐based Cu‐activatable sensors, which can be used for the fluorescence imaging of Cu‐rich Aβ aggregates.</div>


The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 2982-2987 ◽  
Author(s):  
Jia Li ◽  
Yuhui Wang ◽  
Shan Sun ◽  
A-Man Lv ◽  
Kai Jiang ◽  
...  

A self-quenched nanoprobe built on a disulfide bond-based crosslink of carbon-dots has been constructed for intracellular GSH sensing.


2019 ◽  
Vol 3 (10) ◽  
pp. 2143-2150 ◽  
Author(s):  
Jianhua Zou ◽  
Lei Xue ◽  
Nan Yang ◽  
Yanfang Ren ◽  
Zhe Fan ◽  
...  

Herein, GSH responsive pyrrolopyrrolidone derivatives with enhanced photodynamic/photothermal therapeutic efficacy were designed, which can be used as colorimetric probes.


2015 ◽  
Vol 7 (24) ◽  
pp. 10371-10375 ◽  
Author(s):  
Lun Song ◽  
Qian Sun ◽  
Nan Wang ◽  
Zhaoyang Chen ◽  
Weibing Zhang ◽  
...  

A turn-on fluorescent probe was designed and synthesized for discriminating between Cys and GSH from different spectral channels. The probe has potential in fluorescence imaging of cellular Cys.


2015 ◽  
Vol 13 (17) ◽  
pp. 5006-5011 ◽  
Author(s):  
James N. Wilson ◽  
Wenjun Liu ◽  
Adrienne S. Brown ◽  
Ralf Landgraf

The photophysical properties, fluorescence imaging, cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor are reported.


2020 ◽  
Vol 8 (33) ◽  
pp. 7403-7412 ◽  
Author(s):  
Xuancheng Du ◽  
Weijie Wang ◽  
Chun Wu ◽  
Bingqing Jia ◽  
Weifeng Li ◽  
...  

An enzyme-responsive turn-on nanoprobe is presented for in situ fluorescence imaging and localized photothermal treatment of multidrug-resistant bacterial infections.


2013 ◽  
Vol 23 (10) ◽  
pp. 2916-2919 ◽  
Author(s):  
Mao-Zhong Tian ◽  
Ming-Ming Hu ◽  
Jiang-Li Fan ◽  
Xiao-Jun Peng ◽  
Jing-Yun Wang ◽  
...  

2017 ◽  
Vol 5 (10) ◽  
pp. 1954-1961 ◽  
Author(s):  
Mingguang Ren ◽  
Beibei Deng ◽  
Kai Zhou ◽  
Jian-Yong Wang ◽  
Xiuqi Kong ◽  
...  

We have developed a new mitochondrial-targeted turn-on fluorescent HNO probe (Mito-HNO). Fluorescence imaging shows that Mito-HNO is suitable for ratiometric visualization of HNO within mitochondria in living cells.


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