Elucidating the Molecular Interactions Occurring during Drug Precipitation of Weak Bases from Lipid-Based Formulations: A Case Study with Cinnarizine and a Long Chain Self-Nanoemulsifying Drug Delivery System

2015 ◽  
Vol 12 (11) ◽  
pp. 4067-4076 ◽  
Author(s):  
Philip J. Sassene ◽  
Mette D. Mosgaard ◽  
Korbinian Löbmann ◽  
Huiling Mu ◽  
Flemming H. Larsen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Molecular Interactions ◽  
Weak Bases ◽  
Drug Precipitation ◽  
Long Chain

A traceable porous bowl-like PLA@C-dots composite for in vitro drug delivery system: A case study of artemisinin

2015 ◽  
Vol 213 ◽  
pp. e50 ◽  
Author(s):  
Runrun Wu ◽  
Jianming Pan ◽  
Weidong Shi ◽  
Guoqing Pan ◽  
Xiaohui Dai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
System A

Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: Case study using a model drug

2014 ◽  
Vol 64 ◽  
pp. 26-36 ◽  
Author(s):  
Sarala Yanamandra ◽  
Natarajan Venkatesan ◽  
Veeran Gowda Kadajji ◽  
Zhijun Wang ◽  
Manish Issar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
First Pass Metabolism ◽  
First Pass ◽  
Model Drug ◽  
Pass Metabolism

scholarly journals Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

2015 ◽  
Vol 484 (1-2) ◽  
pp. 85-94 ◽  
Author(s):  
Pierre-Yves Sacré ◽  
Lauranne Netchacovitch ◽  
Charlotte De Bleye ◽  
Pierre-François Chavez ◽  
Cécile Servais ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Hyperspectral Imaging ◽  
Delivery System

scholarly journals Development and in vivo Evaluation Lovastatin by Self-Nanoemulsifying Drug Delivery System

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
D.V. R. N. Bhikshapathi ◽  
Keerthi Priya
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmacokinetic Studies ◽  
In Vivo Evaluation ◽  
Drug Precipitation ◽  
Capmul Mcm ◽  
Evaluation Parameters

In the present investigation, self-nanoemulsifying drug delivery system (SNEDDS), of Lovastatin is being formulated to increase the solubility and bioavailability. The optimized Lovastatin SNEDDS formulation (F8) has a composition of Acrysol EL 135 as oil phase, Lauro glycol 90 and Capmul MCM as surfactant and co-surfactant respectively. Formulation F8 was found to be best formulation based on evaluation parameters. No drug precipitation or phase separation was observed in the optimized formulation. The particle size of the optimized formulation was found to be 4.9 nm and Z-Average of 71.5 nm indicating all the particles were in the nanometer range. The zeta potential of the optimized SNEDDS formulation was found to be -13.7 mV which comply with the requirement of the zeta potential for stability. Furthermore, pharmacokinetic studies in rats indicated that compared to the pure drug, the optimized SMEDDS formulation significantly improved the oral bioavailability of Lovastatin. Therefore, from our results the study suggests that the Lovastatin loaded self-nanoemulsifying formulation has a great potential for clinical application.

Metal-organic framework MIL-101(Fe)-NH 2 functionalized with different long-chain polyamines as drug delivery system

2018 ◽  
Vol 93 ◽  
pp. 115-120 ◽  
Author(s):  
Miroslav Almáši ◽  
Vladimír Zeleňák ◽  
Peter Palotai ◽  
Eva Beňová ◽  
Adriana Zeleňáková
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Long Chain ◽  
Organic Framework

scholarly journals Alginate Metal Complexes and Their Application

2021 ◽  
Author(s):  
Ghaidaa Alkhayer
Keyword(s):  
Drug Delivery ◽  
Metal Complexes ◽  
Drug Delivery System ◽  
Organic Synthesis ◽  
Delivery System ◽  
Main Idea ◽  
Medical Application ◽  
Chiral Drugs ◽  
Multivalent Metal

Alginate is a natural polymer that can form complexes in the presence of multivalent metal. In this chapter, we summarized the newest alginate metal complexes application in many fields; organic synthesis, environmental and medical application. The main idea was about alginate complexes’ role in the drug delivery system as a chiral excipient to reach the enantioselective release in the case of chiral drugs. We also present a case study about the ketoprofen enantioselective release investigation from alginate mixed beads with two ion metal types.

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