Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery

Nano Letters ◽  
2018 ◽  
Vol 19 (1) ◽  
pp. 318-330 ◽  
Author(s):  
Xiang Ni ◽  
Xiaoyan Zhang ◽  
Xingchen Duan ◽  
Han-Liang Zheng ◽  
Xiao-Song Xue ◽  
...  
Keyword(s):  
Near Infrared ◽  
Cancer Surgery ◽  
Signal Ratio ◽  
Aggregation Induced Emission ◽  
Image Guided

High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. 1110-1114 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Shidang Xu ◽  
Shenglu Ji ◽  
Fang Hu ◽  
...  
Keyword(s):  
High Performance ◽  
Near Infrared ◽  
Anticancer Therapy ◽  
Infrared Emission ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Near Infrared Emission

A series of D–A′–π–A type photosensitizers were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously, and have been successfully used for image-guided photodynamic anticancer therapy.

Dragonfly-shaped near-infrared AIEgen with optimal fluorescence brightness for precise image-guided cancer surgery

Biomaterials ◽  
2020 ◽  
Vol 248 ◽  
pp. 120036 ◽  
Author(s):  
Ji Qi ◽  
Xingchen Duan ◽  
Wenyi Liu ◽  
Ying Li ◽  
Yuanjing Cai ◽  
...  
Keyword(s):  
Near Infrared ◽  
Cancer Surgery ◽  
Image Guided

scholarly journals Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

2017 ◽  
Vol 8 (4) ◽  
pp. 2782-2789 ◽  
Author(s):  
Jie Liu ◽  
Chao Chen ◽  
Shenglu Ji ◽  
Qian Liu ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Fluorescent Nanoparticles ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Long Wavelength ◽  
Image Guided ◽  
Fluorescent Molecules

Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

A Highly Efficient and Photostable Photosensitizer with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Anticancer Therapy

2017 ◽  
Vol 29 (33) ◽  
pp. 1700548 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Fang Hu ◽  
Shidang Xu ◽  
Chao Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Anticancer Therapy ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Highly Efficient

scholarly journals High Performance Aggregation-Induced Emission Nanoprobes for Image-Guided Cancer Surgery

2021 ◽  
Vol 79 (3) ◽  
pp. 319
Author(s):  
Heqi Gao ◽  
Di Jiao ◽  
Hanlin Ou ◽  
Jingtian Zhang ◽  
Dan Ding
Keyword(s):  
High Performance ◽  
Cancer Surgery ◽  
Aggregation Induced Emission ◽  
Image Guided

scholarly journals Image-guided cancer surgery using near-infrared fluorescence

2013 ◽  
Vol 10 (9) ◽  
pp. 507-518 ◽  
Author(s):  
Alexander L. Vahrmeijer ◽  
Merlijn Hutteman ◽  
Joost R. van der Vorst ◽  
Cornelis J. H. van de Velde ◽  
John V. Frangioni
Keyword(s):  
Near Infrared ◽  
Cancer Surgery ◽  
Near Infrared Fluorescence ◽  
Image Guided

Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

2019 ◽  
Vol 62 (11) ◽  
pp. 1472-1480 ◽  
Author(s):  
Xiaoyan Zhang ◽  
Cong Li ◽  
Wenyi Liu ◽  
Hanlin Ou ◽  
Dan Ding
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Aggregation Induced Emission ◽  
Image Guided

scholarly journals Bioinspired Long-Wavelength Excitable Near-Infrared AIEdots for Endometriosis Targeting and Image-Guided Surgery

2021 ◽  
Author(s):  
Huashan Zhao ◽  
Chunbin Li ◽  
Wen Zhu ◽  
Ming Yu ◽  
Binbin Huang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Imaging System ◽  
Small Animal Imaging ◽  
Pharmacological Intervention ◽  
Surgical Removal ◽  
Signal Ratio ◽  
Vitro Assay ◽  
Image Guided

Endometriosis（EM）is a non-cancerous and intractable disease in clinic due to the ambiguity of its etiology and mechanism. Surgical removal of the lesions is more efficient method for EM treatment compared with pharmacological intervention. Intraoperative identification of the endometrial ectopic sites is a prerequisite, however, available probes with high specificity remain limited, owing to lack of specific biomarkers. Here, based on a polypeptide derived from VAR2CSA protein (CSA) and a near-infrared AIE material (TPA-TBZ-2), we prepared a CSA AIEdots capable of labeling the EM lesions by a one-step nanoprecipitation method. The nanodots have an absorbance maximum at 610 nm with a wide emission range from 650 to 850 nm and an absolute quantum yield of up to 34% in the aggregation states. Through in vitro assay, the dots could specifically label endometrioid cells (Ishikawa cells), and flow cytometry experiments showed its specific spectral absorption peak, compared with empty particles and scrambled peptide groups. Next, to verify the ability of the dots to label the ectopic endometrium in vivo, we established a mouse model of endometriosis. After injection the dots into model mouse intravenously for 24 hours, the AIE signaling could be specifically detected at the ectopic lesions in an IVIS small animal imaging system. The CSA AIEdots were further used for image-guided EM resection in vivo and showed a high EM-to-normal tissue signal ratio. Taken together, our AIE nanodots-based EM diagnosis system is a promising candidate for EM development monitoring and surgical navigations. <br>

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