“Internal and External Combined” Nonradiative Decay-Based Nanoagents for Photoacoustic Image-Guided Highly Efficient Photothermal Therapy

2021 ◽  
Author(s):  
Hua Gu ◽  
Weijian Liu ◽  
Shijie Zhen ◽  
Saran Long ◽  
Wen Sun ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Nonradiative Decay ◽  
Image Guided ◽  
Highly Efficient

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

A Highly Specific Multiple Enhancement Theranostic Nanoprobe for PET/MRI/PAI Image‐Guided Radioisotope Combined Photothermal Therapy in Prostate Cancer

Small ◽  
2021 ◽  
pp. 2100378
Author(s):  
Lei Xia ◽  
Xiangxi Meng ◽  
Li Wen ◽  
Nina Zhou ◽  
Teli Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Photothermal Therapy ◽  
Image Guided

Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics

2021 ◽  
pp. 2102799
Author(s):  
Xiaozhen Li ◽  
Di Zhang ◽  
Guihong Lu ◽  
Tingchao He ◽  
Yingpeng Wan ◽  
...  
Keyword(s):  
Small Molecules ◽  
Photochemical Synthesis ◽  
Nonradiative Decay ◽  
Highly Efficient

scholarly journals Carambola-like Bi2Te3 superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the sencond biowindow

2021 ◽  
Author(s):  
Yinghui Wang ◽  
Ying Zhao ◽  
Yang Liu ◽  
Qishun Wang ◽  
Jianhua Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient ◽  
Penetration Ability ◽  
Maximum Permissible Exposure

Photothermal therapy (PTT) stimulated by the lights in the second near-infrared (NIR-II) biowindow shows great superiorities in penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents...

Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO2 Nanosheets

2019 ◽  
Vol 11 (6) ◽  
pp. 6267-6275 ◽  
Author(s):  
Li Wang ◽  
Shanyue Guan ◽  
Yangziwan Weng ◽  
Si-Min Xu ◽  
Heng Lu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Mno2 Nanosheets ◽  
Highly Efficient

Porous cobalt sulfide hollow nanospheres with tunable optical property for magnetic resonance imaging-guided photothermal therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14190-14200 ◽  
Author(s):  
Guoqiang Guan ◽  
Xin Wang ◽  
Xiaojuan Huang ◽  
Wenlong Zhang ◽  
Zhe Cui ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optical Property ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Cobalt Sulfide ◽  
Resonance Imaging ◽  
Hollow Nanospheres ◽  
Highly Efficient ◽  
Tunable Absorption

Simple, highly efficient, and safe porous cobalt sulfide hollow nanospheres with tunable absorption as a magnetic resonance imaging-guided photothermal theranostic platform.

Collective Plasmon Coupling in Gold Nanoparticle Clusters for Highly Efficient Photothermal Therapy

ACS Nano ◽  
2022 ◽  
Author(s):  
Jinxing Chen ◽  
Mingfu Gong ◽  
Yulong Fan ◽  
Ji Feng ◽  
Lili Han ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Photothermal Therapy ◽  
Plasmon Coupling ◽  
Highly Efficient ◽  
Nanoparticle Clusters

scholarly journals Nanococktail Based on AIEgens and Semiconducting Polymers: A Single Laser Excited Image-Guided Dual Photothermal Therapy

Theranostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2260-2272 ◽  
Author(s):  
Zi Long ◽  
Jun Dai ◽  
Qinyu Hu ◽  
Quan Wang ◽  
Shijie Zhen ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Semiconducting Polymers ◽  
Image Guided ◽  
Single Laser

scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

Sign in / Sign up

Export Citation Format

Share Document