Carbon-Dot-Coated Alginate Beads as a Smart Stimuli-Responsive Drug Delivery System

2016 ◽  
Vol 8 (50) ◽  
pp. 34179-34184 ◽  
Author(s):  
Sristi Majumdar ◽  
Gargee Krishnatreya ◽  
Neelam Gogoi ◽  
Debajit Thakur ◽  
Devasish Chowdhury
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Alginate Beads ◽  
Stimuli Responsive ◽  
Carbon Dot

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

2016 ◽  
Vol 43 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Muhammad Tahir Haseeb ◽  
Muhammad Ajaz Hussain ◽  
Sajid Bashir ◽  
Muhammad Umer Ashraf ◽  
Naveed Ahmad
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Release Drug

scholarly journals Antibacterial Activity of Mucoadhesive Gastroretentive Drug Delivery System of Alginate Beads Containing Turmeric Extract - PVP Solid Dispersion

2019 ◽  
Vol 7 (22) ◽  
pp. 3868-3873
Author(s):  
Hakim Bangun ◽  
Anayanti Arianto ◽  
Yuni Sari Bangun ◽  
Marline Nainggolan
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Dispersion ◽  
Alginate Beads ◽  
Diffusion Method ◽  
Turmeric Extract

BACKGROUND: Turmeric extract is less effective because the main ingredient of curcumin has a low solubility. Therefore, it is necessary to convert turmeric extract into a solid dispersion form to increase the dissolution of curcumin. AIM: To determine the antibacterial activity of mucoadhesive gastroretentive drug delivery system of alginate beads containing solid dispersion of turmeric extract. METHODS: Turmeric powder was macerated with 96% ethanol for 8 days. The macerate was evaporated with a rotary evaporator at 50°C to obtain concentrated extract. Solid dispersion of turmeric extract was prepared by solvent method by using polyvinylpyrrolidone (PVP) K30 with a ratio of 1: 1 and 1: 2. The solid dispersion of turmeric extract was encapsulated with alginate gel by gelation method. The antibacterial of alginate beads containing solid dispersion of turmeric extract was tested by using hole agar plate diffusion method against Staphylococcus aureus and Escherichia coli as bacterial models. RESULTS: The size of alginate beads containing turmeric extract-PVP solid dispersion was about 1.3 mm. Antibacterial activity test against Staphylococcus aureus and Escherichia coli showed that alginate beads containing turmeric extract-PVP solid dispersion gave stronger antibacterial activity than those containing turmeric extract without solid dispersion. The antibacterial activity of alginate beads turmeric extract-PVP (1: 2) solid dispersion was stronger than those containing turmeric-extract (1: 1) solid dispersion. CONCLUSION: Based on the results of this study it can be concluded that alginate beads containing turmeric extract-PVP solid dispersion gives the stronger antibacterial activity than those containing turmeric extract without solid dispersion.

scholarly journals PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY

2019 ◽  
Vol 12 (1) ◽  
pp. 316
Author(s):  
Hakim Bangun ◽  
Fadlina Aulia ◽  
Anayanti Arianto ◽  
Marline Nainggolan
Keyword(s):  
Drug Delivery ◽  
Gastric Ulcer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Alginate Beads ◽  
Male Rats ◽  
Gastric Lesions ◽  
Turmeric Extract ◽  
The Mean

Objectives: The objectives of this study were to prepare the mucoadhesive mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract and to evaluate its anti-gastric effect.Methods: Turmeric extract was made by macerating turmeric powder in ethanol 96% and evaporated using rotary evaporator at 50°C to obtained concentrated extract. Then, it was prepared alginate beads containing 5% turmeric extract by gelation method. The mucoadhesive properties of alginate beads containing turmeric extract were tested in vitro in male rats and the anti-gastric ulcer effect was tested on HCl-induced gastric ulcer in rats.Results: The mean diameter of alginate beads obtained was 1.13±0.19 mm. Bioadhesion test showed that alginate beads containing turmeric extract could be attached on gastric rats mucosa. Anti-gastric ulcer test showed that the healing of gastric lesions in rats was faster using alginate beads containing turmeric extract compared to untreated ones.Conclusions: The results of this study suggest that mucoadhesive drug delivery systems of alginate beads containing turmeric extract are potentially developed as an anti-gastric ulcer.

scholarly journals Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

2020 ◽  
Vol 7 ◽  
Author(s):  
Reju George Thomas ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Stimuli Responsive ◽  
Redox Enzyme ◽  
Nano Drug Delivery ◽  
Different Types ◽  
Internal Ph ◽  
Stimuli Response

Cancer is a disease that affects a large number of people all over the world. For treating cancer, nano-drug delivery system has been introduced recently with objective of increasing therapeutic efficiency of chemotherapeutic drug. The main characteristics of this system are the encapsulation of the insoluble chemotherapeutic cargo, increasing the period of circulation in the body, as well as the delivery of the drug at that specific site. Currently, the nano-drug delivery system based on the stimuli response is becoming more popular because of the extra features for controlling the drug release based on the internal atmosphere of cancer. This review provides a summary of different types of internal (pH, redox, enzyme, ROS, hypoxia) stimuli-responsive nanoparticle drug delivery systems as well as perspective for upcoming times.

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