Dual-Responsive Bola-Type Supra-Amphiphile Constructed from Water-Soluble Pillar[5]arene and Naphthalimide-Containing Amphiphile for Intracellular Drug Delivery

2017 ◽  
Vol 9 (5) ◽  
pp. 4843-4850 ◽  
Author(s):  
Xin Liu ◽  
Keke Jia ◽  
Yichen Wang ◽  
Wei Shao ◽  
Chenhao Yao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

Design and synthesis of redox and oxidative dual responsive block copolymer micelles for intracellular drug delivery

2016 ◽  
Vol 85 ◽  
pp. 38-52 ◽  
Author(s):  
Changyu He ◽  
Qinglai Yang ◽  
Lianjiang Tan ◽  
Bingya Liu ◽  
Zhenggang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Design And Synthesis ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

scholarly journals Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 604 ◽  
Author(s):  
Young Choi ◽  
Eun-sook Choi ◽  
Kwan Mun ◽  
Se Lee ◽  
Sung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Therapeutic Effects ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Efficient Delivery ◽  
Poly Ethylene ◽  
Oxidation Of Methionine

Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies.

pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 63070-63078 ◽  
Author(s):  
Shuangjiang Yu ◽  
Chaoliang He ◽  
Qiang Lv ◽  
Hai Sun ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Reducing Agent ◽  
Acidic Environment ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
System P

pH- and reduction-responsive disulfide-crosslinked polyurethane micelles (CL-PUMs) were developed. The CL-PUMs remained stable in normal PBS while selectively swelled or decomposed in response to weakly acidic environment or reducing agent.

pH and reduction dual-responsive nanogel cross-linked by quaternization reaction for enhanced cellular internalization and intracellular drug delivery

2013 ◽  
Vol 4 (4) ◽  
pp. 1199-1207 ◽  
Author(s):  
Mingqiang Li ◽  
Zhaohui Tang ◽  
Hai Sun ◽  
Jianxun Ding ◽  
Wantong Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cellular Internalization ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

Acid/light dual-responsive biodegradable polymeric nanocarriers for efficient intracellular drug delivery

2018 ◽  
Vol 76 (4) ◽  
pp. 1775-1792 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Xiang Cao ◽  
Tian Liang ◽  
Zhiwei Tong
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanocarriers ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery

Soft Matter ◽  
2013 ◽  
Vol 9 (9) ◽  
pp. 2637 ◽  
Author(s):  
Shuangjiang Yu ◽  
Chaoliang He ◽  
Jianxun Ding ◽  
Yilong Cheng ◽  
Wantong Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Triblock Copolymers ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

scholarly journals Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

2017 ◽  
Vol 5 (48) ◽  
pp. 9497-9501 ◽  
Author(s):  
Mingyang Hei ◽  
Jun Wang ◽  
Kelly Wang ◽  
Weiping Zhu ◽  
Peter X. Ma
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bonds ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Upper Critical Solution Temperature

A novel, dual responsive and intracellular delivery system was developed by grafting UCST-type polymers onto the surface of mesoporous silica nanoparticles through disulfide bonds.

Dual responsive supramolecular nanogels for intracellular drug delivery

2014 ◽  
Vol 50 (29) ◽  
pp. 3789 ◽  
Author(s):  
Xiaofei Chen ◽  
Li Chen ◽  
Xuemei Yao ◽  
Zhe Zhang ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dual Responsive ◽  
Intracellular Drug Delivery

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

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