An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
Keyword(s):
AbstractHow to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy.
2018 ◽
Vol 6
(39)
◽
pp. 6269-6277
◽
2017 ◽
Vol 253
◽
pp. 96-101
◽
2017 ◽
pp. 593-621
◽
2020 ◽
Vol 189
◽
pp. 110832
◽
2010 ◽
Vol 31
(12)
◽
pp. 3335-3346
◽
2018 ◽
Vol 9
(3)
◽
pp. 035007
◽