Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

2018 ◽  
Vol 10 (43) ◽  
pp. 36711-36720 ◽  
Author(s):  
Roi Rutenberg ◽  
Daria Galaktionova ◽  
Gilad Golden ◽  
Yael Cohen ◽  
Yael Levi-Kalisman ◽  
...  
Keyword(s):  
Molecular Delivery

Designing a molecular delivery system within a preclinical timeframe

2007 ◽  
Vol 12 (5-6) ◽  
pp. 189-199 ◽  
Author(s):  
Jan-Olav Henck ◽  
Stephen R. Byrn
Keyword(s):  
Delivery System ◽  
Molecular Delivery

scholarly journals Preface to Special Issue on Roles of Optics and Laser Technology in Molecular Delivery

2017 ◽  
Vol 45 (11) ◽  
pp. 684
Author(s):  
Shunichi SATO
Keyword(s):  
Special Issue ◽  
Laser Technology ◽  
Molecular Delivery

Surface Patterning: Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro- and Nanopatterned Surfaces(Adv. Funct. Mater. 18/2009)

2009 ◽  
Vol 19 (18) ◽  
pp. NA-NA
Author(s):  
Eric Stern ◽  
Steven M. Jay ◽  
Stacey L. Demento ◽  
Ryan P. Murelli ◽  
Mark A. Reed ◽  
...  
Keyword(s):  
Surface Patterning ◽  
Molecular Delivery ◽  
Spatiotemporal Control

scholarly journals Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Eisaku Kondo ◽  
Ken Saito ◽  
Yuichi Tashiro ◽  
Kaeko Kamide ◽  
Shusei Uno ◽  
...  
Keyword(s):  
Cell Penetrating Peptides ◽  
Delivery Systems ◽  
Molecular Delivery ◽  
Cell Penetrating

Molecular delivery systems using macrocyclic sugar clusters

1998 ◽  
Vol 70 (12) ◽  
pp. 2379-2384 ◽  
Author(s):  
Y. Aoyama ◽  
Yusuke Matsuda ◽  
Jirarut Chuleeraruk ◽  
K. Nishiyama ◽  
Kazuhisa Fujimoto ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Molecular Delivery

scholarly journals Nanostructure Empowers Active Tumor Targeting in Ligand‐Based Molecular Delivery

2019 ◽  
Vol 36 (11) ◽  
pp. 1900304 ◽  
Author(s):  
Hèctor López‐Laguna ◽  
Rita Sala ◽  
Julieta M. Sánchez ◽  
Patricia Álamo ◽  
Ugutz Unzueta ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Molecular Delivery

scholarly journals Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Timothy M. OʼShea ◽  
Alexander L. Wollenberg ◽  
Jae H. Kim ◽  
Yan Ao ◽  
Timothy J. Deming ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Foreign Body ◽  
Molecular Mechanisms ◽  
Host Cells ◽  
Peripheral Tissues ◽  
Molecular Delivery ◽  
Wound Responses ◽  
The Central Nervous System

AbstractBiomaterials hold promise for therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo, or about how such responses influence biomaterial function. Here, we probed these factors in mice using a platform of injectable hydrogels readily modified to present interfaces with different physiochemical properties to host cells. We found that biomaterial FBRs mimic specialized multicellular CNS wound responses not present in peripheral tissues, which serve to isolate damaged neural tissue and restore barrier functions. We show that the nature and intensity of CNS FBRs are determined by definable properties that significantly influence hydrogel functions, including resorption and molecular delivery when injected into healthy brain or stroke injuries. Cationic interfaces elicit stromal cell infiltration, peripherally derived inflammation, neural damage and amyloid production. Nonionic and anionic formulations show minimal levels of these responses, which contributes to superior bioactive molecular delivery. Our results identify specific molecular mechanisms that drive FBRs in the CNS and have important implications for developing effective biomaterials for CNS applications.

Orthogonally Regulated Mechanical Strength and Molecular Delivery Capabilities Achieved in a Double Network Hydrogel Matrix

2020 ◽  
Vol 5 (19) ◽  
pp. 5781-5787
Author(s):  
Kaixuan Teng ◽  
Xinglong Luan ◽  
Qi An ◽  
Yantao Zhao ◽  
Xiantong Hu ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Double Network ◽  
Molecular Delivery ◽  
Hydrogel Matrix

Aminoglycoside-derived amphiphilic nanoparticles for molecular delivery

2016 ◽  
Vol 146 ◽  
pp. 924-937 ◽  
Author(s):  
Bhavani Miryala ◽  
Sudhakar Godeshala ◽  
Taraka Sai Pavan Grandhi ◽  
Matthew D. Christensen ◽  
Yanqing Tian ◽  
...  
Keyword(s):  
Molecular Delivery ◽  
Amphiphilic Nanoparticles

The Role of Ion Electrophoresis in Electroporation-Mediated Molecular Delivery

2009 ◽  
Author(s):  
Jianbo Li ◽  
Hao Lin
Keyword(s):  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Stem Cell Differentiation ◽  
Equation System ◽  
Cellular Membrane ◽  
Dominant Mode ◽  
Ovary Cells ◽  
Fluorescence Measurements ◽  
Molecular Delivery

Electroporation is a widely applied technique to deliver active molecules into the cellular compartment, to perform tasks such as gene therapy and directed stem cell differentiation, among many others. In this technique, an electric field transiently permeabilizes the cellular membrane to facilitate molecular exchange. While the permeabilization process is relatively well understood, the transport mechanisms for molecular delivery are still under debate. In this work, the role of ion electrophoresis in electroporation-mediated molecular delivery is investigated using numerical simulation. The Nernst-Planck equations for ionic transport in the extracellular and intracellular spaces are solved, respectively, and are coupled through a permeabilization model on the membrane. For the latter, an asymptotic Smoluchowski equation system is adopted, following the work of Krassowska and co-authors. The simulation is used to investigate the delivery of calcium ions into Chinese hamster ovary cells. The results indicate that ion electrophoresis is the dominant mode of transport in the delivery of small charged molecules. Furthermore, the achievable intracellular concentration is strongly influenced by the conductivity difference between the cytoplasm and the buffer, a phenomenon known as “field-amplified sample stacking”. The results agree qualitatively with the fluorescence measurements by Gabriel and Teissie´ (1999), and suggest a new possibility to simultaneously improve cell viability and efficiency in electroporation-mediated molecular delivery.

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