Endovascular Stem Cell Therapy Post Stroke Rescues Neurons from Endoplasmic Reticulum Stress-Induced Apoptosis by Modulating Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Signaling

2021 ◽  
Author(s):  
Harpreet Kaur ◽  
Deepaneeta Sarmah ◽  
Pabbala Veeresh ◽  
Aishika Datta ◽  
Kiran Kalia ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Stem Cell ◽  
Endoplasmic Reticulum Stress ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Receptor Kinase ◽  
Post Stroke ◽  
Induced Apoptosis

A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies

2021 ◽  
Vol 19 ◽  
Author(s):  
Aditya A Singh ◽  
Akash Kharwar ◽  
Manoj P. Dandekar
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Neurotrophic Factors ◽  
Treatment Strategies ◽  
Experimental Models ◽  
Cerebral Stroke ◽  
Post Stroke ◽  
Stroke Models

Background: Stroke is a serious neurovascular problem and the leading cause of disability and death worldwide. The disrupted demand to supply ratio of blood and glucose during cerebral ischemia develops hypoxic shock, and subsequently necrotic neuronal death in the affected regions. Multiple causal factors like age, sex, race, genetics, diet, and lifestyle play an important role in the occurrence as well as progression of post-stroke deleterious events. These biological and environmental factors may be contributed to vasculature variable architecture and abnormal neuronal activity. Since recombinant tissue plasminogen activator is the only clinically effective clot bursting drug, there is a huge unmet medical need for newer therapies for the treatment of stroke. Innumerous therapeutic interventions have shown promise in the experimental models of stroke but failed to translate it into clinical counterparts. Methods: Original publications regarding pathophysiology, preclinical experimental models, new targets and therapies targeting ischemic stroke have been reviewed since the 1970s. Results: We highlighted the critical underlying pathophysiological mechanisms of cerebral stroke and preclinical stroke models. We discuss the strengths and caveats of widely used ischemic stroke models, and commented on the potential translational problems. We also describe the new emerging treatment strategies, including stem cell therapy, neurotrophic factors and gut microbiome-based therapy for the management of post-stroke consequences. Results : We highlighted the critical underlying pathophysiological mechanisms of cerebral stroke and preclinical stroke models. We discuss the strengths and caveats of widely used ischemic stroke models, and commented on the potential translational problems. We also describe the new emerging treatment strategies, including stem cell therapy, neurotrophic factors and gut microbiome-based therapy for the management of post-stroke consequences. Conclusion: There are still many inter-linked pathophysiological alterations with regards to stroke, animal models need not necessarily mimic the same conditions of stroke pathology and newer targets and therapies are the need of the hour in stroke research.

Modulation of Post-Stroke Plasticity and Regeneration by Stem Cell Therapy and Exogenic Factors

2017 ◽  
pp. 129-152 ◽  
Author(s):  
Lukas Andereggen ◽  
Raluca Reitmeir ◽  
Stefano Di Santo ◽  
Raphael Guzman ◽  
Hans R. Widmer ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Post Stroke

Prevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neurons

2004 ◽  
Vol 1028 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Koji Shimoke ◽  
Takahiro Utsumi ◽  
Soichiro Kishi ◽  
Manabu Nishimura ◽  
Harue Sasaya ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Brain Derived Neurotrophic Factor ◽  
Cerebral Cortical Neurons
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