scholarly journals Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Assaf Zinger ◽  
Manuela Sushnitha ◽  
Tomoyuki Naoi ◽  
Gherardo Baudo ◽  
Enrica De Rosa ◽  
...  
Keyword(s):  
Biomimetic Nanoparticles ◽  
Inflammation Targeting

scholarly journals Biomimetic nanoparticles for inflammation targeting

2018 ◽  
Vol 8 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Kai Jin ◽  
Zimiao Luo ◽  
Bo Zhang ◽  
Zhiqing Pang
Keyword(s):  
Biomimetic Nanoparticles ◽  
Inflammation Targeting

scholarly journals Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small ◽  
2021 ◽  
pp. 2006484
Author(s):  
Fatemeh Oroojalian ◽  
Mohammad Beygi ◽  
Behzad Baradaran ◽  
Ahad Mokhtarzadeh ◽  
Mohammad‐Ali Shahbazi
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Immune Cell ◽  
Targeted Cancer Therapy ◽  
Biomimetic Nanoparticles

scholarly journals A20 inhibition of NFκB and inflammation: Targeting E2:E3 ubiquitin enzyme complexes

Cell Cycle ◽  
2010 ◽  
Vol 9 (13) ◽  
pp. 2481-2482 ◽  
Author(s):  
Noula Shembade ◽  
Edward Harhaj
Keyword(s):  
Inflammation Targeting ◽  
Enzyme Complexes

scholarly journals A Simple Self-Adjuvanting Biomimetic Nanovaccine Self-Assembled with the Conjugate of Phospholipids and Nucleotides Can Induce Strong Cancer Immunotherapeutic Effect

2020 ◽  
Author(s):  
Dan Liu ◽  
Jiale Liu ◽  
Bing Ma ◽  
Bo Deng ◽  
Haiyan Xu ◽  
...  
Keyword(s):  
Suppressive Effect ◽  
Cpg Odn ◽  
Mhc I ◽  
Cross Presentation ◽  
Biomimetic Nanoparticles ◽  
Potential Applications ◽  
Survival Prolongation ◽  
Self Assembled ◽  
Cancer Immunotherapeutic ◽  
Cellular Immune

Abstract Background: Biomimetic nanoparticles have potential applications in many fields for their favorable properties. Results: Here, we developed a self-adjuvanting biomimetic anti-tumor nanovaccine, which was self-assembled with an amphiphilic conjugate synthetized with phospholipids of 1, 2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and hydrophilic Toll-like receptor (TLR9) agonists CpG ODN. The nanovaccine could not only provide effective initial antigens stimulation and sustained long-term antigen supply with a controlled release, but also induce antigens cross-presentation via MHC-I pathway initiating CD8+ T-cell responses. Moreover, the dense nucleotides shell around the nanovaccine could promote antigens endocytosis via various receptor-mediated pathways into dendritic cells. And CpG ODN interacted with TLR9 triggering the cytokines secretion of TNF-α and IL-10 further boosted the anti-tumor humoral and cellular immune responses, which led to significant tumor suppressive effect and remarkable survival prolongation. Conclusions: So, this nanovaccine self-assembled with phospholipid-nucleotide amphiphiles can serve as a safe, simple and efficient approach for anti-tumor immunotherapy.

scholarly journals Ultra‐Small Biomimetic Nanoparticles for Alzheimer’s Disease Targeted Drug Delivery

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Katyayani Tatiparti ◽  
Mohd Ahmar Rauf ◽  
Samaresh Sau ◽  
R. Alzhrani ◽  
Arun Iyer
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Targeted Drug Delivery ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug

Engineering of stimuli-responsive self-assembled biomimetic nanoparticles

2021 ◽  
pp. 114006
Author(s):  
Nishta Krishnan ◽  
Ronnie H. Fang ◽  
Liangfang Zhang
Keyword(s):  
Stimuli Responsive ◽  
Biomimetic Nanoparticles ◽  
Self Assembled

scholarly journals Cell-derived biomimetic nanoparticles as a novel drug delivery system for atherosclerosis: predecessors and perspectives

2020 ◽  
Vol 7 (4) ◽  
pp. 349-358
Author(s):  
Long Yang ◽  
Guangchao Zang ◽  
Jingwen Li ◽  
Xinyue Li ◽  
Yuanzhu Li ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Drug Delivery ◽  
Precision Medicine ◽  
Blood Circulation ◽  
Drug Delivery Systems ◽  
High Morbidity ◽  
Whole Cells ◽  
Biomimetic Nanoparticles ◽  
Novel Drug Delivery System ◽  
Novel Drug

Abstract Atherosclerosis is a key mechanism underlying the pathogenesis of cardiovascular disease, which is associated with high morbidity and mortality. In the field of precision medicine for the treatment of atherosclerosis, nanoparticle (NP)-mediated drug delivery systems have great potential, owing to their ability to release treatment locally. Cell-derived biomimetic NPs have attracted extensive attention at present due to their excellent targeting to atherosclerotic inflammatory sites, low immunogenicity and long blood circulation time. Here, we review the utility of cell-derived biomimetic NPs, including whole cells, cell membranes and extracellular vesicles, in the treatment of atherosclerosis.

Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages

Nanoscale ◽  
2019 ◽  
Vol 11 (42) ◽  
pp. 20206-20220 ◽  
Author(s):  
Shulan Han ◽  
Wenjie Wang ◽  
Shengfang Wang ◽  
Shuo Wang ◽  
Ruijun Ju ◽  
...  
Keyword(s):  
Immune System ◽  
Tumor Cells ◽  
Immune Tolerance ◽  
Drug Efficacy ◽  
Tumor Associated Macrophages ◽  
Biomimetic Nanoparticles

Immunosuppression and immune tolerance lead tumor cells to evade immune system surveillance and weaken drug efficacy.

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