Quick and Mild Isolation of Intact Lysosomes Using Magnetic–Plasmonic Hybrid Nanoparticles

ACS Nano ◽  
2022 ◽  
Author(s):  
The Son Le ◽  
Mari Takahashi ◽  
Noriyoshi Isozumi ◽  
Akio Miyazato ◽  
Yuichi Hiratsuka ◽  
...  
Keyword(s):  
Hybrid Nanoparticles

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

scholarly journals Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2034 ◽  
Author(s):  
Christian D. Siewert ◽  
Heinrich Haas ◽  
Vera Cornet ◽  
Sara S. Nogueira ◽  
Thomas Nawroth ◽  
...  
Keyword(s):  
Small Angle ◽  
Messenger Rna ◽  
Physicochemical Characterization ◽  
Single Step ◽  
Model Systems ◽  
Molecular Organization ◽  
Hybrid Nanoparticles ◽  
Polymer Mixture ◽  
Internal Organization ◽  
Transfection Efficacy

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two different sequential assembly approaches in comparison with a direct single-step protocol were applied, and molecular organization in correlation with biological activity of the resulting nanoparticle systems was investigated. Differences in the structure of the nanoparticles were revealed by thorough physicochemical characterization including small angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). All hybrid systems, combining lipid and polymer, displayed significantly increased transfection in comparison to lipid/mRNA and polymer/mRNA particles alone. For the hybrid nanoparticles, characteristic differences regarding the internal organization, release characteristics, and activity were determined depending on the assembly route. The systems with the highest transfection efficacy were characterized by a heterogenous internal organization, accompanied by facilitated release. Such a system could be best obtained by the single step protocol, starting with a lipid and polymer mixture for nanoparticle formation.

Dual stimuli-responsive fungicide carrier based on hollow mesoporous silica/hydroxypropyl cellulose hybrid nanoparticles

2021 ◽  
pp. 125513
Author(s):  
Yunhao Gao ◽  
Yu Liu ◽  
Xueyin Qin ◽  
Ziping Guo ◽  
Donglin Li ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Hydroxypropyl Cellulose ◽  
Hybrid Nanoparticles ◽  
Stimuli Responsive ◽  
Hollow Mesoporous Silica

scholarly journals HOXB7 siRNA delivered by hybrid nanoparticles and the co-therapy with tamoxifen: promising strategy against hormone receptor positive breast cancer

2020 ◽  
Author(s):  
Frederico Pittella ◽  
Ana Beatriz Valle ◽  
Ana Cristina Gualberto ◽  
Kézia Ferreira ◽  
Tânia Pasa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Hybrid Nanoparticles ◽  
Hormone Receptor Positive ◽  
Promising Strategy ◽  
Positive Breast Cancer

Hall and Ion Slip Currents’ Impact on Electromagnetic Blood Flow Conveying Hybrid Nanoparticles Through an Endoscope with Peristaltic Waves

2021 ◽  
Author(s):  
S. Das ◽  
B. Barman ◽  
R. N. Jana ◽  
O. D. Makinde
Keyword(s):  
Blood Flow ◽  
Hybrid Nanoparticles ◽  
Ion Slip

scholarly journals Rational Design of Ag/ZnO Hybrid Nanoparticles on Sericin/Agarose Composite Film for Enhanced Antimicrobial Applications

2020 ◽  
Vol 22 (1) ◽  
pp. 105
Author(s):  
Wanting Li ◽  
Zixuan Huang ◽  
Rui Cai ◽  
Wan Yang ◽  
Huawei He ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Antimicrobial Activity ◽  
Composite Film ◽  
Water Absorption ◽  
Rational Design ◽  
Hybrid Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray

Silver-based hybrid nanomaterials are receiving increasing attention as potential alternatives for traditional antimicrobial agents. Here, we proposed a simple and eco-friendly strategy to efficiently assemble zinc oxide nanoparticles (ZnO) and silver nanoparticles (AgNPs) on sericin-agarose composite film to impart superior antimicrobial activity. Based on a layer-by-layer self-assembly strategy, AgNPs and ZnO were immobilized on sericin-agarose films using the adhesion property of polydopamine. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray powder diffraction spectroscopy were used to show the morphology of AgNPs and ZnO on the surface of the composite film and analyze the composition and structure of AgNPs and ZnO, respectively. Water contact angle, swelling ratio, and mechanical property were determined to characterize the hydrophilicity, water absorption ability, and mechanical properties of the composite films. In addition, the antibacterial activity of the composite film was evaluated against Gram-positive and Gram-negative bacteria. The results showed that the composite film not only has desirable hydrophilicity, high water absorption ability, and favorable mechanical properties but also exhibits excellent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has shown great potential as a novel antimicrobial biomaterial for wound dressing, artificial skin, and tissue engineering.

Preparation and Evaluation of Lecithin/Zein Hybrid Nanoparticles for the Oral Delivery of Panax Notoginseng Saponins

2021 ◽  
pp. 105882
Author(s):  
Wen Fu ◽  
Yiping Liang ◽  
Zhonghui Xie ◽  
Hangyi Wu ◽  
Zhenhai Zhang ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Panax Notoginseng ◽  
Hybrid Nanoparticles ◽  
Panax Notoginseng Saponins ◽  
Preparation And Evaluation
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