Noninvasive Visualization of Sub-5 mm Orthotopic Hepatic Tumors by a Nanoprobe-Mediated Positive and Reverse Contrast-Balanced Imaging Strategy

Plane Wave Imaging (PWI) has been recently proposed for fast ultrasound inspections in the Non-Destructive-Testing (NDT) field. By using a single (or a reduced number) of plane wave emissions and parallel beamforming in reception, frame rates of hundreds to thousands of images per second can be achieved without significant image quality losses with regard to the Total Focusing Method (TFM) or Phased Array (PA). This work addresses the problem of applying PWI in the presence of arbitrarily shaped interfaces, which is a common problem in NDT. First, the mathematical formulation for generating a plane wave inside a component of arbitrary geometry is given, and the characteristics of the resultant acoustic field are analyzed by simulation, showing plane wavefronts with non-uniform amplitude. Then, an imaging strategy is proposed, accounting for this amplitude effect. Finally, the proposed method is experimentally validated, and its application limits are discussed.

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Electromagnetic Navigation System-Guided Microwave Ablation of Hepatic Tumors: A Matched Cohort Study

CardioVascular and Interventional Radiology ◽

10.1007/s00270-020-02761-6 ◽

2021 ◽

Author(s):

K. I. Ringe ◽

G. H. Pöhler ◽

H. Rabeh ◽

F. Wacker

Keyword(s):

Cohort Study ◽

Navigation System ◽

Microwave Ablation ◽

Matched Cohort ◽

Hepatic Tumors ◽

Electromagnetic Navigation ◽

Matched Cohort Study ◽

Electromagnetic Navigation System

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The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study.

BMJ Open ◽

10.1136/bmjopen-2018-027772 ◽

2019 ◽

Vol 9 (9) ◽

pp. e027772 ◽

Cited By ~ 3

Author(s):

GAM Govaert ◽

MGG Hobbelink ◽

IHF Reininga ◽

P Bosch ◽

TC Kwee ◽

...

Keyword(s):

Cohort Study ◽

The Netherlands ◽

Diagnostic Imaging ◽

Fdg Pet ◽

Imaging Techniques ◽

Time Frame ◽

Imaging Modalities ◽

Multicenter Cohort Study ◽

Discriminative Ability ◽

Imaging Strategy

IntroductionThe optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysisThis study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and disseminationApproval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.Trial registration numberThe IFI trial is registered in the Netherlands Trial Register (NTR7490).

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Hepatic Myoepithelial Carcinoma in a Dog: Immunohistochemical Comparison With Other Canine Hepatic Carcinomas

Veterinary Pathology ◽

10.1177/0300985819854439 ◽

2019 ◽

Vol 56 (6) ◽

pp. 889-894

Author(s):

Yuka Tsuji ◽

Mizuki Kuramochi ◽

Takeshi Izawa ◽

Hideo Akiyoshi ◽

Jyoji Yamate ◽

...

Keyword(s):

Smooth Muscle Actin ◽

Myoepithelial Cells ◽

Left Lobe ◽

Myoepithelial Carcinoma ◽

Hepatic Tumors ◽

Muscle Actin ◽

Hepatic Carcinoma ◽

Neoplastic Cells ◽

Immunohistochemical Studies ◽

Vacuolated Cytoplasm

An 11-year-old female miniature Dachshund dog presented with a solid, soft, gray mass on the hepatic lateral left lobe. Histologically, the mass consisted of neoplastic proliferation of cells with round nuclei and eosinophilic and vacuolated cytoplasm arranged in alveolar, trabecular, and solid patterns. Immunohistochemically, the neoplastic cells were positive for pancytokeratin (CK AE1/AE3), CK5, CK14, vimentin, Sox9, and myoepithelial markers (α–smooth muscle actin, p63, and calponin). The morphological and immunohistochemical findings indicated a diagnosis of myoepithelial carcinoma. We conducted immunohistochemical studies on other representative canine hepatic tumors. Although the myoepithelial phenotype was not observed in the hepatocellular carcinoma, some tumor cells in cholangiocarcinoma showed immunohistochemical features of myoepithelium, suggesting that some neoplastic cells in cholangiocarcinoma may have the potential to differentiate into myoepithelial cells. To our knowledge, this is the first report in veterinary medicine of a hepatic carcinoma with a myoepithelial phenotype.

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