Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy

Advanced Functional Materials ◽

10.1002/adfm.201301045 ◽

2013 ◽

Vol 23 (47) ◽

pp. 5893-5902 ◽

Cited By ~ 188

Author(s):

Liang Cheng ◽

Weiwei He ◽

Hua Gong ◽

Chao Wang ◽

Qian Chen ◽

...

Keyword(s):

Cancer Therapy ◽

Near Infrared ◽

Organic Dye ◽

Highly Effective

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Ultrathin carbon layer coated MoO2 nanoparticles for high-performance near-infrared photothermal cancer therapy

Chemical Communications ◽

10.1039/c5cc02016f ◽

2015 ◽

Vol 51 (49) ◽

pp. 10054-10057 ◽

Cited By ~ 34

Author(s):

Qin Liu ◽

Chunyang Sun ◽

Qun He ◽

Daobin Liu ◽

Adnan Khalil ◽

...

Keyword(s):

Cancer Therapy ◽

High Performance ◽

Near Infrared ◽

Solvothermal Method ◽

Carbon Layer

Uniform MoO2 nanoparticles coated with ultrathin carbon layers, synthesized by a solvothermal method, were demonstrated as a promising NIR photothermal agent by in vitro and in vivo tests.

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Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy

Chemical Communications ◽

10.1039/d0cc00416b ◽

2020 ◽

Vol 56 (25) ◽

pp. 3629-3632 ◽

Cited By ~ 2

Author(s):

Xinwei Tian ◽

Zhao Li ◽

Ning Ding ◽

Jiahang Zhang

Keyword(s):

Cancer Therapy ◽

Real Time ◽

Cancer Chemotherapy ◽

Near Infrared ◽

Self Assembled

A novel near-infrared ratiometric fluorescent theranostic nanoprobe is applied for real-time fluorescence tracking and imaging cancer therapy in vivo and in situ.

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Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽

10.3390/cancers11091286 ◽

2019 ◽

Vol 11 (9) ◽

pp. 1286 ◽

Cited By ~ 6

Author(s):

Lee ◽

Jung ◽

Jo ◽

Yang ◽

Koh ◽

...

Keyword(s):

Cancer Therapy ◽

Laser Irradiation ◽

Near Infrared ◽

Photothermal Effect ◽

Great Promise ◽

Targeted Cancer Therapy ◽

Potential Applications ◽

Photothermal Property ◽

Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

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