scholarly journals Mining for Peaks in LC-HRMS Datasets Using Finnee – A Case Study with Exhaled Breath Condensates from Healthy, Asthmatic, and COPD Patients

ACS Omega ◽  
2020 ◽  
Vol 5 (26) ◽  
pp. 16089-16098
Author(s):  
Guillaume L. Erny ◽  
Ricardo A. Gomes ◽  
Mónica S. F. Santos ◽  
Lúcia Santos ◽  
Nuno Neuparth ◽  
...  
Keyword(s):  
Exhaled Breath ◽  
Copd Patients

Exhaled breath monitoring during home ventilo-therapy in COPD patients by a new distributed tele-medicine system

2019 ◽  
Author(s):  
Antonio Vincenzo Radogna ◽  
Nicola Fiore ◽  
Maria Rosaria Tumolo ◽  
Valerio De Luca ◽  
Lucio T. De Paolis ◽  
...  
Keyword(s):  
Exhaled Breath ◽  
Copd Patients ◽  
Breath Monitoring

Prospective Early Detection of Lung Cancer in COPD Patients by Electronic Nose Analysis of Exhaled Breath

2019 ◽  
Author(s):  
R. de Vries ◽  
J.M. van den Heuvel ◽  
Y.W.F. Dagelet ◽  
E. Dijkers ◽  
T. Fabius ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Electronic Nose ◽  
Exhaled Breath ◽  
Copd Patients

scholarly journals Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label

2018 ◽  
Vol 51 (1) ◽  
pp. 1701817 ◽  
Author(s):  
Rianne de Vries ◽  
Yennece W.F. Dagelet ◽  
Pien Spoor ◽  
Erik Snoey ◽  
Patrick M.C. Jak ◽  
...  
Keyword(s):  
Principal Component ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Dependent Manner ◽  
Cross Sectional ◽  
Exacerbation Rate ◽  
Copd Patients ◽  
Validation Set ◽  
Inflammatory Phenotypes ◽  
Chronic Airway

Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set.This was a multicentre cross-sectional study in which exhaled breath from asthma and COPD patients (n=435; training n=321 and validation n=114) was analysed using eNose technology. Data analysis involved signal processing and statistics based on principal component analysis followed by unsupervised cluster analysis and supervised linear regression.Clustering based on eNose resulted in five significant combined asthma and COPD clusters that differed regarding ethnicity (p=0.01), systemic eosinophilia (p=0.02) and neutrophilia (p=0.03), body mass index (p=0.04), exhaled nitric oxide fraction (p<0.01), atopy (p<0.01) and exacerbation rate (p<0.01). Significant regression models were found for the prediction of eosinophilic (R2=0.581) and neutrophilic (R2=0.409) blood counts based on eNose. Similar clusters and regression results were obtained in the validation set.Phenotyping a combined sample of asthma and COPD patients using eNose provides validated clusters that are not determined by diagnosis, but rather by clinical/inflammatory characteristics. eNose identified systemic neutrophilia and/or eosinophilia in a dose-dependent manner.

scholarly journals Cigarette-related cadmium and environmental pollution exposure are reflected in airway ultrafine particle content

2020 ◽  
Vol 6 (3) ◽  
pp. 00361-2019
Author(s):  
Einat Klein Fireman ◽  
Yochai Adir ◽  
Elizabeth Fireman ◽  
Aharon Kessel
Keyword(s):  
Environmental Pollution ◽  
Ultrafine Particles ◽  
Exhaled Breath Condensate ◽  
Ultrafine Particle ◽  
Exhaled Breath ◽  
Cadmium Content ◽  
Inflammatory Status ◽  
Copd Patients ◽  
High Level

IntroductionParticulate matter (PM) and cigarette-related cadmium exposure increases inflammation and smokers' susceptibility to developing lung diseases. The majority of inhaled metals are attached to the surface of ultrafine particles (UFPs). A low inhaled UFP content in exhaled breath condensate (EBC) reflects a high inflammatory status of airways.MethodsEBC was collected from 58 COPD patients and 40 healthy smokers and nonsmokers. Participants underwent spirometry, diffusion capacity, EBC and blood sampling. Environmental pollution data were collected from monitoring stations. UFPs were measured in EBC and serum, and cadmium content was quantified.ResultsSubjects with low UFP concentrations in EBC (<0.18×108·mL−1) had been exposed to higher long-term PM2.5 levels versus subjects with high UFP concentrations in EBC (>0.18×108·mL−1) (21.9 µg·m−3versus 17.4 µg·m−3, p≤0.001). Long-term PM2.5 exposure levels correlated negatively with UFP concentrations in EBC and positively with UFP concentrations in serum (r=−0.54, p≤0.001 and r=0.23, p=0.04, respectively). Healthy smokers had higher cadmium levels in EBC versus healthy nonsmokers and COPD patients (25.2 ppm versus 23.7 ppm and 23.3 ppm, p=0.02 and p=0.002, respectively). Subjects with low UFP concentrations in EBC also had low cadmium levels in EBC versus subjects with high UFP levels (22.8 ppm versus 24.2 ppm, p=0.004)ConclusionsLow UFP concentration in EBC is an indicator of high-level PM exposure. High cadmium levels in EBC among smokers and the association between cadmium and UFP content in EBC among COPD patients indicate cadmium lung toxicity.

scholarly journals Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Nailya Kubysheva ◽  
Larisa Postnikova ◽  
Svetlana Soodaeva ◽  
Viкtor Novikov ◽  
Tatyana Eliseeva ◽  
...  
Keyword(s):  
Lung Function ◽  
Blood Serum ◽  
Exhaled Breath Condensate ◽  
Diagnostic Methods ◽  
Stable Phase ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Severe Copd

The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied. An unidirectional change in the content of sCD25, sCD38, and sCD8 molecules with increasing severity of COPD was detected. The correlations between the parameters of lung function and sCD8, sCD25, and sHLA-I-CD8 levels in the blood serum and EBC were discovered in patients with severe COPD. The findings suggest a pathogenetic role of the investigated soluble molecules of the COPD development and allow considering the content of sCD8, sCD25, and sHLA-I-CD8 molecules as additional novel systemic and endobronchial markers of the progression of chronic inflammation of this disease.

scholarly journals Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients

2009 ◽  
Vol 10 (1) ◽  
Author(s):  
Rembert Koczulla ◽  
Silvano Dragonieri ◽  
Robert Schot ◽  
Robert Bals ◽  
Stefanie A Gauw ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Healthy Controls ◽  
Copd Patients ◽  
Breath Condensate

The necessity of external validation in exhaled breath research: a case study of sarcoidosis

2017 ◽  
Vol 12 (1) ◽  
pp. 016004 ◽  
Author(s):  
Rianne R R Fijten ◽  
Agnieszka Smolinska ◽  
Marjolein Drent ◽  
Jan W Dallinga ◽  
Remy Mostard ◽  
...  
Keyword(s):  
External Validation ◽  
Exhaled Breath

NMR-based metabolomics of exhaled breath condensate for assessing the effects of inhaled corticosteroids in COPD patients

2017 ◽  
Author(s):  
Paolo Montuschi ◽  
Giuseppe Santini ◽  
Nadia Mores ◽  
Tim Higenbottam ◽  
Alessia Vignoli ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Copd Patients ◽  
Breath Condensate

The impact of acute smoke exposure on selected biomarkers in exhaled breath condensate in COPD patients and healthy smokers

2016 ◽  
Author(s):  
Marta Maskey-Warzechowska ◽  
Patrycja Nejman-Gryz ◽  
Katarzyna Osinka ◽  
Paulina Lis ◽  
Kamila Malesa ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Smoke Exposure ◽  
Exhaled Breath ◽  
Copd Patients ◽  
The Impact ◽  
Breath Condensate

INHALED CORTICOSTEROIDS PREVENT EXHALED BREATH CONDENSATE ACIDIFICATION IN MECHANICALLY VENTILATED COPD PATIENTS

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 209S
Author(s):  
Aliaksandr Y. Skrahin ◽  
Aliaksandr S. Smirnou ◽  
Anatoli D. Tahanovich ◽  
Alena M. Skrahina ◽  
Andrei P. Astrauko
Keyword(s):  
Inhaled Corticosteroids ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Mechanically Ventilated ◽  
Copd Patients ◽  
Breath Condensate
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