scholarly journals Phenylboronic-acid-based Functional Chemical Materials for Fluorescence Imaging and Tumor Therapy

ACS Omega ◽  
2022 ◽  
Author(s):  
Shuo Li ◽  
XinHui Hou ◽  
Yufan Ma ◽  
Zhuo Wang
Keyword(s):  
Fluorescence Imaging ◽  
Phenylboronic Acid ◽  
Tumor Therapy ◽  
Chemical Materials

Co-delivery of chlorin e6 and doxorubicin using PEGylated hollow nanocapsules for ‘all-in-one’ tumor theranostics

Nanomedicine ◽  
2019 ◽  
Vol 14 (17) ◽  
pp. 2273-2292 ◽  
Author(s):  
Qian Li ◽  
Mengmeng Hou ◽  
Junjie Ren ◽  
Shiyu Lu ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Chlorin E6 ◽  
Precipitation Method ◽  
Antitumor Effects ◽  
Cancer Management ◽  
Therapeutic Outcomes ◽  
Poly Ethylene

Aim: Hollow mesoporous copper sulfide nanocapsules conjugated with poly(ethylene glycol) (PEG), doxorubicin and chlorin e6 (HPDC) were synthesized for fluorescence imaging and multimodal tumor therapy. Materials & methods: HPDC were synthesized by encapsulating chlorin e6 and doxorubicin into PEGylated nanocapsules via a simple precipitation method. The photothermal/photodynamic effects, drug release, cellular uptake, imaging capacities and antitumor effects of the HPDCs were evaluated. Results: This smart nanoplatform is stimulus-responsive toward an acidic microenvironment and near infrared laser irradiation. Moreover, fluorescence imaging-guided and combined photothermal/photodynamic/chemotherapies of tumors were promoted under laser activation and led to efficient tumor ablation, as evidenced by exploring animal models in vivo. Conclusion: HPDCs are expected to serve as potent and reliable nanoagents for achieving superior therapeutic outcomes in cancer management.

scholarly journals Lanthanide Europium MOF Nanocomposite as the Theranostic Nanoplatform for Microwave Thermo-Chemotherapy and Fluorescence Imaging

2021 ◽  
Author(s):  
Lirong Zhao ◽  
Wei Zhang ◽  
Qiong Wu ◽  
Changhui Fu ◽  
Xiangling Ren ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Tumor Imaging ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Liver Cancer Cells ◽  
Good Ability ◽  
Metal Organic

Abstract Backgrounds: Microwave sensitization nanoplatform, integrating multiple functional units for improving tumor selectivity, is of great significance for clinical tumor microwave therapy. Lanthanide europium metal organic framework materials (EuMOF) are expected to be a theranostic nanoplatform owing to its specific luminescent properties and microwave sensitization properties. However, it is difficult to be applied to complex biological systems for EuMOF due to its rapid degradation induced by the solvent molecular and ionic environment. In this work, a luminescent EuMOF nanocomposite (EuMOF@ZIF/AP-PEG, named EZAP) was designed, which brought the multifunctional characteristics of microwave sensitization, fluorescence imaging and drug loading. Results Lamellar EuMOF was synthesized by a hydrothermal method. Through the charge adsorption mechanism, the zeolite imidazole framework (ZIF) structure was densely assembled on the surface of EuMOF to realize the protection. Then, through in-situ apatinib drug loading and PEG modification, EZAP nanocomposite was finally obtained. Apatinib (AP) was a kind of chemotherapy drug approved by Food and Drug Administration for clinical use. PEG modification increased long-term circulation of EZAP nanocomposite. The physical and chemical structure and properties of EuMOF@ZIF (EZ) were systematically represented, indicating the successful synthesis of the nanocomposite. The toxic and side effects were negligible at a safe dose. The growth of human liver cancer cells and murine liver cancer cells in vitro was significantly inhibited, and the combined microwave-thermal therapy and chemotherapy in vivo achieved high anti-cancer efficacy. Moreover, EZAP nanocomposite possessed bright red fluorescence, which had good ability for tumor imaging in tumor-bearing mice in vivo. Conclusion Therefore, EZAP nanocomposite showed high microwave sensitization, excellent fluorescence properties and good drug loading capacity, establishing a promising theranostic nanoplatform for tumor therapy and fluorescence imaging. This work proposes a unique strategy to design for the first time a multifunctional nanoplatform with lanthanide metal organic frameworks for tumor treatment and diagnosis in the biological application.

Engineering Glutathione-responsive Near-Infrared Polymeric Prodrug System for Fluorescence Imaging in Tumor Therapy

2021 ◽  
pp. 111966
Author(s):  
Xiaoli Zhang ◽  
Die Jia ◽  
Yuxin Wang ◽  
Feiqiu Wen ◽  
Xingliang Zhang
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Polymeric Prodrug

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

2020 ◽  
pp. 088532822095259
Author(s):  
Ke Ma ◽  
Yongbin Cheng ◽  
Xinran Wei ◽  
Daijun Chen ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Drug Release ◽  
Fluorescence Imaging ◽  
Colloidal Stability ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Chitosan Nanoparticles ◽  
Fluorescence Emission ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
One Pot

In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

Fluorescence imaging for in situ detection of cell surface sialic acid by competitive binding of 3-(dansylamino)phenylboronic acid

2015 ◽  
Vol 894 ◽  
pp. 85-90 ◽  
Author(s):  
Ruocan Qian ◽  
Lin Ding ◽  
Liwen Yan ◽  
Huangxian Ju
Keyword(s):  
Sialic Acid ◽  
Cell Surface ◽  
Fluorescence Imaging ◽  
Phenylboronic Acid ◽  
Competitive Binding ◽  
In Situ Detection

Phenylboronic acid-sugar grafted polymer architecture as a dual stimuli-responsive gene carrier for targeted anti-angiogenic tumor therapy

Biomaterials ◽  
2016 ◽  
Vol 75 ◽  
pp. 102-111 ◽  
Author(s):  
Jinhwan Kim ◽  
Yeong Mi Lee ◽  
Hyunwoo Kim ◽  
Dongsik Park ◽  
Jihoon Kim ◽  
...  
Keyword(s):  
Phenylboronic Acid ◽  
Tumor Therapy ◽  
Gene Carrier ◽  
Stimuli Responsive ◽  
Polymer Architecture ◽  
Grafted Polymer ◽  
Responsive Gene

scholarly journals Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy

2017 ◽  
pp. rbw045 ◽  
Author(s):  
Ling Huang ◽  
Qingfeng Zhang ◽  
Liangliang Dai ◽  
Xinkun Shen ◽  
Weizhen Chen ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Phenylboronic Acid ◽  
Tumor Therapy ◽  
Hollow Silica ◽  
Dual Responsive ◽  
Hollow Silica Nanoparticles

H2O2 self-supplying degradable epitope imprinted polymers for targeted fluorescence imaging and chemodynamic therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Hai-Yan Wang ◽  
Zheng-Chen Su ◽  
Xi-Wen He ◽  
Wen-You Li ◽  
Yukui Zhang
Keyword(s):  
Hydroxyl Radical ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Tumor Therapy ◽  
Imprinted Polymers

Chemodynamic therapy (CDT), being to transform H2O2 into highly toxic hydroxyl radical (•OH) through Fenton or Fenton like reaction to kill cancer cells, had the ability of selective tumor therapy....

Biomimetic magnetofluorescent ferritin nanoclusters for magnetic resonance and fluorescence-dual modal imaging and targeted tumor therapy

2021 ◽  
Author(s):  
Rongguang Song ◽  
Jian Dai Dai ◽  
Miaoliang Ruan ◽  
Wei Xue
Keyword(s):  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Tumor Therapy ◽  
Multiple Imaging

Multiple imaging by combing magnetic resonance (MR) and fluorescence imaging into a single nanosystem displays distinctive merits, which is desirable for precise in vivo imaging. In this work, we proposed...

Sign in / Sign up

Export Citation Format

Share Document