Epidermal Growth Factor-Conjugated Poly(ethylene glycol)-block- Poly(δ-valerolactone) Copolymer Micelles for Targeted Delivery of Chemotherapeutics

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

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Magnetic Epidermal Growth Factor Conjugate for Targeted Delivery to Grafted Tumor in Mouse Model

IEEE Transactions on Magnetics ◽

10.1109/tmag.2012.2223203 ◽

2013 ◽

Vol 49 (1) ◽

pp. 429-435 ◽

Cited By ~ 8

Author(s):

Boris. P. Nikolaev ◽

Yaroslav Yu Marchenko ◽

Liudmila Yu Yakovleva ◽

Tatiana M. Zimina ◽

Alexei V. Soloviev ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Mouse Model ◽

Targeted Delivery ◽

Epidermal Growth

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A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits

Biomaterials ◽

10.1016/j.biomaterials.2015.08.054 ◽

2015 ◽

Vol 72 ◽

pp. 112-124 ◽

Cited By ~ 24

Author(s):

Jacob L. Roam ◽

Ying Yan ◽

Peter K. Nguyen ◽

Ian S. Kinstlinger ◽

Michael K. Leuchter ◽

...

Keyword(s):

Growth Factor ◽

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Stabilization of poly(ethylene glycol)-poly(ε-caprolactone) star block copolymer micelles via aromatic groups for improved drug delivery properties

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2017.12.057 ◽

2018 ◽

Vol 514 ◽

pp. 468-478 ◽

Cited By ~ 16

Author(s):

Sytze Buwalda ◽

Assala Al Samad ◽

Ayman El Jundi ◽

Audrey Bethry ◽

Youssef Bakkour ◽

...

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Star Block Copolymer ◽

Block Copolymer Micelles ◽

Copolymer Micelles ◽

Poly Ethylene

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The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics ◽

10.3390/pharmaceutics12111068 ◽

2020 ◽

Vol 12 (11) ◽

pp. 1068 ◽

Cited By ~ 1

Author(s):

Danijela Zukancic ◽

Estelle J. A. Suys ◽

Emily H. Pilkington ◽

Azizah Algarni ◽

Hareth Al-Wassiti ◽

...

Keyword(s):

Lymph Node ◽

Gene Delivery ◽

Ethylene Glycol ◽

Lymph Nodes ◽

Injection Site ◽

Targeted Delivery ◽

Lipid Nanoparticles ◽

Tween 20 ◽

Poly Ethylene Glycol ◽

Poly Ethylene

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfection at various tissues. Here we report novel lipid nanoparticles (LNPs) that can deliver plasmid DNA (pDNA) to a draining lymph node, thereby significantly enhancing transfection at this target organ, and substantially reducing gene expression at the intramuscular injection site (muscle). In particular, we discovered that LNPs stabilized by 3% Tween 20, a surfactant with a branched poly(ethylene glycol) (PEG) chain linking to a short lipid tail, achieved highly specific transfection at the lymph node. This was in contrast to conventional LNPs stabilized with a linear PEG chain and two saturated lipid tails (PEG-DSPE) that predominately transfected at the injection site (muscle). Interestingly, replacing Tween 20 with Tween 80, which has a longer unsaturated lipid tail, led to a much lower transfection efficiency. Our work demonstrates the importance of PEGylation in selective organ targeting of nanoparticles, provides new insights into the structure–property relationship of LNPs, and offers a novel, simple, and practical PEGylation technology to prepare the next generation of safe and effective vaccines against viruses or tumours.

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