Role of the internal cross-link in oxytocin. Preparation of mercury mercaptide oxytocin derivatives

Biochemistry ◽  
1974 ◽  
Vol 13 (11) ◽  
pp. 2347-2353 ◽  
Author(s):  
Ruth Sperling ◽  
Marian Gorecki
Keyword(s):  
Cross Link

Studies on the Mechanism of Action of Azinomycin B:  Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate

2002 ◽  
Vol 124 (44) ◽  
pp. 13008-13017 ◽  
Author(s):  
Robert S. Coleman ◽  
Ronelito J. Perez ◽  
Christopher H. Burk ◽  
Antonio Navarro
Keyword(s):  
Mechanism Of Action ◽  
Cross Link ◽  
Sequence Selectivity ◽  
Definition Of ◽  
Azinomycin B ◽  
Link Formation

The role of cross-link augmentation on fusion rate and patient satisfaction among patients with traumatic thoracolumbar spinal fracture: A randomized clinical trial

Neurocirugía ◽  
2021 ◽  
Author(s):  
Farhad Mirzaei ◽  
Arad Iranmehr ◽  
Ghaffar Shokouhi ◽  
Masoud Khadivi ◽  
Moslem Shakeri ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Patient Satisfaction ◽  
Randomized Clinical Trial ◽  
Fusion Rate ◽  
Spinal Fracture ◽  
Cross Link

Role of the FAD-dependent polyamine oxidase in the selective formation of N1,N8-bis(γ- glutamyl)spermidine protein cross-links1

2007 ◽  
Vol 35 (2) ◽  
pp. 396-400 ◽  
Author(s):  
A. Lentini ◽  
P. Mattioli ◽  
B. Provenzano ◽  
A. Abbruzzese ◽  
M. Caraglia ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Polyamine Oxidase ◽  
Polyamine Metabolism ◽  
Suitable Model ◽  
Cross Link ◽  
Cellular Mechanisms ◽  
Preferential Formation ◽  
Cross Links ◽  
Selective Formation

Protein-bound γ-glutamylpolyamines have highlighted a new pathway in polyamine metabolism. Human foreskin keratinocytes offer a suitable model for this study. Indeed, they develop polymerized envelopes, as they differentiate, rich in ϵ-(γ-glutamyl)lysine and N1,N8-bis(γ-glutamyl)spermidine cross-links. We have found that the selective oxidation of N1-(γ-glutamyl)spermidine and N-(γ-glutamyl)spermine by FAD-dependent polyamine oxidase (PAO) may be one of the cellular mechanisms regulating the preferential formation of a sterically defined bis(γ-glutamyl)spermidine cross-link. The significance of this finding is unknown, but it suggests that the target of this PAO-modulation is to achieve the biochemical prerequisite for production of a normal epidermal stratum corneum.

scholarly journals THE ROLE OF POTASSIUM AND CALSIUM IN IMPROVING THE QUALITY AND SHELF LIFE OF TOMATO (Lycopersicum esculentum var. servo)

el–Hayah ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 84-93
Author(s):  
Puguh Catur Wicaksana ◽  
Ketut Anom Wijaya ◽  
Sigit Soeparjono
Keyword(s):  
Cell Wall ◽  
Shelf Life ◽  
Cell Wall Regeneration ◽  
Cross Link ◽  
Tomato Production ◽  
High Productivity ◽  
Long Duration ◽  
High Respiration Rate ◽  
Quality And Shelf Life

Tomato has the characteristics natural to damage. Damage fruits are caused by destitute of fruit quality and sensory attributes. The loss of tomato production on harvest in developing countries reached 50% due to the long duration of tomato distribution. Servo varieties of tomatoes are in demand by farmers because of their genetic advantages, high productivity, and abundant fruit weights. The shortage of servo varieties of tomatoes is the short shelf life of fruit, which is seven days after harvest. Short shelf life is influenced by fruit thickness and fruit hardness. In improving the quality and shelf life of tomatoes, potassium (K) nutrition plays a role in photosynthetic translocation, strengthens the cell wall, and involved in the lignification process of sclerenchyma tissue. Tomatoes, as climacteric fruits have a high respiration rate influenced by ethylene. Ethylene production can be inhibited by calcium chloride (CaCl2) application by strengthening the cell wall mechanism, cross-link with pectin, and increase the cell wall regeneration can change the texture of the fruit become harder, and it reduces sensitivity to physiological damage. Based on the treatment of this research, the quality and shelf life of servo varieties of tomato is increased.

scholarly journals Thyrotropin cross-links to the thyrotropin receptor through both the α and β subunits

1986 ◽  
Vol 235 (3) ◽  
pp. 879-882 ◽  
Author(s):  
P R Buckland ◽  
C R Rickards ◽  
R D Howells ◽  
B R Smith
Keyword(s):  
Tsh Receptor ◽  
Alpha Subunit ◽  
Receptor Interaction ◽  
Cross Linking ◽  
Thyrotropin Receptor ◽  
Cross Link ◽  
Receptor Binding Site ◽  
Form Part ◽  
Cross Links

We have recently shown that the beta subunit of thyrotropin (TSH) can be cross-linked to the TSH receptor [Buckland, Strickland, Pierce & Rees Smith (1985) Endocrinology (Baltimore) 116, 2122-2124; Buckland, Strickland & Rees Smith (1985) Biochem. Soc. Trans. 13, 942-943]. We failed, however, to cross-link the alpha subunit to the receptor, leaving the role of this subunit in the TSH-TSH-receptor interaction uncertain. We now report the successful cross-linking of the TSH alpha subunit to the receptor by the use of two different cross-linking reagents. Our studies suggest therefore that both subunits of TSH form part of the hormone's receptor-binding site.

scholarly journals The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo

1984 ◽  
Vol 221 (3) ◽  
pp. 837-843 ◽  
Author(s):  
M J Carrington ◽  
T A Bird ◽  
C I Levene
Keyword(s):  
Pyridoxal Phosphate ◽  
Isonicotinic Acid ◽  
Lysyl Oxidase ◽  
Acid Hydrazide ◽  
Chick Embryos ◽  
Cross Link ◽  
Irreversible Inhibitor ◽  
Link Formation

Isonicotinic acid hydrazide (isoniazid) causes a large increase in the salt-solubility of collagen when injected into chick embryos; this change is accompanied by the inactivation of lysyl oxidase (EC 1.4.3.13), the enzyme responsible for initiating cross-link formation in collagen and elastin. In addition, isoniazid markedly decreases the liver content of pyridoxal phosphate. The depletion of pyridoxal phosphate takes approx. 6 h, whereas the inhibition of lysyl oxidase and the increase in collagen solubility occur more slowly. A reversal of these effects of isoniazid can be produced by the subsequent injection of a stoichiometric amount of pyridoxal, supporting the role of pyridoxal as a cofactor for lysyl oxidase. Treatment of chick embryos with beta-aminopropionitrile, an irreversible inhibitor of lysyl oxidase, causes an inhibition of the enzyme, which begins to recover within 24 h but which is not affected by the administration of pyridoxal; with isoniazid inhibition, however, lysyl oxidase activity does not show any sign of recovery by 48 h. It is proposed that isoniazid may cause the inhibition of lysyl oxidase by competing for its obligatory cofactor, pyridoxal phosphate. The potential clinical implications in the therapeutic control of fibrosis are briefly discussed.

Structural studies on cross-linked peptides containing lysinonorleucine from elastin of porcine aorta

1977 ◽  
Vol 55 (3) ◽  
pp. 244-248
Author(s):  
Maonique Davril ◽  
Kia-Ki Han
Keyword(s):  
Acid Hydrolysis ◽  
Structural Studies ◽  
Cross Link ◽  
Structural Investigations ◽  
Partial Acid Hydrolysis

Three lysinonorleucine peptides were isolated from mature porcine aorta elastin after enzymic digestions and partial acid hydrolysis. The structural investigations which were performed suggest that different regions containing lysinonorleucine may exist. The role of this cross-link in mature elastin is discussed.

Effects of fibrin on the enhanced activation of plasminogen by urokinase and tissue plasminogen activator: Role of cross-link

1986 ◽  
Vol 41 (5) ◽  
pp. 605-613 ◽  
Author(s):  
Akikazu Takada ◽  
Yoichi Watahiki ◽  
Yumiko Takada
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Cross Link ◽  
Tissue Plasminogen

scholarly journals The Role of the Cross-link His-Tyr in the Functional Properties of the Binuclear Center in CytochromecOxidase

2002 ◽  
Vol 277 (16) ◽  
pp. 13563-13568 ◽  
Author(s):  
Eftychia Pinakoulaki ◽  
Ute Pfitzner ◽  
Bernd Ludwig ◽  
Constantinos Varotsis
Keyword(s):  
Functional Properties ◽  
Cross Link ◽  
Binuclear Center ◽  
The Cross

The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro

2006 ◽  
Vol 13 (8) ◽  
pp. 729-733 ◽  
Author(s):  
Lubos Cipak ◽  
Norifumi Watanabe ◽  
Tadayoshi Bessho
Keyword(s):  
Cross Link
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