scholarly journals Interaction of C1q with IgG1, C-reactive Protein and Pentraxin 3:  Mutational Studies Using Recombinant Globular Head Modules of Human C1q A, B, and C Chains†

Biochemistry ◽  
2006 ◽  
Vol 45 (13) ◽  
pp. 4093-4104 ◽  
Author(s):  
Lubka T. Roumenina ◽  
Marieta M. Ruseva ◽  
Alexandra Zlatarova ◽  
Rohit Ghai ◽  
Martin Kolev ◽  
...  
Keyword(s):  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Globular Head

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

2013 ◽  
Author(s):  
Janusz Szkodzinski ◽  
Bartosz Hudzik ◽  
Aleksander Danikiewicz ◽  
Anna Pietka-Rzycka ◽  
Andrzej Lekston ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Disease Severity ◽  
Artery Disease ◽  
Sensitive Marker

scholarly journals Pentraxin 3: A Novel Biomarker for Inflammatory Cardiovascular Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kenji Inoue ◽  
Tatsuhiko Kodama ◽  
Hiroyuki Daida
Keyword(s):  
Gene Expression ◽  
Cardiovascular Disease ◽  
Pentraxin 3 ◽  
Human Endothelial Cells ◽  
C Reactive Protein ◽  
Physiological Concentration ◽  
Reactive Protein ◽  
Atherosclerotic Lesions ◽  
Human Genes

Numerous studies have recently examined the role of pentraxin 3 (PTX3) in clinical situations. The pentraxin family includes C-reactive protein (CRP); however, unlike CRP, PTX3 is expressed predominantly in atherosclerotic lesions that involve macrophages, neutrophils, dendritic cells, or smooth muscle cells. Interestingly, PTX3 gene expression in human endothelial cells is suppressed to a greater extent by pitavastatin than the expression of 6,000 other human genes that have been examined, suggesting that PTX3 may be a novel biomarker for inflammatory cardiovascular disease. The expression and involvement of PTX3 in cardiovascular diseases are discussed in this paper, along with the characteristics of PTX3 that make it a suitable biomarker; namely, that the physiological concentration is known and it is independent of other risk factors. The results discussed in this paper suggest that further investigations into the potential novel use of PTX3 as a biomarker for inflammatory cardiovascular disease should be undertaken.

scholarly journals Calorie Restriction Modulates Inactivity-Induced Changes in the Inflammatory Markers C-Reactive Protein and Pentraxin-3

2008 ◽  
Vol 93 (8) ◽  
pp. 3226-3229 ◽  
Author(s):  
Alessandra Bosutti ◽  
Grazia Malaponte ◽  
Michela Zanetti ◽  
Pietro Castellino ◽  
Martina Heer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Inflammatory Response ◽  
Calorie Restriction ◽  
Inflammatory Markers ◽  
Bed Rest ◽  
Energy Restriction ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Context: Energy balance and physical activity potentially influence systemic inflammation. Objective: Our objective was to test the hypothesis that moderate energy restriction may prevent activation of inactivity-induced inflammatory response. Design: Participants were studied four times at the end of 14-d periods of experimental bed rest or controlled ambulation, after receiving eucaloric or hypocaloric diets. Setting: The study was conducted at the clinical research center of the German Space Agency. Subjects: Nine healthy young volunteers participated. Interventions: Energy intake was calibrated to physical activity and decreased by about 20% in hypocaloric conditions. Main Outcome Measures: Changes in body fat by dual-energy x-ray absorptiometry as well as plasma inflammatory markers and cytokine mRNA levels in blood cells were measured. Results: Fat mass did not change significantly in eucaloric conditions and decreased in hypocaloric periods (−1.0 ± 0.3 and −1.0 ± 0.3 kg in ambulatory and bed rest, respectively). Bed rest in eucaloric conditions increased plasma C-reactive protein (CRP) (+143 ± 53%) and both the ratios between plasma IL-6 and IL-10 (4±1 times) and white blood cell IL-6 and IL-10 mRNAs (5 ± 1 times). Energy restriction prevented bed-rest-mediated increases in CRP and the IL-6 to IL-10 ratio. Bed rest increased (P = 0.03) long pentraxin-3 (PTX3) plasma concentration, without significant activity-by-diet interaction. In all conditions (n = 36), CRP and PTX3 were inversely correlated (r = −0.61; P < 0.001). Changes in fat mass, leptin, and IL-6 directly correlated with CRP and inversely correlated with PTX3. IL-10 inversely correlated with CRP and directly correlated with PTX3 (r = 0.52; P < 0.01). Conclusions: Calorie restriction prevents the inflammatory response induced by 14 d of bed rest. We suggest an inverse regulation of CRP and PTX3 in response to changes in energy balance.

scholarly journals Different Distribution of Pentraxin 3 and C-Reactive Protein in Coronary Atherosclerotic Plaques

2012 ◽  
Vol 19 (9) ◽  
pp. 837-845 ◽  
Author(s):  
Yunosuke Matsuura ◽  
Kinta Hatakeyama ◽  
Takuroh Imamura ◽  
Toshihiro Tsuruda ◽  
Yoshisato Shibata ◽  
...  
Keyword(s):  
Atherosclerotic Plaques ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Plasma pentraxin 3 may be a better marker of peripheral artery disease in hemodialysis patients than C-reactive protein

2013 ◽  
Vol 18 (2) ◽  
pp. 85-91 ◽  
Author(s):  
Yijun Zhou ◽  
Zhaohui Ni ◽  
Jiwei Zhang ◽  
Weiming Zhang ◽  
Qingwei Wu ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Hemodialysis Patients ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Peripheral Artery ◽  
Reactive Protein ◽  
Artery Disease

scholarly journals The effect of different anesthesia applications on serum Pentraxin-3 levels: a randomized prospective study

2021 ◽  
Vol 8 (9) ◽  
pp. 520-525
Author(s):  
Hatice Betul Altinisik ◽  
Fatma Beyazit ◽  
Hakan Turkon
Keyword(s):  
Treatment Success ◽  
White Blood Cells ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Factors Affecting ◽  
Reactive Protein ◽  
Preoperative Serum ◽  
Inadequate Information ◽  
Significant Change ◽  
Monitoring Treatment

Objective: Pentraxin-3 (PTX3) is a biomarker shown to correlate with the severity of infections. It is a good indicator of mortality and is useful in monitoring treatment success. However, there is inadequate information about the factors affecting PTX3 levels. This study aimed to investigate the effects of different anaesthesia types on serum PTX3 levels. Materials/Patients and Methods: Serum PTX3 levels were obtained from patients who were under general anaesthesia (GA) and spinal anaesthesia (SA) for a caesarean section (C-section). Blood Samples were collected preoperatively at 6 h and 24 h postoperatively. Biomarkers such as C-reactive protein, white blood cells, neutrophils and lymphocytes were also assessed as biomarkers. Results: No difference was found in the preoperative serum PTX3 levels among the participants (p > 0.05). A significant increase was observed when the preoperative PTX3 levels (0.16 ng/mL) were compared with the postoperative levels at 6 h (0.25 ng/mL) and 24 h (0.54 ng/mL) in the GA group. No significant change was found in the PTX3 levels at 0–6–24 h measurements in the SA group. Nevertheless, the GA group was found to be significantly higher than the SA group at 6 h and 24 h postoperatively (p < 0.05). Additionally, No correlation was observed between PTX3 levels and other biomarkers. Conclusions: This study showed that when coupled with C-section, GA increased the PTX3 levels postoperatively compared with the PTX3 levels during the preoperative period. No significant change was observed with SA. The PTX-3 levels should be considered to increase in association with GA in suspected infectious and inflammatory cases. Therefore, regional anaesthesia should be preferred.

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