pH-Sensitive Docetaxel-Loaded d-α-Tocopheryl Polyethylene Glycol Succinate–Poly(β-amino ester) Copolymer Nanoparticles for Overcoming Multidrug Resistance

2013 ◽  
Vol 14 (8) ◽  
pp. 2636-2646 ◽  
Author(s):  
Shuang Zhao ◽  
Songwei Tan ◽  
Yuanyuan Guo ◽  
Jing Huang ◽  
Min Chu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Polyethylene Glycol ◽  
Ph Sensitive ◽  
Glycol Succinate ◽  
Amino Ester

Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer

Biomaterials ◽  
2014 ◽  
Vol 35 (23) ◽  
pp. 6047-6059 ◽  
Author(s):  
Shan Tang ◽  
Qi Yin ◽  
Zhiwen Zhang ◽  
Wangwen Gu ◽  
Lingli Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Ph Sensitive ◽  
Amino Ester

d-α-Tocopherol Polyethylene Glycol Succinate-Based Redox-Sensitive Paclitaxel Prodrug for Overcoming Multidrug Resistance in Cancer Cells

2014 ◽  
Vol 11 (9) ◽  
pp. 3196-3209 ◽  
Author(s):  
Yuling Bao ◽  
Yuanyuan Guo ◽  
Xiangting Zhuang ◽  
Dan Li ◽  
Bolin Cheng ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Polyethylene Glycol ◽  
Cancer Cells ◽  
Glycol Succinate

scholarly journals Comparison of α-Tocopherol, α-Tocopherol Acetate, and α-Tocopheryl Polyethylene Glycol Succinate 1000 Absorption by Caco-2 TC7 Intestinal Cells

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 129
Author(s):  
Charlotte Cuerq ◽  
Claire Bordat ◽  
Charlotte Halimi ◽  
Emilie Blond ◽  
Marion Nowicki ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
High Performance ◽  
Lipid Extraction ◽  
Free Form ◽  
Glycol Succinate ◽  
Tocopherol Acetate ◽  
Apical Side ◽  
Basolateral Side ◽  
Human Enterocyte ◽  
First Time

(1) Background: vitamin E is often supplemented in the form of tocopherol acetate, but it has poor bioavailability and can fail to correct blood tocopherol concentrations in some patients with severe cholestasis. In this context, α-tocopheryl polyethylene glycol succinate 1000 (TPGS) has been of value, but very little is known about the mechanisms of its absorption. The aim of our work was to evaluate the mechanisms of absorption/secretion of TPGS compared to tocopherol acetate (TAC) and α-tocopherol by human enterocyte-like Caco-2 TC7 cells. (2) Methods: two weeks post-confluence Caco-2 cells were incubated with tocopherol- or TAC- or TPGS-rich mixed micelles up to 24 h and, following lipid extraction, TAC and tocopherol amounts were measured by high performance liquid chromatography (HPLC) in apical, cellular, and basolateral compartments. (3) Results: at equivalent concentrations of tocopherol in the apical side, the amounts of tocopherol secreted at the basolateral pole of Caco-2 cells are (i) significantly greater when the tocopherol is in the free form in the micelles; (ii) intermediate when it is in the TAC form in the micelles (p < 0.001); and (iii) significantly lower with the TPGS form (p < 0.0001). Interestingly, our results show, for the first time, that Caco-2 cells secrete one or more esterified forms of the vitamin contained in TPGS at the basolateral side.

RGD-decorated redox-responsived-α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug delivery

2016 ◽  
Vol 4 (13) ◽  
pp. 2338-2350 ◽  
Author(s):  
Yuanyuan Guo ◽  
Boning Niu ◽  
Qingle Song ◽  
Yongdan Zhao ◽  
Yuling Bao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Targeted Drug Delivery ◽  
Glycol Succinate ◽  
Targeted Drug

A novel kind of copolymer, TPGS-SS-PLA, was successfully synthesized and applied in targeted drug delivery.

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