scholarly journals Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase

2012 ◽  
Vol 134 (43) ◽  
pp. 17900-17903 ◽  
Author(s):  
Jaclyn M. Winter ◽  
Michio Sato ◽  
Satoru Sugimoto ◽  
Grace Chiou ◽  
Neil K. Garg ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Polyketide Synthase ◽  
Chaetomium Globosum ◽  
Identification And Characterization ◽  
Dual Functions

scholarly journals Identification and Characterization of a Fimbrial Gene Cluster of Edwardsiella tarda Expressing Mannose-resistant Hemagglutination

2004 ◽  
Vol 39 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Takamitsu Sakai ◽  
Kinya Kanai ◽  
Kiyoshi Osatomi ◽  
Kazuma Yoshikoshi
Keyword(s):  
Gene Cluster ◽  
Edwardsiella Tarda ◽  
Identification And Characterization

Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius

2014 ◽  
Vol 179 ◽  
pp. 10-17 ◽  
Author(s):  
Antonia Gallo ◽  
Benjamin P. Knox ◽  
Kenneth S. Bruno ◽  
Michele Solfrizzo ◽  
Scott E. Baker ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Polyketide Synthase ◽  
Aspergillus Carbonarius ◽  
Identification And Characterization

Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

2019 ◽  
Vol 17 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Taro Shiraishi ◽  
Makoto Nishiyama ◽  
Tomohisa Kuzuyama
Keyword(s):  
Gene Cluster ◽  
In Silico ◽  
Biosynthetic Pathway ◽  
Gene Deletion ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization ◽  
Insight Into

The biosynthetic pathway of the uridine-derived nucleoside antibiotic A-94964 was proposed via in silico analysis coupled with gene deletion experiments.

Identification and Characterization of the Althiomycin Biosynthetic Gene Cluster in Myxococcus xanthus DK897

ChemBioChem ◽  
2011 ◽  
Vol 12 (9) ◽  
pp. 1411-1416 ◽  
Author(s):  
Niña Socorro Cortina ◽  
Ole Revermann ◽  
Daniel Krug ◽  
Rolf Müller
Keyword(s):  
Gene Cluster ◽  
Myxococcus Xanthus ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization

scholarly journals Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans

2008 ◽  
Vol 74 (24) ◽  
pp. 7607-7612 ◽  
Author(s):  
Edyta Szewczyk ◽  
Yi-Ming Chiang ◽  
C. Elizabeth Oakley ◽  
Ashley D. Davidson ◽  
Clay C. C. Wang ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Polyketide Synthase ◽  
Gene Clusters ◽  
Laboratory Culture ◽  
Culture Conditions ◽  
Type I ◽  
Genes Encoding ◽  
Identification And Characterization ◽  
Normal Laboratory

ABSTRACT The sequencing of Aspergillus genomes has revealed that the products of a large number of secondary metabolism pathways have not yet been identified. This is probably because many secondary metabolite gene clusters are not expressed under normal laboratory culture conditions. It is, therefore, important to discover conditions or regulatory factors that can induce the expression of these genes. We report that the deletion of sumO, the gene that encodes the small ubiquitin-like protein SUMO in A. nidulans, caused a dramatic increase in the production of the secondary metabolite asperthecin and a decrease in the synthesis of austinol/dehydroaustinol and sterigmatocystin. The overproduction of asperthecin in the sumO deletion mutant has allowed us, through a series of targeted deletions, to identify the genes required for asperthecin synthesis. The asperthecin biosynthesis genes are clustered and include genes encoding an iterative type I polyketide synthase, a hydrolase, and a monooxygenase. The identification of these genes allows us to propose a biosynthetic pathway for asperthecin.

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