scholarly journals Photoisomerization of Linear and Stacked Isomers of a Charged Styryl Dye: A Tandem Ion Mobility Study

2021 ◽  
Author(s):  
Eduardo Carrascosa ◽  
James N. Bull ◽  
Emilio Martínez-Núñez ◽  
Michael S. Scholz ◽  
Jack T. Buntine ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Styryl Dye ◽  
Mobility Study

scholarly journals Di-Tyrosine Cross-Link Decreases the Collisional Cross-Section of Aβ Peptide Dimers and Trimers in the Gas Phase: An Ion Mobility Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100200 ◽  
Author(s):  
Ewa Sitkiewicz ◽  
Jacek Olędzki ◽  
Jarosław Poznański ◽  
Michał Dadlez
Keyword(s):  
Gas Phase ◽  
Cross Section ◽  
Ion Mobility ◽  
Aβ Peptide ◽  
Cross Link ◽  
Collisional Cross Section ◽  
Mobility Study

scholarly journals Structure of the Pb2+–deprotonated dGMP complex in the gas phase: a combined MS-MS/IRMPD spectroscopy/ion mobility study

2014 ◽  
Vol 16 (27) ◽  
pp. 14127 ◽  
Author(s):  
Jean-Yves Salpin ◽  
Luke MacAleese ◽  
Fabien Chirot ◽  
Philippe Dugourd
Keyword(s):  
Gas Phase ◽  
Ion Mobility ◽  
Irmpd Spectroscopy ◽  
Mobility Study

scholarly journals Effects of Detergent on α-Synuclein Structure: A Native MS-Ion Mobility Study

2020 ◽  
Vol 21 (21) ◽  
pp. 7884
Author(s):  
Rani Moons ◽  
Renate van der Wekken-de Bruijne ◽  
Stuart Maudsley ◽  
Filip Lemière ◽  
Anne-Marie Lambeir ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Ion Mobility ◽  
Intrinsically Disordered Protein ◽  
Detergent Concentration ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Native Ms ◽  
Different Types ◽  
Membrane Models ◽  
Mobility Study

The intrinsically disordered protein α-synuclein plays a major role in Parkinson’s disease. The protein can oligomerize resulting in the formation of various aggregated species in neuronal cells, leading to neurodegeneration. The interaction of α-synuclein with biological cell membranes plays an important role for specific functions of α-synuclein monomers, e.g., in neurotransmitter release. Using different types of detergents to mimic lipid molecules present in biological membranes, including the presence of Ca2+ ions as an important structural factor, we aimed to gain an understanding of how α-synuclein interacts with membrane models and how this affects the protein conformation and potential oligomerization. We investigated detergent binding stoichiometry, affinity and conformational changes of α-synuclein taking detergent concentration, different detergent structures and charges into account. With native nano-electrospray ionization ion mobility-mass spectrometry, we were able to detect unique conformational patterns resulting from binding of specific detergents to α-synuclein. Our data demonstrate that α-synuclein monomers can interact with detergent molecules irrespective of their charge, that protein-micelle interactions occur and that micelle properties are an important factor.

scholarly journals How Spherical Are Gaseous Low Charged Dendrimer Ions: A Molecular Dynamics/Ion Mobility Study?

2020 ◽  
Vol 31 (8) ◽  
pp. 1673-1683
Author(s):  
Fabrice Saintmont ◽  
Julien De Winter ◽  
Fabien Chirot ◽  
Emilie Halin ◽  
Philippe Dugourd ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ion Mobility ◽  
Mobility Study

Mass spectrometry and ion mobility study of poly(ethylene glycol)‐based polyurethane oligomers

2020 ◽  
Vol 34 (S2) ◽  
Author(s):  
Rachel A. Harris ◽  
Jaqueline A. Picache ◽  
Ian D. Tomlinson ◽  
Emanuel Zlibut ◽  
Berkley M. Ellis ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ethylene Glycol ◽  
Ion Mobility ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Mobility Study

scholarly journals Photo and Collision Induced Isomerization of a Cyclic Retinal Derivative: An Ion Mobility Study

2016 ◽  
Vol 27 (9) ◽  
pp. 1483-1490 ◽  
Author(s):  
Neville J. A. Coughlan ◽  
Michael S. Scholz ◽  
Christopher S. Hansen ◽  
Adam J. Trevitt ◽  
Brian D. Adamson ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Mobility Study

scholarly journals Dividing To Unveil Protein Microheterogeneities: Traveling Wave Ion Mobility Study

2011 ◽  
Vol 83 (19) ◽  
pp. 7306-7315 ◽  
Author(s):  
F. Halgand ◽  
Johnny Habchi ◽  
Laetitia Cravello ◽  
Marlène Martinho ◽  
Bruno Guigliarelli ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Traveling Wave ◽  
Traveling Wave Ion Mobility ◽  
Mobility Study
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