Triterpene Alcohol and Sterol Ferulates from Rice Bran and Their Anti-inflammatory Effects

2000 ◽  
Vol 48 (6) ◽  
pp. 2313-2319 ◽  
Author(s):  
Toshihiro Akihisa ◽  
Ken Yasukawa ◽  
Miho Yamaura ◽  
Motohiko Ukiya ◽  
Yumiko Kimura ◽  
...  
Keyword(s):  
Rice Bran ◽  
Triterpene Alcohol ◽  
Anti Inflammatory

Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza SativaL.) Protein Hydrolysates on Raw 264.7 Macrophage Cells

2016 ◽  
Vol 40 (6) ◽  
pp. 731-740 ◽  
Author(s):  
Tanatorn Saisavoey ◽  
Papassara Sangtanoo ◽  
Onrapak Reamtong ◽  
Aphichart Karnchanatat
Keyword(s):  
Rice Bran ◽  
Protein Hydrolysates ◽  
Raw 264.7 ◽  
Defatted Rice Bran ◽  
Macrophage Cells ◽  
Raw 264.7 Macrophage ◽  
Raw 264.7 Macrophage Cells ◽  
Anti Inflammatory

Characterization of Triterpene Alcohol and Sterol Ferulates in Rice Bran Using LC-MS/MS

2003 ◽  
Vol 51 (11) ◽  
pp. 3260-3267 ◽  
Author(s):  
Nianbai Fang ◽  
Shanggong Yu ◽  
Thomas M. Badger
Keyword(s):  
Rice Bran ◽  
Triterpene Alcohol

In vitro anti-inflammatory and skin protective properties of extract comprising ceramides from de-oiled rice bran

2017 ◽  
Vol 41 (3) ◽  
pp. e12353 ◽  
Author(s):  
Manas R. Sahoo ◽  
Sandeep R. Varma ◽  
Neeraj K. Patel ◽  
Thiyagarajan O. Sivaprakasam ◽  
Abheepsa Mishra ◽  
...  
Keyword(s):  
Rice Bran ◽  
Protective Properties ◽  
Anti Inflammatory

scholarly journals Enzymatic hydrolysis on protein and β-glucan content of Sang-yod rice bran hydrolysates and their anti-inflammatory activity on RAW 264.7 cells

2017 ◽  
Vol 7 (12) ◽  
pp. 958 ◽  
Author(s):  
Natcha Phantuwong ◽  
Chakree Thongraung ◽  
Chutha Takahashi Yupanqui
Keyword(s):  
Enzymatic Hydrolysis ◽  
Rice Bran ◽  
Enzyme Concentration ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Macrophage Cell ◽  
Hydrolysis Time ◽  
Hydrolysis Process ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

Background: Research focusing on the improvement of the utilization of rice bran is increasing due to its nutritional properties. Several biological activities of rice bran hydrolysates and its constituents have been reported. Sang-yod rice, a local rice variety in Southern of Thailand, is a pigmented rice. Furthermore, its bran has high nutritive value and health beneficial components. Accordingly, there is growing interest in transforming this by-product into a functional food ingredient.Objective: To investigate the effect of enzymatic hydrolysis processes on the digestion of protein and β-glucan and evaluate anti-proinflammatory properties of selected hydrolysates on RAW 264.7 macrophage cells.Method: Sang-yod rice bran hydrolysates were obtained using a single or co-enzymatic hydrolysis process and sequential hydrolysis process using amyloglucosidase and protease G6. Effects of enzyme concentration (3-5% v/w) and hydrolysis duration (30, 60, and 120 min) on soluble protein and β-glucan contents of obtained rice bran hydrolysates were evaluated. The selected rice bran hydrolysates were evaluated for their cell viability and inhibition against NO and pro-inflammatory cytokines generation on RAW 264.7 mouse macrophage cell lines.  Results: Protein content (0.59-3.37 %) of the rice bran hydrolysates (RBHs) was increased by increasing of enzyme concentration (3-5% v/w) and hydrolysis time (60-120 min). However, the β-glucan content (0.88-4.63%) of RBHs decreased with the increase of those parameters. The RBHs derived by the sequential process using 5% v/w enzyme concentration and 60 min hydrolysis time gave high protein (3.23%) and high β-glucan (4.02%) contents. The hydrolysates with high amount of protein and/or β-glucan contents demonstrated no cytotoxicity against RAW 264.7 cells at concentration range of 100-2,000 μg/ml. Additionally, they demonstrated NO inhibition and pro-inflammatory inhibition ranges of 49.09-71.63% and 9.37-71.96% respectively. Generation of TNF-α, IL-6, and IL-1β cytokines was inhibited differently by the selected RBHs. Conclusion: Pre-digestion of Sang-yod rice bran with amyloglucosidase followed with co-hydrolysis of amyloglucosidase and protease G6 of the sequential hydrolysis process was the most effective process to release β-glucan and protein from of rice bran. The hydrolysate obtained from the process using enzyme concentration at 5%v/w and 60 min hydrolysis duration of each stage had the highest soluble β-glucan and protein content. Moreover, the process provided the hydrolysates with potential anti-inflammatory properties on nitric oxide inhibition and pro-inflammatory cytokines inhibition on RAW 264.7 macrophage cell line. Keywords: Sang-yod rice, Rice bran hydrolysate, β-glucan, Enzymatic hydrolysis, Anti-inflammatory activity 

scholarly journals The Potential of Fractionated Rice Bran Protein Hydrolysates as Antioxidative and Anti-Inflammatory Agents

2020 ◽  
Vol 66 (Supplement) ◽  
pp. S349-S355
Author(s):  
Wasaporn CHANPUT ◽  
Richard LAWYER
Keyword(s):  
Rice Bran ◽  
Protein Hydrolysates ◽  
Rice Bran Protein ◽  
Anti Inflammatory

scholarly journals Anti‐inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice

2020 ◽  
Author(s):  
Lin Umeyama ◽  
Shiori Kasahara ◽  
Misa Sugawara ◽  
Satoru Yokoyama ◽  
Ikuo Saiki ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Rice Bran ◽  
Brown Rice ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takeshi Kamiya ◽  
Michiko Shikano ◽  
Mamoru Tanaka ◽  
Keiji Ozeki ◽  
Masahide Ebi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Placebo Group ◽  
Rice Bran ◽  
Mixed Type ◽  
Group Versus ◽  
Controlled Study ◽  
Therapeutic Effects ◽  
Low Grade ◽  
Anti Inflammatory ◽  
Irritable Bowel

Background. Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one of the mechanisms involved in symptom generation in patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan compound derived from rice bran, has been reported to have several biological actions such as anti-inflammatory and immune modulatory effects. So we investigated the therapeutic effects of Biobran in patients with IBS.Method. Forty patients with diarrhea predominant or mixed type IBS were randomly assigned to either a Biobran group for treatment with Biobran or a placebo group. Therapeutic efficacy and IBS symptoms were assessed subjectively by the patients after 4 weeks of administration.Results. The global assessment was effective in 63.2% of the Biobran group and in 30% of the placebo group (P<0.05, Biobran group versus placebo group). Biobran group showed a significant decrease in the score of diarrhea and constipation and in CRP value. However, no significant changes were observed in the placebo group.Conclusion. The administration of Biobran improved IBS symptoms. It is likely that anti-inflammatory and/or immune modulatory effects of Biobran might be useful in IBS patients.

scholarly journals Anti-oxidant and anti-inflammatory effects of rice bran and green tea fermentation mixture on lipopolysaccharideinduced RAW 264.7 macrophages

2018 ◽  
Vol 16 (12) ◽  
pp. 2943 ◽  
Author(s):  
Yun-Hee Rhee ◽  
Chun Hee Rhee ◽  
Phil-Sang Chung ◽  
Jin-Chul Ahn
Keyword(s):  
Green Tea ◽  
Rice Bran ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Anti Oxidant ◽  
Anti Inflammatory

scholarly journals Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 359
Author(s):  
Hyejeong Park ◽  
Seungmin Yu ◽  
Wooki Kim
Keyword(s):  
Adipose Tissue ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Low Grade ◽  
Obese Mice ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Macrophages are involved in all inflammatory processes from killing pathogens to repairing damaged tissue. In the obese state, macrophages infiltrate into enlarged adipose tissue and polarize into pro-inflammatory M1 macrophages, resulting in chronic low-grade inflammation due to the secretion of inflammatory mediators. Rice bran oil (RBO) is an edible oil containing tocopherols, tocotrienols, and γ-oryzanol. Previous research in normal diet-fed mice suggested that RBO mitigates inflammatory responses by modulating mitochondrial respiration of macrophages. Therefore, we investigated if RBO had an anti-inflammatory effect in diet-induced obese mice by assessing the expression of inflammatory markers in epididymal white adipose tissue (eWAT) and polarization of bone marrow-derived macrophages (BMDMs). Rice bran oil exerted a local anti-inflammatory effect in white adipose tissue by suppressing the production of inflammatory mediators and upregulating transcription of anti-inflammatory genes. Rice bran oil also promoted anti-inflammatory M2 macrophage polarization in BMDMs thereby affecting systemic inflammation. Overall, our in vivo and ex vivo results highlight the potential of RBO as a dietary mediator that can ameliorate obesity-induced chronic low-grade inflammation by mediating the expression of inflammation-related factors and macrophage polarization.

Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats

2015 ◽  
Vol 66 (2) ◽  
pp. 229-239 ◽  
Author(s):  
V. Shalini ◽  
Ananthasankaran Jayalekshmi ◽  
A. Helen
Keyword(s):  
Rice Bran ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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