Chemical Composition and Hypoglycemic and Pancreas-Protective Effect of Leaf Essential Oil from Indigenous Cinnamon (Cinnamomum osmophloeum Kanehira)

AbstractThe use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties turns out to be an alternative approach to the use of synthetic insecticides. This study aims at investigating the larvicidal, adulticidal activity and the composition of the essential oil of Aeollanthus pubescens Benth on the major malaria vector Anopheles gambiae.The leaves of Aeollanthus pubescens were collected in the South of the Republic of Benin. Three reference strains of Anopheles gambiae s.s. such as Kisumu, Kiskdr and Acerkis were used. The chemical composition of the essential oil was analysed by gas chromatography coupled to mass spectrometry. Larvae were exposed to the essential oil extract for 24 h. Adult mosquitoes were exposed to the fragment nets coated with the essential oil for 3 min. Larval mortality and adult survivorship were monitored.Fourteen components were identified representing 98.31% of the total of oil. The major components were carvacrol (51.06 %), thymyle acetate (14.01 %) and γ-terpinene (10.60 %). The essential oil has remarkable larvicidal properties with LC50 of 29.26, 22.65, and 28.37 ppm respectively on Kisumu, Acerkis and Kiskdr strains. With the fragment net treated at 165 µg/cm2, the KDT50 of both Acerkis (1.71 s, p < 0.001) and Kiskdr (2.67 s, p < 0.001) individuals were significantly lower than that of Kisumu (3.77 s). The lifespan of the three mosquito strains decreased respectively to one day for Kisumu (p < 0.001), two days for Acerkis (p < 0.001) and three days for Kiskdr (p < 0.001) compared to their control.Our findings show that the Aeollanthus pubescens essential oil is an efficient larvicide and adulticide against malaria vector Anopheles gambiae. This bioinsecticidal activity is a promising discovery for the control of the resistant malaria-transmitting vectors.

Download Full-text

Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Molecules ◽

10.3390/molecules26206303 ◽

2021 ◽

Vol 26 (20) ◽

pp. 6303

Author(s):

Arunaksharan Narayanankutty ◽

Krishnaprasad Kunnath ◽

Ahmed Alfarhan ◽

Rajakrishnan Rajagopal ◽

Varsha Ramesh

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Callosobruchus Maculatus ◽

Sitophilus Oryzae ◽

Microbial Pathogens ◽

Traditional Medicines ◽

Significant Toxicity ◽

Leaf Essential Oil ◽

Different Parts

Cinnamomum verum is widely used in traditional medicines, and the different parts of the plant, such as bark, leaves, and flowers, are used for essential oil production. The present study compared the chemical composition of the essential oil of C. verum extracted from the leaves and flowers. In addition, efficacy of these essential oils against the two common pests Sitophilus oryzae and Callosobruchus maculatus was also evaluated. The results indicated the presence of cinnamaldehyde, eugenol, caryophyllene, and linalool in these essential oils, however, at different concentrations. The leaf essential oil was found to be 10–20% more effective as a fumigant against both the pests. Likewise, the leaf essential oil found to repel these pests even at lower concentrations than that of flower essential oil of C. verum. Besides, these essential oils were also effective in controlling the growth of various gram positive and gram negative microbial pathogens and possibly a safeguard for human health. On contrary, both the essential oils were found to be safe for the application on grains, as indicated by their germination potentials. It was also observed that these essential oils do not cause any significant toxicity to guppy fishes, thus confirming their ecological safety for use as a biopesticide.

Download Full-text

Variation of essential oil composition of Eucalyptus camaldulensis (myrtaceae) from the Montengero coastline

Acta periodica technologica ◽

10.2298/apt1041151g ◽

2010 ◽

pp. 151-158 ◽

Cited By ~ 10

Author(s):

Slavenko Grbovic ◽

Dejan Orcic ◽

Maria Couladis ◽

Emilija Jovin ◽

Dusan Bugarin ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Eucalyptus Camaldulensis ◽

Essential Oil Composition ◽

Oil Yield ◽

Oil Composition ◽

Oxygenated Monoterpenes ◽

Sesquiterpene Alcohol ◽

Major Class ◽

Leaf Essential Oil

In the current study the essential oil obtained from the leaves of Eucalyptus camaldulensis plants collected from five localities of the Montenegro coastline was analyzed. The oil yield varied from 0.63 % (Kotor) up to 1.59% (Tivat). The chemical composition of the leaf essential oil was analyzed using GC-MS technique. Monoterpene hydrocarbons were a major class of compounds. Among them, dominant compounds were p-cymene (17.38-28.60%), ?-phellandrene (12.35-14.47%) and ?-pinene (0.94-11.48%). The second largest group was oxygenated monoterpenes with cryptone (4.97-7.25) and terpinene-4-ol (2.75-4.21%) as predominant. Besides high content of sesquiterpene alcohol spathulenol (7.83-14.15%) was found. According to the results obtained E. camaldulensis from Montenegro can be classified in the chemotype with low 1,8-cineole and high p-cymene and cryptone ratio.

Download Full-text

Anti-Proliferative Activity of Piper trioicum Leaf Essential Oil Based on Phytoconstituent Analysis, Molecular Docking and In Silico ADMET Approaches

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207325666211222113239 ◽

2021 ◽

Vol 25 ◽

Author(s):

Sudipta Jena ◽

Asit Ray ◽

Ambika Sahoo ◽

Prabhat Kumar Das ◽

Pradeep Kumar Kamila ◽

...

Keyword(s):

Molecular Docking ◽

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Cell Lines ◽

In Silico ◽

Proliferative Activity ◽

In Silico Admet ◽

Leaf Essential Oil ◽

Ht 29

Background: The essential oils isolated from several medicinal plants are reported to have anticancer activities. Both the essential oil and extracts of many Piper species (Piperaceae) possess potential cytotoxic effect against cancer cell lines and are being used in traditional system of medicine for the treatment of cancer. There is a need to evaluate and validate the anticancer properties of essential oils extracted from other wild species of Piper. Objective: The current research was undertaken to determine the chemical composition and investigate the anti-proliferative activity of wild growing Piper trioicum leaf essential oil. The selected five major constituents were subjected to molecular docking to identify possible modes of binding against serine/threonine-protein kinase (MST3) protein Methods: The essential oil of leaf of P. trioicum was extracted by hydro distillation method and its chemical composition was carried out by GC-FID and GC-MS. The anti-proliferative activity of the essential oil was evaluated by MTT assay against normal (3T3-L1) and various cancer (HCT 116, HT-29, PC-3 and HepG2) cell lines. Molecular docking analysis was performed using AutoDock 4.2 software. The pharmacokinetic and pharmacodynamic properties of the major constituents were determined using absorption, distribution, metabolization, excretion and toxicity (ADMET) analysis. Results: The GC-MS analysis revealed the identification of 45 constituents with δ-cadinene (19.57%), germacrene-D (8.54%), β-caryophyllene (6.84%), 1-epi-cubenol (4.83%) and α-pinene (4.52%) were found to be predominant constituents in the leaf essential oil of P. trioicum. The highest cytotoxicity of essential oil was observed against HT-29 cells (IC50 value of 33.14 µg/ml). 1-epi-cubenol and δ-Cadinene exhibited low binding energy values of -6.25 and -5.92 kcal/mol, respectively. For prediction of in silico pharmacokinetic and druglike properties of the major compounds, ADMET prediction tool was also used, the results of which came within the ideal range. Conclusion: The present findings demonstrated that P. trioicum essential oil possesses significant anti-proliferative activity and could be effective against cancer treatment.

Download Full-text

Chemical Composition and Antioxidant Activity of the Leaf Essential Oil of Schefflera venulosa

Chemistry of Natural Compounds ◽

10.1007/s10600-021-03573-x ◽

2021 ◽

Author(s):

Sudipta Jena ◽

Asit Ray ◽

Ambika Sahoo ◽

Pradeep Kumar Kamila ◽

Sanghamitra Nayak ◽

...

Keyword(s):

Antioxidant Activity ◽

Chemical Composition ◽

Essential Oil ◽

Leaf Essential Oil

Download Full-text

The Leaf Essential Oil of Acorus macrospadiceus (Yam.) F. N. Wei & Y. K. Li from Vietnam: Chemical Composition and Antimicrobial Activity

Journal of Essential Oil Bearing Plants ◽

10.1080/0972060x.2021.1978871 ◽

2021 ◽

Vol 24 (4) ◽

pp. 745-752

Author(s):

Nguyen Anh Dung ◽

Le Thi Huong ◽

Do Ngoc Dai ◽

Isiaka Ajani Ogunwande

Keyword(s):

Antimicrobial Activity ◽

Chemical Composition ◽

Essential Oil ◽

Leaf Essential Oil

Download Full-text

Chemical Composition, Enantiomeric Distribution, and Biological Activities of Rhododendron anthopogon Leaf Essential Oil from Nepal

Natural Product Communications ◽

10.1177/1934578x1601101230 ◽

2016 ◽

Vol 11 (12) ◽

pp. 1934578X1601101 ◽

Cited By ~ 2

Author(s):

Noura S. Dosoky ◽

Prabodh Satyal ◽

Suraj Pokharel ◽

William N. Setzer

Keyword(s):

Gas Chromatography ◽

Chemical Composition ◽

Essential Oil ◽

Biological Activities ◽

Gas Chromatography Mass Spectrometry ◽

Volatile Components ◽

Cytotoxic Activities ◽

Blood Disorders ◽

Leaf Essential Oil ◽

Microbroth Dilution

Rhododendron anthopogon D. Don., a small compact Himalayan shrub growing in Nepal, is a known medicinal plant used to treat sore throat, colds, blood disorders, bone disease, potato allergies, and vomiting, and to relieve liver disorders, headaches and back pain. The present study investigated the chemical composition and bioactivities of the leaf essential oil from R. anthopogon from Dhankuta, Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography – mass spectrometry (GC-MS). The enantiomeric distribution of monoterpenoid components was determined using chiral gas chromatography and represents the first chiral examination of R. anthopogon essential oil. The essential oil was screened for antimicrobial activity using the microbroth dilution test, and for cytotoxic activity against MCF-7, MDA-MB-231, and 5637 using the MTT assay. A total of 70 volatile components were identified from the essential oil. The major components were α-pinene (21.5%), δ-cadinene (13.8%), β-pinene (9.5%), limonene (5.9%), δ-amorphene (4.6%), α-muurolene (4.5%), and ( E)-caryophyllene (3.2%) with other minor constituents (< 3%). The essential oil showed marginal antibacterial and cytotoxic activities, but no antifungal effects.

Download Full-text

Composition and in-vitro CytotoxicActivities of the Leaf Essential Oil of Beilschmiedia erythrophloia from Taiwan

Natural Product Communications ◽

10.1177/1934578x1300800135 ◽

2013 ◽

Vol 8 (1) ◽

pp. 1934578X1300800

Author(s):

Yu-Chang Su ◽

Chen-Lung Ho

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Cytotoxic Activity ◽

Cancer Cells ◽

Cytotoxic Activities ◽

Anticancer Activities ◽

Leaf Essential Oil ◽

Main Components ◽

Type Apparatus

This study investigated the chemical composition and in-vitro cytotoxic activities of the essential oil isolated from the leaf of Beilschmiedia erythrophloia. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Fifty-five compounds were identified, representing 100% of the oil. The main components identified were β-caryophyllene (22.6%), α-humulene (21.9%), terpinen-4-ol (5.3%), cis-β-ocimene (5.1%), sabinene (5.0%) and limonene (4.5%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells.

Download Full-text