scholarly journals Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6303
Author(s):  
Arunaksharan Narayanankutty ◽  
Krishnaprasad Kunnath ◽  
Ahmed Alfarhan ◽  
Rajakrishnan Rajagopal ◽  
Varsha Ramesh
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Callosobruchus Maculatus ◽  
Sitophilus Oryzae ◽  
Microbial Pathogens ◽  
Traditional Medicines ◽  
Significant Toxicity ◽  
Leaf Essential Oil ◽  
Different Parts

Cinnamomum verum is widely used in traditional medicines, and the different parts of the plant, such as bark, leaves, and flowers, are used for essential oil production. The present study compared the chemical composition of the essential oil of C. verum extracted from the leaves and flowers. In addition, efficacy of these essential oils against the two common pests Sitophilus oryzae and Callosobruchus maculatus was also evaluated. The results indicated the presence of cinnamaldehyde, eugenol, caryophyllene, and linalool in these essential oils, however, at different concentrations. The leaf essential oil was found to be 10–20% more effective as a fumigant against both the pests. Likewise, the leaf essential oil found to repel these pests even at lower concentrations than that of flower essential oil of C. verum. Besides, these essential oils were also effective in controlling the growth of various gram positive and gram negative microbial pathogens and possibly a safeguard for human health. On contrary, both the essential oils were found to be safe for the application on grains, as indicated by their germination potentials. It was also observed that these essential oils do not cause any significant toxicity to guppy fishes, thus confirming their ecological safety for use as a biopesticide.

Anti-Proliferative Activity of Piper trioicum Leaf Essential Oil Based on Phytoconstituent Analysis, Molecular Docking and In Silico ADMET Approaches

2021 ◽  
Vol 25 ◽  
Author(s):  
Sudipta Jena ◽  
Asit Ray ◽  
Ambika Sahoo ◽  
Prabhat Kumar Das ◽  
Pradeep Kumar Kamila ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Cell Lines ◽  
In Silico ◽  
Proliferative Activity ◽  
In Silico Admet ◽  
Leaf Essential Oil ◽  
Ht 29

Background: The essential oils isolated from several medicinal plants are reported to have anticancer activities. Both the essential oil and extracts of many Piper species (Piperaceae) possess potential cytotoxic effect against cancer cell lines and are being used in traditional system of medicine for the treatment of cancer. There is a need to evaluate and validate the anticancer properties of essential oils extracted from other wild species of Piper. Objective: The current research was undertaken to determine the chemical composition and investigate the anti-proliferative activity of wild growing Piper trioicum leaf essential oil. The selected five major constituents were subjected to molecular docking to identify possible modes of binding against serine/threonine-protein kinase (MST3) protein Methods: The essential oil of leaf of P. trioicum was extracted by hydro distillation method and its chemical composition was carried out by GC-FID and GC-MS. The anti-proliferative activity of the essential oil was evaluated by MTT assay against normal (3T3-L1) and various cancer (HCT 116, HT-29, PC-3 and HepG2) cell lines. Molecular docking analysis was performed using AutoDock 4.2 software. The pharmacokinetic and pharmacodynamic properties of the major constituents were determined using absorption, distribution, metabolization, excretion and toxicity (ADMET) analysis. Results: The GC-MS analysis revealed the identification of 45 constituents with δ-cadinene (19.57%), germacrene-D (8.54%), β-caryophyllene (6.84%), 1-epi-cubenol (4.83%) and α-pinene (4.52%) were found to be predominant constituents in the leaf essential oil of P. trioicum. The highest cytotoxicity of essential oil was observed against HT-29 cells (IC50 value of 33.14 µg/ml). 1-epi-cubenol and δ-Cadinene exhibited low binding energy values of -6.25 and -5.92 kcal/mol, respectively. For prediction of in silico pharmacokinetic and druglike properties of the major compounds, ADMET prediction tool was also used, the results of which came within the ideal range. Conclusion: The present findings demonstrated that P. trioicum essential oil possesses significant anti-proliferative activity and could be effective against cancer treatment.

scholarly journals Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of Annona muricata L. (Soursop) from Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Joseph Nana Gyesi ◽  
Rita Opoku ◽  
Lawrence Sheringham Borquaye
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Moderate Activity ◽  
Annona Muricata ◽  
Fruit Pulp ◽  
Leaf Essential Oil

Annona muricata, also called soursop, is widespread in many tropical countries, and various parts of the plant have been shown to possess very good pharmacological properties. This work evaluated the chemical composition and antioxidant activities of essential oils obtained from the fruit pulp and leaves of soursop. Essential oils were obtained via hydrodistillation and characterized by gas chromatography-mass spectrometry. Antioxidant potential was evaluated via the phosphomolybdenum, hydrogen peroxide scavenging, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. In the leaf essential oil, a total of 31 compounds were identified with δ-cadinene (22.58%) and α-muurolene (10.64%) being the most abundant. Thirty-two compounds were identified in the fruit pulp essential oil with Ç-sitosterol (19.82%) and 2-hydroxy-1-(hydroxymethyl) ethyl ester (13.48%) being present in high amounts. Both essential oils showed very good total antioxidant capacities (49.03 gAAE/100 g and 50.88 gAAE/100 g for fruit pulp and leaf essential oils, respectively). The IC50 values from the DPPH assay were 244.8 ± 3.2 μg/mL for leaf essential oil and 512 ± 5.1 μg/mL for the fruit pulp essential oil. At 1 mg/mL, hydrogen peroxide scavenged was below 50% for both leaf and fruit pulp essential oils, indicating moderate activity. These results suggest possible application of the essential oils of Annona muricata in food preservation and processing.

A comparative analysis of bark and leaf essential oil and their chemical composition, antioxidant, anti-inflammatory, antimicrobial activities and genotoxic potential of North East Indian Cinnamomum zeylanicum Blume

2019 ◽  
Vol 09 ◽  
Author(s):  
Roktim Gogoi ◽  
Neelav Sarma ◽  
Rikraj Loying ◽  
Sudin Kumar Pandey ◽  
Twahira Begum ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Protein Denaturation ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Cinnamomum Zeylanicum ◽  
North East ◽  
Leaf Essential Oil ◽  
Anti Inflammatory

Background: Cinnamomum zeylanicum Blume bark and leaf essential oil possesses eugenol as the major component. Both the essential oil have the potential antioxidant, anti-inflammatory, antimicrobial and negligible genotoxicity. Objective: A comparative chemical composition and biological evaluation of Cinnamomum zeylanicum Blume, bark and leaf essential oils, originated from North-East India has been investigated in the present study. Methods: Gas chromatography/mass spectroscopy analysis was used to investigate the chemical composition of the essential oil samples. DPPH free radical scavenging activity, reducing power assay was used for antioxidant activity evaluation. Similarly, egg albumin denaturation assay, protease inhibitory activities were used for anti-inflammatory activity, while genotoxicity was evaluated by using Allium cepa assay. Results: The results showed that eugenol is the major component of C. zeylanicum bark (84.48%) and leaf (48.78 %) essential oil. Significant antioxidant activity were observed for both essential oils in the DPPH free radical scavenging assay (IC50= 103.2 μg/mL, bark; IC50= 234.7 μg/mL, leaf), and reducing power assay (absorbance of 1.802 nm, 0.907 nm in 48 µg/mL for bark and leaf essential oil respectively). In-vitro anti-inflammatory activity revealed strong potential of leaf essential oil (protein denaturation assay, IC50= 0.05279 μg/mL; protease inhibitory activity IC50= 3.607 μg/mL) in comparison to bark essential oil (protein denaturation assay IC50= 0.1491, protease inhibitory activity IC50= 61.06). Allium cepa root growth test, mitotic index, and chromosomal aberration test were performed to investigate the genotoxicity of C. zeylanicum bark and leaf essential oil, which resulted no toxic nature of both the essential oils. Antimicrobial activity against eight bacterial and fungal strains revealed good antimicrobial properties with the MIC value of Staphylococcus aureus at 5 μL/mL (bark), Aspergillus niger at 2.5 μL/mL (bark); Bacillus cereus at 5 μL/mL (leaf), Aspergillus niger at 2.5 μL/mL (leaf). Conclusion: Collectively, these findings indicated the strong biological potential of both essential oils, although bark essential possesses better biologically activities than the leaf essential oil and could be used in the food and beverages industries.

scholarly journals Chemical Composition and Anti-mildew Activities of Essential Oils from Different Parts of Michelia compressa var. formosana

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000
Author(s):  
Yu-Chang Su ◽  
Kuang-Ping Hsu ◽  
Eugene I-Chen Wang ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Main Constituent ◽  
Germacrene D ◽  
Leaf Oil ◽  
Essential Oil Yield ◽  
Different Parts ◽  
Type Apparatus

In this study, anti-mildew activities of the essential oils of the leaves, wood, twigs, flowers, and their constituents from Michelia compressa var. formosana were evaluated in vitro against 7 mildew fungi. The main compounds responsible for the anti-mildew activities were isolated and identified. The essential oils from the fresh leaves, wood, twigs, and flowers of M. compressa var. formosana were isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. The essential oil yield from the flowers was the highest, and the oils obtained from the 4 parts of the tree were composed mainly of sesquiterpenoids. The leaf oil consisted primarily of α-cadinol (18.9%) and germacrene D (18.5%); the twig oil's main constituent was α-cadinol (19.1%); the wood oil's major components were α-cadinol (25.7%) and β-eudesmol (20.2%); and the flower oil contained α-cadinol (11.4%). Comparing the anti-mildew activities of the oils suggested that wood oil was the most effective. Further fractionation of the wood oil produced α-cadinol, β-eudesmol, τ-cadinol, and elemol. The 4 compounds exhibit very strong anti-mildew activities, and these in descending order are α-cadinol, elemol, β-eudesmol, and τ-cadinol. For the anti-mildew activities of the wood oil, the active source compounds were determined to be α-cadinol, elemol, β-eudesmol, and τ-cadinol.

scholarly journals Screening of Chemical Composition, in vitro Antioxidant, α-Amylase and α-Glucosidase Inhibitory Activities of the Leaf Essential Oils of Cinnamomum wightii from Different Populations

2018 ◽  
Vol 13 (11) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Venkatraman Sriramavaratharajan ◽  
Ramar Murugan
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Slow Release ◽  
Leaf Essential Oil ◽  
Different Populations ◽  
Inhibitory Activities ◽  
The Western Ghats ◽  
Nutraceutical Products

Cnnamomum wightii is an endemic species of the Western Ghats, India and is used in Ayurveda and Siddha systems of medicine. Its bark and leaves are adulterated with commercial cinnamon in southern India. Despite its medicinal and commercial importance, the species remains underexplored. The objective of the present work was to screen the chemical composition, in vitro antioxidant, α-amylase and α-glucosidase inhibitory activities of the leaf essential oil of C. wightii collected from different populations. GC-FID and GC-MS analyses of the leaf essential oils from seven accessions enabled the identification of a total of 70 constituents, of which only 16 compounds were present in all samples. Eleven major constituents (> 5%) were identified, of which only linalool and spathulenol were present in all accessions as major constituents. Among seven accessions, essential oil from Parson's valley, Nilgiris exhibited better antioxidant activity with IC50 values of 2.552 ± 0.13 and 3.485 ± 0.09 mg/mL for ABTS and DPPH respectively. The essential oil from Korakundah, Nilgiris showed better hypoglycemic activity with IC50 values of 1.617 ± 0.02 and 1.146 ± 0.02 mg/mL for α-amylase and α-glucosidase inhibitory activities respectively. The leaf essential oils of C. wightii may be used in nutraceutical products focusing diabetes mellitus as the moderate inhibition of the metabolic enzymes has the advantage of slow release of glucose.

scholarly journals ANALYSIS OF ESSENTIAL OIL CONSTITUENTS OF THREE ANNONA SPECIES GROWING IN KERALA, INDIA

2021 ◽  
Vol 12 (5) ◽  
pp. 45-48
Author(s):  
Sonia Mol Joseph ◽  
Amala Dev A R
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectrometry Analysis ◽  
South Indian ◽  
Germacrene D ◽  
Leaf Essential Oil ◽  
The Common

The volatile chemical composition of leaf essential oils of three Annona species (Annona cherimola, Annona muricata and Annona squamosa) from the different regions of Kerala, South Indian was determined using gas chromatography-mass spectrometry analysis. A total of 41 constituents belonging to monoterpenoids, sesquiterpenoids and diterpenoids were identified. Monoterpenes and sesquiterpenoids were the major class of volatile compounds in most of the Annona species examined. The study led to the identification of major compounds as germacrene D (23.5%), bicyclogermacrene (14.6%) and β-caryophyllene (11.7%) in A. cherimola, α-pinene (13.3%), β-caryophyllene (11.2%) and β-pinene (10.1%) in A. muricata, and β-caryophyllene (11.9%) and α-pinene (8.2%) in A. squamosa respectively. The examined essential oils showed that β-caryophyllene is the common constituent identified in all the three species and other constituents are more specific for each species under study. Present investigation reports, a comparison of essential oil compositions of three Annona species from Kerala. Results of this study prove that essential oils examined have considerable dissimilarity in chemical composition with previously reported leaf essential oil compositions from other regions. A chemotaxonomic analysis of these essential oils based on the distribution of compounds has revealed an efficient method to differentiate Annona species unambiguously.

scholarly journals Blood Cortisol Level and Blood Serotonin Level in Depression Mice with Basil Leaf Essential Oil Treatment

2019 ◽  
Vol 7 (16) ◽  
pp. 2652-2655
Author(s):  
Machnizar Sentari ◽  
Urip Harahap ◽  
Tuti Wahmurti A. Sapiie ◽  
Kiking Ritarwan
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Cortisol Level ◽  
Work Productivity ◽  
Public Health Problem ◽  
Serotonin Level ◽  
Traditional Medicines ◽  
Leaf Essential Oil ◽  
Cortisol Levels ◽  
The Impact

BACKGROUND: Depression is a serious public health problem. The impact of depression is enormous, ranging from decreasing work productivity, interpersonal disorders, sleep and eating disorders, susceptible to disease to an increase in suicides. In a state of depression, there was an increase in cortisol and changes in the neurotransmitter of the brain monoamine, norepinephrine and dopamine and specifically serotonin level. Treatment of depression using synthetic drugs such as the Selective Serotonin Reuptake Inhibitor (SSRI) drug which is said to be safe turns out to still have side effects, such as stomach disorders, erectile disorders, weight gain and sometimes sleep disorders. So, the usage of traditional medicines can be an alternative. One of the traditional medicines that have been studied in Indonesia was the essential oil of basil leaves, which is known to function as an antidepressant at a dose of 2.5 x 10-2 mL/kg b.w. AIM: To determine the comparison of cortisol and serotonin level between depressed mice which get basil leaf essential oil as intervention, depression mice, and normal mice. METHODS: This research was an experimental type purely using experimental animal models, with an experimental research design Post Test Only Context Group Design in mice (Mus musculus), by dividing 3 groups of mice, namely depressed mice which received essential oil of basil leaves dose of 2.5 x 10-2 mL/kg BW, depression mice, and normal mice, to compare the level of blood cortisol and serotonin while to determine effect of administration basil leaves essential oils in depression mice. RESULTS: Cortisol levels between intervened depression mice, depression mice, and normal mice groups were significantly comparable with p < 0.001, while serotonin level was significantly comparable between intervened depression mice, depression mice, and normal mice group with p < 0.001. CONCLUSION: Evidenced by differences in cortisol levels, serotonin levels between normal mice groups, depressed mice and mice that received essential oils of basil leaves. The comparisons showed that the cortisol level of the intervened depression group was lower than the depression mice group; however the level didn’t reach the level of cortisol in the normal group. While the serotonin level of intervened depression mice group was higher than the depression mice group or normal mice group.

scholarly journals Essential oil composition of three Cryptocarya species from Malaysia

2020 ◽  
Vol 75 (7-8) ◽  
pp. 297-301
Author(s):  
Muhammad Ammar Mohd Azhar ◽  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Shamsul Khamis
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Essential Oil Composition ◽  
Gas Chromatography Mass Spectrometry ◽  
Skin Infections ◽  
Oil Composition ◽  
Traditional Medicines ◽  
Total Oil

AbstractCryptocarya species are mainly distributed in Africa, Asia, Australia and South America, widely used in traditional medicines for the treatment of skin infections and diarrhea. The present investigation reports on the extraction by hydrodistillation and the chemical composition of three Cryptocarya species (Cryptocarya impressa, Cryptocarya infectoria, and Cryptocarya rugulosa) essential oils from Malaysia. The chemical composition of these essential oils was fully characterized by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of 51 components were identified in C. impressa, C. infectoria, and C. rugulosa essential oils representing 91.6, 91.4, and 83.0% of the total oil, respectively. The high percentages of α-cadinol (40.7%) and 1,10-di-epi-cubenol (13.4%) were found in C. impressa oil. β-Caryophyllene (25.4%) and bicyclogermacrene (15.2%) were predominate in C. infectoria oil. While in C. rugulosa oil, bicyclogermacrene (15.6%), δ-cadinene (13.8%), and α-copaene (12.3%) were predominate. To the best of our knowledge, there is no report on the essential oil composition of these three species.

scholarly journals Seasonal Variation in the Leaf Essential Oil Composition of Zanthoxylum clava-herculis growing in Huntsville, Alabama

2010 ◽  
Vol 5 (3) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Lauren C. Eiter ◽  
Henry Fadamiro ◽  
William N. Setzer
Keyword(s):  
Seasonal Variation ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Growing Season ◽  
Essential Oil Composition ◽  
Oil Composition ◽  
Monoterpene Hydrocarbons ◽  
Leaf Essential Oil ◽  
Individual Trees

The seasonal variation in the chemical composition of the leaf essential oil of Zanthoxylum clava-herculis has been analyzed by GC-MS. Three individual trees were sampled four times during the course of the 2004 growing season. Notable differences were recorded in the essential oil yields from the three trees on the four collection dates; yields were highest in May and lowest in July The leaf essential oils were made up of 25 components, largely menthane monoterpenoids, dominated by limonene (44-73%) and 1,8-cineole (16-43%), with lesser amounts of α-thujene, linalool, γ-terpinene, and α-terpineol. The ratio of oxygenated monoterpenoids to monoterpene hydrocarbons generally increased during the season, largely reflected in the 1,8-cineole/limonene ratio.

Comparative Evaluation of the Chemical Composition of Essential Oil from Twig, Leaf and Root of Clerodendrum inerme (L.) Gaertn

2011 ◽  
Vol 343-344 ◽  
pp. 22-27 ◽  
Author(s):  
Dong Hai Li ◽  
Zhao Wang ◽  
Zhen Yi Liang ◽  
Xiao Bo Yang ◽  
Jing Xu
Keyword(s):  
Linoleic Acid ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Comparative Evaluation ◽  
Dibutyl Phthalate ◽  
The Other ◽  
Main Component ◽  
Different Parts

This study was designed to comparative evaluate the chemical composition of the essential oil from twig, leaf and root parts ofClerodendrum inerme(L.)Gaertn. GC-MS analyses of the oils revealed the presence of 8, 8 and 6 compounds in the essential oils obtained by hydrodistillation from different parts, respectively. Higher amounts of esters were found to compose a major chemotype in diverse parts of the plant. Dibutyl phthalate was the main component of all the essential oils attaining in average 34.22%, 59.28% and 44.27% and the other kind of esters accounted for 38.30%, 17.28% and 10.89% in the twig, leaf and root parts, respectively. In addition, some pharmaceutical components such as stigmasterol, linoleic acid and ferruginol were discovered. The study offers theoretic basis for utilization of the traditional folk herbC. inerme.

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