Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway

2010 ◽  
Vol 58 (5) ◽  
pp. 2935-2942 ◽  
Author(s):  
Kuang-Chi Lai ◽  
An-Cheng Huang ◽  
Shu-Chun Hsu ◽  
Chao-Lin Kuo ◽  
Jai-Sing Yang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Matrix Metalloproteinase ◽  
Signaling Pathway ◽  
Human Colon ◽  
Mapk Signaling ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Human Colon Cancer ◽  
Benzyl Isothiocyanate ◽  
Ht29 Cells

Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 Cells

2010 ◽  
Vol 58 (20) ◽  
pp. 11148-11155 ◽  
Author(s):  
Kuang-Chi Lai ◽  
Shu-Chun Hsu ◽  
Chao-Lin Kuo ◽  
Siu-Wan Ip ◽  
Jai-Sing Yang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Human Colon ◽  
Migration And Invasion ◽  
Signal Transduction Pathways ◽  
Phenethyl Isothiocyanate ◽  
Human Colon Cancer ◽  
Multiple Signal ◽  
Ht29 Cells

scholarly journals MiR-34b inhibits the proliferation and promotes apoptosis in colon cancer cells by targeting Wnt/β-catenin signaling pathway

2019 ◽  
Vol 39 (10) ◽  
Author(s):  
Kailun Ye ◽  
Chunhua Xu ◽  
Tongguan Hui
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Colon ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Tumor Tissues

Abstract Colon cancer is one of the leading cause of cancer deaths that is severely threatening human health. Several microRNAs (miRNAs) have been found to be associated with the tumor genesis of colon cancer. The present study determined the expression of miR-34b in patients with colon cancer and studied the molecular mechanism of miR-34b in the proliferation and apoptosis of human colon cancer Caco-2 cells in vitro. In colon cancer patients, the expression of miR-34b was decreased in tumor tissues when compared with the adjacent non-tumor tissues. Furthermore, overexpression of miR-34b inhibited proliferation, migration and invasion, while promoted apoptosis in colon cancer cells. The online bioinformatics sites predicted possible regulatory genes of miR-34b and luciferase reporter assay verify that β-catenin was a direct target of miR-34b. Furthermore, miR-34b overexpression significantly decreased the expression of genes associated with Wnt/β-catenin signaling pathway. In conclusion, our results suggest that miR-34b may inhibit migration and invasion of human colon cancer cells by regulating Wnt/β-catenin signaling and miR-34b may be a key target for the treatment and diagnosis of colon cancer.

scholarly journals Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yu-hong Yuan ◽  
Han-yu Wang ◽  
Yu Lai ◽  
Wa Zhong ◽  
Wei-ling Liang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Human Colon ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Human Colon Cancer ◽  
Epigenetic Inactivation

scholarly journals Antimetastatic Effects of Sesamin on Human Head and Neck Squamous Cell Carcinoma through Regulation of Matrix Metalloproteinase-2

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2248 ◽  
Author(s):  
Jian-Ming Chen ◽  
Pei-Yin Chen ◽  
Chia-Chieh Lin ◽  
Ming-Chang Hsieh ◽  
Jen-Tsun Lin
Keyword(s):  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Head And Neck ◽  
Mapk Pathway ◽  
Human Head ◽  
Mapk Signaling ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Dependent Manner

Background: Sesamin is a lignin present in sesame oil from the bark of Zanthoxylum spp. Sesamin reportedly has anticarcinogenic potential and exerts anti-inflammatory effects on several tumors. Hypothesis/Purpose: However, the effect of sesamin on metastatic progression in human head and neck squamous carcinoma (HNSCC) remains unknown in vitro and in vivo; hence, we investigated the effect of sesamin on HNSCC cells in vitro. Methods and Results: Sesamin-treated human oral cancer cell lines FaDu, HSC-3, and Ca9-22 were subjected to a wound-healing assay. Furthermore, Western blotting was performed to assess the effect of sesamin on the expression levels of matrix metalloproteinase (MMP)-2 and proteins of the MAPK signaling pathway, including p-ERK1/2, P-p38, and p-JNK1/2. In addition, we investigated the association between MMP-2 expression and the MAPK pathway in sesamin-treated oral cancer cells. Sesamin inhibited cell migration and invasion in FaDu, Ca9-22, and HSC-3 cells and suppressed MMP-2 at noncytotoxic concentrations (0 to 40 μM). Furthermore, sesamin significantly reduced p38 MAPK and JNK phosphorylation in a dose-dependent manner in FaDu and HSC-3 cells. Conclusions: These results indicate that sesamin suppresses the migration and invasion of HNSCC cells by regulating MMP-2 and is thus a potential antimetastatic agent for treating HNSCC.

scholarly journals Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56369 ◽  
Author(s):  
Cagri Bodur ◽  
Ozgur Kutuk ◽  
Gizem Karsli-Uzunbas ◽  
Tayirjan T. Isimjan ◽  
Paul Harrison ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Human Colon ◽  
Mapk Signaling ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells

2011 ◽  
Vol 415 (2) ◽  
pp. 319-324 ◽  
Author(s):  
Jean-Pierre Raufman ◽  
Kunrong Cheng ◽  
Neeraj Saxena ◽  
Ahmed Chahdi ◽  
Angelica Belo ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Muscarinic Receptor ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Receptor Agonists ◽  
Matrix Metalloproteinase 1 ◽  
Human Colon Cancer Cells
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