Design and Syntheses of Permethyl Ningalin B Analogues: Potent Multidrug Resistance (MDR) Reversal Agents of Cancer Cells

2010 ◽  
Vol 53 (14) ◽  
pp. 5108-5120 ◽  
Author(s):  
Pu Yong Zhang ◽  
Iris L. K. Wong ◽  
Clare S. W. Yan ◽  
Xiao Yu Zhang ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Reversal Agents ◽  
Mdr Reversal

Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii

2021 ◽  
Vol 19 (1) ◽  
pp. 216-219
Author(s):  
Zi-Zhen Zhang ◽  
Yan-Rong Zeng ◽  
Ya-Nan Li ◽  
Zhan-Xing Hu ◽  
Lie-Jun Huang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Mdr Reversal ◽  
Mcf 7

Two rare seco-polycyclic polyprenylated acylphloroglucinols (1 and 2) were isolated from Hypericum sampsonii. Compounds 1 and 2 showed moderate multidrug resistance (MDR) reversal activity to resistant cancer cells, HepG2/ADR and MCF-7/ADR.

scholarly journals The Effects of Synthetically Modified Natural Compounds on ABC Transporters

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 127 ◽  
Author(s):  
Daniel Dantzic ◽  
Pawan Noel ◽  
Fabrice Merien ◽  
Dong-Xu Liu ◽  
Jun Lu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Survival Rate ◽  
Abc Transporter ◽  
Abc Transporters ◽  
Drug Absorption ◽  
Natural Compounds ◽  
Cellular Tissue ◽  
Reversal Agents ◽  
Atp Binding Cassette Transporters ◽  
Mdr Reversal

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR.

Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells

2010 ◽  
Vol 18 (8) ◽  
pp. 2964-2975 ◽  
Author(s):  
Juan Xiong ◽  
Masatoshi Taniguchi ◽  
Yoshiki Kashiwada ◽  
Michiko Sekiya ◽  
Takashi Yamagishi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Reversal Agents ◽  
Papyriferic Acid

Ingol diterpenoids as P-glycoprotein-dependent multidrug resistance (MDR) reversal agents from Euphorbia marginata

2020 ◽  
Vol 95 ◽  
pp. 103546 ◽  
Author(s):  
Yao Zhang ◽  
Run-Zhu Fan ◽  
Jun Sang ◽  
Yi-Jing Tian ◽  
Jia-Qi Chen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Mdr Reversal

ChemInform Abstract: Synthesis of a Novel Series of (E,E)-4,6-Bis(styryl)-2-O-glycopyranosyl-pyrimidines and Their Potent Multidrug Resistance (MDR) Reversal Activity Against Cancer Cells.

ChemInform ◽  
2013 ◽  
Vol 44 (15) ◽  
pp. no-no
Author(s):  
Lei Gao ◽  
Qian Liu ◽  
Sumei Ren ◽  
Shengbiao Wan ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Mdr Reversal

scholarly journals Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells

Biology ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 75 ◽  
Author(s):  
Yuanyuan Zhou ◽  
Po-yee Chung ◽  
Jessica Yuen-wuen Ma ◽  
Alfred King-yin Lam ◽  
Simon Law ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Underlying Mechanism ◽  
Quinoline Derivative ◽  
Parental Cancer ◽  
Reversal Effect ◽  
P Glycoprotein ◽  
Mdr Reversal

Multidrug resistance (MDR) is one of conventional cancer chemotherapy’s limitations. Our group previously synthesized a series of quinoline-based compounds in an attempt to identify novel anticancer agents. With a molecular docking analysis, the novel compound 160a was predicted to target p-glycoprotein, an MDR candidate. The purpose of this study is to evaluate 160a’s MDR reversal effect and investigate the underlying mechanism at the molecular level. To investigate 160a’s inhibitory effect, we used a series of parental cancer cell lines (A549, LCC6, KYSE150, and MCF-7), the corresponding doxorubicin-resistant cell lines, an MTS cytotoxicity assay, an intracellular doxorubicin accumulation test, and multidrug resistance assays. The Compusyn program confirmed, with a combination index (CI) value greater than 1, that 160a combined with doxorubicin exerts a synergistic effect. Intracellular doxorubicin accumulation and transported calcein acetoxymethyl (AM) (a substrate for p-glycoprotein) were both increased when cancer cells with MDR were treated with compound 160a. We also showed that compound 160a’s MDR reversal effect can persist for at least 1 h. Taken together, these results suggest that the quinoline compound 160a possesses high potential to reverse MDR by inhibiting p-glycoprotein-mediated drug efflux in cancer cells with MDR.

scholarly journals Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

2020 ◽  
Vol 10 (2) ◽  
pp. 327-343 ◽  
Author(s):  
Senling Feng ◽  
Huifang Zhou ◽  
Deyan Wu ◽  
Dechong Zheng ◽  
Biao Qu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Total Synthesis ◽  
Reversal Agents ◽  
Mdr Reversal

ChemInform Abstract: Discovery of Highly Potent Multidrug Resistance (MDR) Reversal Agents: Aminosulfonylaryl Isoxazole Derivatives.

ChemInform ◽  
2009 ◽  
Vol 40 (36) ◽  
Author(s):  
Young Taek Han ◽  
Eun Kyung Kim ◽  
Eun Ae Kim ◽  
Eun Seon Kim ◽  
Dae Kyong Kim ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Reversal Agents ◽  
Isoxazole Derivatives ◽  
Mdr Reversal
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