Development of new predictive equations for basal metabolic rate in Iranian healthy adults: negligible effect of sex

2020 ◽  
pp. 1-10
Author(s):  
Bahareh Nikooyeh ◽  
Nastaran Shariatzadeh ◽  
Ali Kalayi ◽  
Maliheh Zahedirad ◽  
Tirang R. Neyestani
Keyword(s):  
Metabolic Rate ◽  
Thyroid Function ◽  
Basal Metabolic Rate ◽  
Age Groups ◽  
Thyroid Function Tests ◽  
Anthropometric Measures ◽  
Predictive Equations ◽  
Normal Thyroid Function ◽  
Asian People ◽  
Predictive Formulas

Abstract. Some studies have reported inaccuracy of predicting basal metabolic rate (BMR) by using common equations for Asian people. Thus, this study was undertaken to develop new predictive equations for the Iranian community and also to compare their accuracy with the commonly used formulas. Anthropometric measures and thyroid function were evaluated for 267 healthy subjects (18–60 y). Indirect calorimetry (InCal) was performed only for those participants with normal thyroid function tests (n = 252). Comparison of predicted RMR (both kcal/d and kcal.kg.wt−1.d−1) using current predictive formulas and measured RMR revealed that Harris-Benedict and FAO/WHO/UNU significantly over-estimated and Mifflin-St. Jeor significantly under-estimated RMR as compared to InCal measurements. In stepwise regression analysis for developing new equations, the highest r2 (=0.89) was from a model comprising sex, height and weight. However, further analyses revealed that unlike the subjects under 30 y, the association between age and the measured RMR in subjects 30 y and plus was negative (r = −0.241, p = 0.001). As a result, two separate equations were developed for these two age groups. Over 80 percent of variations were covered by the new equations. In conclusion, there were statistical significant under- and over-estimation of RMR using common predictive equations in our subjects. Using the new equations, the accuracy of the calculated RMR increased remarkably.

scholarly journals Measured and Predicted Basal Metabolic Rate in Inflammatory Bowel Disease Patients

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 624-624
Author(s):  
Luiz Dos Anjos ◽  
Tatiana Campos ◽  
Juliana Dantas ◽  
Fernanda Fernandes ◽  
Vivian Wahrlich
Keyword(s):  
Inflammatory Bowel Disease ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Bowel Disease ◽  
Anthropometric Measures ◽  
Predictive Equations ◽  
Women Subjects ◽  
Funding Sources ◽  
Chron's Disease ◽  
Inflammatory Bowel

Abstract Objectives To measure basal metabolic rate (BMR) and to compare the values with estimated BMR from international and local predictive equations in inflammatory bowel disease (IBD) patients. Methods A total of 72 (38 women) subjects with Chron's disease (n = 45, 19 women) and ulcerative colitis (n = 27, 19 women) from an outpatient care unit in Rio de Janeiro, Brazil, agreed to participate in the study. Anthropometric measures were obtained using standard procedures. Percent body fat (PBF) was assessed by DXA. BMR was measured (BMRm) by indirect calorimetry (Vmax Encore 29) under standardized conditions and compared with BMR estimated by internationally-recommended (Schofield, 1985) and locally-developed (Anjos et al., 2014) predictive equations. Bias was calculated as estimated - measured BMR. Results The mean ± SD (range) age was 38.0 ± 11.3 (20.1 – 58.3) years with a mean BMI of 24.7 ± 4.5 (16.1 – 39.1) kg.m−2 and PBF of 32.2 ± 9.1 (9.7 – 53.4). BMRm was significantly lower in women (1169.3 ± 205.0) than men (1439.0 ± 197.5) kcal.day−1. The Schofield's equations significantly overestimated BMR for both women (bias of 204.0 ± 148.3 kcal.day−1 or 17.4%) and men (306.7 ± 171.0 kcal.day−1 or 21.3%). The locally-developed equation yielded nonsignificant estimates for both women (−5.8 ± 143.7 kcal.day−1 or −0.5%) and men (−19.9 ± 165.5 kcal.day−1 or −1.4%). Conclusions The findings of the present study indicate that internationally-recommended BMR predictive equations are not accurate to estimate BMR in IBD patients in a tropical setting. As observed in samples of healthy adults from the same city, the locally-developed BMR equations yield unbiased and accurate estimates for IBD patients. Funding Sources CNPq (310,461/2016–20) and FAPERJ (E-26/202.514/2018; E-26/203.068/2018; E-26/203.068/2017; E-26/202.520/2016; E-26/210.747/2016).

scholarly journals Validation of three predictive equations for basal metabolic rate in adults

2005 ◽  
Vol 8 (7a) ◽  
pp. 1213-1228 ◽  
Author(s):  
Manuel Ramirez-Zea
Keyword(s):  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Age Groups ◽  
Normal Weight ◽  
Prediction Errors ◽  
Concordance Correlation ◽  
Predictive Equations ◽  
Mean Values ◽  
Wide Range ◽  
Three Body

AbstractObjectiveTo cross-validate three predictive set of equations for basal metabolic rate (BMR) developed by Schofield (Schofield database), Henry (Oxford database) and Cole (Oxford database) using mean values for age, weight, height and BMR of published studies.DesignLiterature review of studies published from 1985 to March 2002.SettingAll studies selected used appropriate methods and followed conditions that met the criteria established for basal metabolism, were performed in healthy adults, and were not part of the Schofield or Oxford database.SubjectsA total of 261 groups of men and women from 175 studies were selected and categorised in three age groups (18.5–29.9, 30.0–59.9, ≥60 years old) and three body mass index (BMI) groups (normal weight, overweight and obese).ResultsLinear regression and concordance correlation analysis showed that the three sets of equations had the same association and agreement with measured BMR, across gender, age, and BMI groups. The agreement of all equations was moderate for men and poor for women. The lowest mean squared prediction errors (MSPRs) were given by Henry equations in men and Cole equations in women. Henry and Cole equations gave lower values than Schofield equations, except for men over 60 years of age. Henry equations were the most accurate in men. None of the three equations performed consistently better in women.ConclusionThese results support the use of Henry equations in men with a wide range of age and BMI. None of the proposed predictive equations seem to be appropriate to estimate BMR in women.

scholarly journals Transient cold nodule of the thyroid due to localized postpartum thyroiditis

1998 ◽  
pp. 562-564 ◽  
Author(s):  
R Luboshitzky ◽  
G Qupti ◽  
A Ishai ◽  
M Dharan
Keyword(s):  
Thyroid Nodule ◽  
Thyroid Function ◽  
Needle Aspiration ◽  
Thyroid Function Tests ◽  
Thyroid Scintigraphy ◽  
Postpartum Thyroiditis ◽  
Normal Thyroid Function ◽  
Function Tests ◽  
Needle Aspiration Cytology ◽  
Cold Nodule

A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymphocytes, suggesting lymphocytic thyroiditis. Thyroid function tests were normal and thyroid autoantibodies were negative. After two months the thyroid nodule was not palpated and thyroid scintigraphy returned to normal. Thyroid function tests remained normal twelve months after delivery. These findings suggest that postpartum thyroiditis may present as a localized transient form and should be considered in the differential diagnosis of painless solitary nodule that appears postpartum.

scholarly journals Enlarged Thyroid Gland with Normal Thyroid Function Tests

2008 ◽  
Vol 21 (2) ◽  
pp. 179-182
Author(s):  
Carol F. Adair ◽  
John T. Preskitt ◽  
Kristin L. Joyner ◽  
Robin W. Dobson
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Function Tests ◽  
Normal Thyroid ◽  
Normal Thyroid Function ◽  
Function Tests

scholarly journals Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A841-A841
Author(s):  
Alessandro Brancatella ◽  
Isabella Lupi ◽  
Lucia Montanelli ◽  
Debora Ricci ◽  
Nicola Viola ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Checkpoint Inhibitors ◽  
Thyroid Volume ◽  
Clinical Severity ◽  
Response To Treatment ◽  
Thyroid Function Tests ◽  
Thyroid Ultrasound ◽  
Normal Thyroid ◽  
Normal Thyroid Function

Abstract Context: Thyrotoxicosis is a common immune-related adverse event in patients treated with PD1 or PD-L1 checkpoint inhibitors. A detailed endocrinological assessment, including thyroid ultrasound and scintigraphy is missing, as are data on response to treatment and follow-up. Objectives: To better characterize the thyrotoxicosis secondary to immune checkpoint inhibitors, gaining insights into pathogenesis and informing management. Methods: We conducted a prospective cohort study of 20 consecutive patients who had normal thyroid function before starting immunotherapy and then experienced thyrotoxicosis upon PD1 or PD-L1 blockade. Clinical assessment was combined with thyroid ultrasound, scintigraphy, and longitudinal thyroid function tests. Results: Five patients had normal scintigraphic uptake (Sci+), no serum antibodies against the TSH receptor, and remained hyperthyroid throughout follow-up. The other 15 patients had no scintigraphic uptake (Sci-) and experienced destructive thyrotoxicosis followed by hypothyroidism (N= 9) or euthyroidism (N= 6). Hypothyroidism was more readily seen in those with normal thyroid volume than in those with goiter (P= 0.04). Among Sci- subjects, a larger thyroid volume was associated to a longer time to remission (P<0.05). Methimazole (MMI) was effective only in Sci+ subjects (P<0.05). Conclusions: Administration of PD1 or PD-L1 blocking antibodies may induce two different forms of thyrotoxicosis that appear similar in clinical severity at onset: a type 1 characterized by persistent hyperthyroidism that requires treatment with MMI, and a type 2 characterized by destructive and transient thyrotoxicosis that evolves to hypo- or eu-thyroidism. Thyroid scintigraphy and ultrasound help differentiating and managing these two forms of iatrogenic thyrotoxicosis

scholarly journals Basal Metabolic Rate of Adolescent Modern Pentathlon Athletes: Agreement between Indirect Calorimetry and Predictive Equations and the Correlation with Body Parameters

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142859 ◽  
Author(s):  
Luiz Lannes Loureiro ◽  
Sidnei Fonseca ◽  
Natalia Gomes Casanova de Oliveira e Castro ◽  
Renata Baratta dos Passos ◽  
Cristiana Pedrosa Melo Porto ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Indirect Calorimetry ◽  
Predictive Equations ◽  
Body Parameters

scholarly journals ENDOCRINOLOGY IN PREGNANCY: Pregnancy and the incidence, diagnosing and therapy of Graves’ disease

2016 ◽  
Vol 175 (5) ◽  
pp. R219-R230 ◽  
Author(s):  
Peter Laurberg ◽  
Stine Linding Andersen
Keyword(s):  
Thyroid Function ◽  
Birth Defects ◽  
Early Pregnancy ◽  
Graves Disease ◽  
Thyroid Function Tests ◽  
Developmental Factors ◽  
Normal Thyroid Function ◽  
Important Concern ◽  
And Control ◽  
In Pregnancy

Thyroid hormones are essential developmental factors, and Graves’ disease (GD) may severely complicate a pregnancy. This review describes how pregnancy changes the risk of developing GD, how early pregnancy by several mechanisms leads to considerable changes in the results of the thyroid function tests used to diagnose hyperthyroidism, and how these changes may complicate the diagnosing of GD. Standard therapy of GD in pregnancy is anti-thyroid drugs. However, new studies have shown considerable risk of birth defects if these drugs are used in specific weeks of early pregnancy, and this should be taken into consideration when planning therapy and control of women who may in the future become pregnant. Early pregnancy is a period of major focus in GD, where pregnancy should be diagnosed as soon as possible, and where important and instant change in therapy may be warranted. Such change may be an immediate stop of anti-thyroid drug therapy in patients with a low risk of rapid relapse of hyperthyroidism, or it may be an immediate shift from methimazole/carbimazole (with risk of severe birth defects) to propylthiouracil (with less risk), or maybe to other types of therapy where no risk of birth defects have been observed. In the second half of pregnancy, an important concern is that not only the mother with GD but also her foetus should have normal thyroid function.

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