A case of upper extremity deep vein thrombosis due to Kikuchi Fujimoto disease

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 371-374
Author(s):  
Belaj ◽  
Gary ◽  
Eller ◽  
Deutschmann ◽  
Beham-Schmid ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Upper Extremity ◽  
Lupus Erythematosus ◽  
Lymph Node Biopsy ◽  
Vein Thrombosis ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Systemic Symptoms ◽  
Deep Vein

Kikuchi Fujimoto disease (KFD) is a rare form of lymphadeopathy with systemic symptoms. We present a case of a 31-year-old female farmer who was admitted to the emergency ward because of swelling of the left arm. Upper extremity venous thrombosis due to local compression of lymph nodes was diagnosed. The histological workup of lymph node biopsy showed histiocytic necrotizing lymphadenitis which is a typical sign of KFD. Anticoagulant treatment for the venous thrombosis was initiated. As KFD is often associated with a transition to systemic lupus erythematosus follow up visits are scheduled in our outpatient clinic.

Long-term follow-up of patients with suspected deep vein thrombosis of the upper extremity: survival, risk factors and post-thrombotic syndrome

2004 ◽  
Vol 15 (8) ◽  
pp. 503-507 ◽  
Author(s):  
Henk J. Baarslag ◽  
Maria M.W. Koopman ◽  
Barbara A. Hutten ◽  
May W. Linthorst Homan ◽  
Harry R. Büller ◽  
...  
Keyword(s):  
Risk Factors ◽  
Deep Vein Thrombosis ◽  
Upper Extremity ◽  
Vein Thrombosis ◽  
Post Thrombotic Syndrome ◽  
Long Term Follow Up ◽  
Survival Risk ◽  
Deep Vein

scholarly journals Upper extremity deep vein thrombosis in an informal porter

2020 ◽  
Vol 39 (3) ◽  
pp. 207
Author(s):  
Dewi S. Soemarko ◽  
Herlinah Herlinah
Keyword(s):  
Deep Vein Thrombosis ◽  
Upper Extremity ◽  
Rare Condition ◽  
Predisposing Factor ◽  
Manual Lifting ◽  
Vein Thrombosis ◽  
Medicine Physician ◽  
The Right ◽  
Deep Vein

Background<br />Upper extremity deep vein thrombosis (UEDVT) is a rare condition, in which job-related arm movements and repetitive, forceful or overhead arm activities have been recognized as the predisposing factor for this condition. UEDVT can occur among informal porters. This report describes a case of UEDVT in an informal porter due to manual lifting of heavy goods and reviews the literature for occupational reports of this condition.<br /><br />Case description<br />A 35-year-old male informal porter presented with marked swelling, pain, and numbness of his right arm 3 days after a prolonged episode of lifting heavy goods. A Doppler ultrasound showed thrombosis in the right subclavian and axillary veins and laboratory tests found elevated D-dimer. Patient was diagnosed as having axillo-subclavian thrombosis and treated with low molecular-weight heparin. One month after the last follow-up, patient returned to work with modified capacity and after 3 months of return to work, patient was able to resume his regular duties without impairment or disability.<br /><br />Conclusion<br />The occupation of informal porter should be considered a risk factor for upper extremity deep vein thrombosis (UEDVT), thus the occupational medicine physician should be aware of this condition in the context of manual workers. Detailed occupational history to aid the diagnosis and future risk assessment are needed, and education for preventing UEDVT should be provided to porters.

Case of vaso-occlusive retinopathy in Kikuchi-Fujimoto and lupus overlap syndrome

2021 ◽  
Vol 14 (5) ◽  
pp. e240752
Author(s):  
Nima Ghadiri ◽  
Miles Stanford
Keyword(s):  
Lupus Erythematosus ◽  
Disease Process ◽  
Lymph Node Biopsy ◽  
Overlap Syndrome ◽  
Benign Condition ◽  
Appropriate Treatment ◽  
Retinal Microvasculature ◽  
Systemic Symptoms ◽  
Sequential Reduction

A 35-year-old woman presented with a constellation of systemic symptoms: rashes, weight loss, arthralgia and mouth ulcers. Six months afterwards, she experienced bilateral and sequential reduction in vision, and was found to have bilateral vaso-occlusive retinopathy, with critical macular ischaemia in the left eye. Her serological markers were consistent with a diagnosis of lupus. A lymph node biopsy confirmed Kikuchi-Fujimoto disease, a benign condition of unknown cause characterised by fever, cervical and axillary lymphadenopathy. Given that this overlap syndrome was associated with a number of systemic features and had affected the eyes, an immunosuppressive regime with rituximab was considered prudent. This rendered her vasculitis stable and non-progressive, and there were signs of partial retinal microvasculature recovery on optical coherence tomography angiography. There is increasing evidence of an overlap between Kikuchi-Fujimoto disease and systemic lupus erythematosus, which is associated with vaso-occlusive retinopathy. In these instances, a multidisciplinary approach is warranted, with consideration of appropriate treatment in order to prevent harmful sequelae of vasculitis. Our treatment with rituximab abated the disease process, although close follow-up is paramount to monitor results and side-effects of treatment.

Fibrin fragment D-dimer and the risk of future venous thrombosis

Blood ◽  
2003 ◽  
Vol 101 (4) ◽  
pp. 1243-1248 ◽  
Author(s):  
Mary Cushman ◽  
Aaron R. Folsom ◽  
Lu Wang ◽  
Nena Aleksic ◽  
Wayne D. Rosamond ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Factor V Leiden ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Odds Ratios ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
D Dimer

Plasma D-dimer concentration rises more than 100-fold during acute deep vein thrombosis, but there are no prospective data concerning D-dimer as a risk factor for incident venous thrombosis in a general population. Incident venous thrombosis was ascertained in 2 prospective observational studies, the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Of 21 690 participants enrolled between 1987 and 1993, after 8 years of follow-up, D-dimer was measured using baseline stored plasma of 307 participants who developed venous thrombosis and 616 who did not. Relative to the first quintile of the distribution of D-dimer, the age-adjusted odds ratios for future venous thrombosis for the second to fifth quintiles of D-dimer were 1.6, 2.3, 2.3, and 4.2, respectively (P for trend < .0001). Following added adjustment for sex, race, body mass index, factor V Leiden, prothrombin 20210A, and elevated factor VIII coagulant activity (factor VIII:c), these odds ratios were 1.5, 2.1, 1.9, and 3.0, respectively (P for trend < .0001). Among those with idiopathic thrombosis or secondary thrombosis unrelated to cancer, the adjusted fifth quintile odds ratios were 3.5 and 4.8, respectively. By contrast, D-dimer in the fifth versus first quintile was not related to occurrence of cancer-associated thrombosis (odds ratio, 1.1). Odds ratios for elevated D-dimer were consistently elevated in subgroups defined by age, sex, race, duration of follow-up, and thrombosis type (deep vein thrombosis or pulmonary embolus). D-dimer is strongly and positively related to the occurrence of future venous thrombosis.

scholarly journals Apixaban anti-Xa level monitoring in treatment of acute upper extremity deep vein thrombosis for patient on chronic hemodialysis: a case report

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Guillaume Roberge ◽  
Philip Stephen Wells
Keyword(s):  
Deep Vein Thrombosis ◽  
Upper Extremity ◽  
Bleeding Risk ◽  
Chronic Hemodialysis ◽  
Case Presentation ◽  
Vein Thrombosis ◽  
Acute Venous Thromboembolism ◽  
Deep Vein ◽  
Trough Levels

Abstract Background Patients on dialysis are at higher risk of major bleeding and recurrent thrombosis creating acute venous thromboembolism (VTE) treatment challenges. DOACs represent an interesting option but there are concerns of bioaccumulation and increased bleeding risk. Anti-Xa trough levels may be used to monitor for bioaccumulation but there is little data. Case presentation We describe a case, a 51 yo female, 36 kg on hemodialysis with a provoked acute upper extremity deep vein thrombosis in whom body habitus and calciphylaxis contraindicated the use of standard therapy. She received apixaban 2.5 mg twice daily for 6 weeks. The apixaban anti-Xa trough levels were measured weekly 12 h after the morning dose and ranged from 58 to 84 ng/mL, similar to expected levels with normal renal function. There were no adverse events in the 3 months follow-up. Conclusions We saw no evidence of bioaccumulation indicating a potential role for low dose apixaban for acute VTE in dialysis patients.

scholarly journals CEREBRAL SINUS VENOUS THROMBOSIS PADA PENDERITA SYSTEMIC LUPUS ERYTHEMATOSUS

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Destika Fahrina ◽  
Mohammad Arief Rachman Kemal ◽  
Adiel Amaris Syah ◽  
Melita Melita ◽  
Lyna Soertidewi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Venous Thrombosis ◽  
Lupus Erythematosus ◽  
Low Molecular Weight ◽  
Systemic Lupus ◽  
Vein Thrombosis ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Deep Vein ◽  
Sinus Venous Thrombosis

    CEREBRAL SINUS VENOUS THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTABSTRACTCerebral sinus venous thrombosis (CSVT) may sometimes be associated with autoimmune disorder like systemic lupus erythematosus (SLE). It is characterized by dural venous thrombosis which can cause variety of symptoms including headache, convulsion, motor weakness, and decreased level of consciousness. Thrombosis often occurs in the lower extremities in postpartum women due to prolonged bed rest and caesarean section. We reported a 33-year-old woman, who presented with chief complaint of weakness in the left arm and leg, a history of headache and seizures, the following 3 weeks, she had swelling and pain which started at the tip of the left foot then right leg and to the waist. D-dimer level was increased with positive ANA test. Diagnostic investigations include non-contrast head CT scan, CTV, DSA, Doppler ultrasound and thoracoabdominal vasculare CT. Low molecular weight heparin (LMWH) was given for 5 days, continued with oral anticoagulant.Keywords: Cerebral sinus venous thrombosis, deep vein thrombosis, LMWH, postpartum, systemic lupus erythematosusABSTRAKCerebral sinus venous thrombosis (CSVT) dapat berkaitan dengan gangguan autoimun seperti systemic lupus erythematosus (SLE). Hal ini ditandai adanya trombosis vena dural yang menyebabkan berbagai gejala, seperti nyeri kepala, kejang, kelemahan motorik, serta penurunan kesadaran. Trombosis juga sering terjadi di ekstremitas bawah pada perempuan postpartum akibat tirah baring yang lama dan tindakan seksio sesaria. Dilaporkan kasus seorang perempuan 33 tahun dengan keluhan kelemahan tubuh sisi kiri serta riwayat nyeri kepala dan kejang yang 3 minggu kemudian dijumpai bengkak dan nyeri mulai dari ujung kaki kiri kemudian kaki kanan, hingga naik sampai pinggang. Terdapat peningkatan D-dimer dengan tes ANA (+). Pemeriksaan penunjang diagnostik berupa head CT scan nonkontras, CTV, DSA, USG doppler ekstremitas serta CT vascular thoracoabdominal. Pasien diberikan terapi low molecular weight heparin (LMWH) selama 5 hari, dilanjutkan dengan antikoagulan oral.Kata kunci: Cerebral sinus venous thrombosis, deep vein thrombosis, LMWH, postpartum, systemic lupus erythematosus  

Deep Vein Thrombosis in Obstetric Patients: Diagnosis and Risk Factors

1992 ◽  
Vol 67 (01) ◽  
pp. 004-007 ◽  
Author(s):  
Karin de Boer ◽  
Harry R Büller ◽  
Jan W ten Cate ◽  
Marcel Levi
Keyword(s):  
Risk Factors ◽  
Deep Vein Thrombosis ◽  
Venous Thromboembolism ◽  
Venous Thrombosis ◽  
Diagnostic Method ◽  
Clinical Symptoms ◽  
Impedance Plethysmography ◽  
Vein Thrombosis ◽  
Deep Vein

SummaryThis study was performed to assess the prevalence of deep vein thrombosis (DVT) in consecutive obstetric patients with clinical symptoms of DVT, using impedance plethysmography (IPG) as the diagnostic method and to establish the safety of withholding anticoagulant therapy in patients with a repeatedly normal IPG. In addition, in patients with DVT the prevalence of coagulation and fibrinolytic disorders, which may explain the occurrence of venous thrombosis was investigated.Of the 77 obstetric patients with symptoms of DVT 32 (42%) had an abnormal IPG. The remaining 45 patients had a repeatedly normal IPG and showed no venous thromboembolism during a 6 months follow-up period. Twenty percent (six patients) of the patients with an abnormal IPG had a coagulation or fibrinolytic abnormality. These observations suggest that serial IPG can be used effectively in the management of obstetric patients with clinically suspected DVT and that hemostatic abnormalities are frequently found in those patients with DVT

Evaluation of Catheter Directed Thrombolytic Therapy versus Systemic Anticoagulant Therapy of Acute Ilio-Femoral Deep Vein Thrombosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samy Gamil Akhnoukh ◽  
Ramez Monuir Wahba ◽  
Nabil Gamal Abd Elnaser Mahmoud
Keyword(s):  
Deep Vein Thrombosis ◽  
Thrombolytic Therapy ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Anticoagulant Therapy ◽  
Vein Thrombosis ◽  
Phlegmasia Alba ◽  
Venous Gangrene ◽  
Deep Vein

Abstract Background Deep venous thrombosis (DVT) is a major cause of morbidity and mortality all-over the world. Complications include pulmonary embolism (PE), post-thrombotic syndrome (PTS), phlegmasia alba dolens, phlegmasia cerulea dolens and venous gangrene. The PTS is the most common cause of long-term morbidity and disability among the previous complications. Aim of the Work The aim of this work is evaluation of the regional catheter-directed thrombolytic therapy versus standard systemic anticoagulant therapy in cases of acute ilio-femoral deep vein thrombosis as regard to efficacy, safety as well as complications. Patients and Methods This study was conducted on 30 patients presented to the vascular surgery unit of Ahmed Maher Teaching Hospital between February, 2019 and August, 2019 with acute iliofemoral deep venous thrombosis (less than two weeks duration). Of the 30 patients, 18 were females and 12 were males. The age of the patients ranged between 22 and 55 years. Results The outcome results of early Follow up of the thrombolytic therapy was complete recanalization in 30.7% of the cases, partial re-canalization in 53.8% of the cases and poor recanalization in the remaining cases15.3%.While the follow up results of anticoagulant therapy was complete re-canalization in 6.7% of the cases, partial re-canalization in 60% of cases and poor recanalization in the remaining cases 33.3% Conclusion Catheter directed thrombolytic therapy using streptokinase, as a lytic agent in the treatment of acute ilio-femoral DVT is a safe and efficient technique.

scholarly journals UPPER EXTREMITY DEEP VENOUS THROMBOSIS

2021 ◽  
Vol 14 (3) ◽  
Author(s):  
A Venkatesh ◽  
V Nanda ◽  
B Ramesh
Keyword(s):  
Emergency Department ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Upper Extremity ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Vein Thrombosis ◽  
Patients With Cancer ◽  
Monary Embolism ◽  
Deep Vein

Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pul-monary embolism (PE) and post-thrombotic syndrome (PTS) in the arm. The incidence of secondary UED-VT is increasing due to widespread use of central venous catheters in patients with cancer and other chronic diseases. We report a case of 51-year-old female diagnosed with upper extremity deep venous thrombosis in emergency department with no co-morbidities and its successful treatment.

scholarly journals Upper extremity deep venous thrombosis secondary to thyrotoxic periodic paralysis with accompanying hyperphosphatemia and severe hypomagnesemia

2021 ◽  
Vol 9 (41) ◽  
pp. 47-49
Author(s):  
Jasmin Rahesh ◽  
Layan Al-Sukhni ◽  
Baseer Quraishi ◽  
Tarek Naguib
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Upper Extremity ◽  
Periodic Paralysis ◽  
Central Catheter ◽  
Thyrotoxic Periodic Paralysis ◽  
Vein Thrombosis ◽  
Life Threatening ◽  
Characteristic Features ◽  
Deep Vein

Thyrotoxic periodic paralysis is a rare but life-threatening complication of hyperthyroidism. Characteristic features involve thyrotoxicosis, acute paralysis, and hypokalemia. Mild hypomagnesemia and hypophosphatemia are also present in most cases due to the resulting transcellular shift of electrolytes. Complications of thyrotoxic periodic paralysis reported in the literature have included cerebral venous thrombosis as well as lower extremity deep venous thrombosis. We present a patient with an unusual presentation of thyrotoxic periodic paralysis as reflected by hyperphosphatemia, upper extremity deep venous thrombosis and severe hypomagnesemia. This is the first reported case of upper extremity deep vein thrombosis in association with a peripherally inserted central catheter line secondary to thyrotoxicosis.

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