Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Cerebrovascular Disease Without Dementia

2008 ◽  
Vol 22 (1) ◽  
pp. 14-19 ◽  
Author(s):  
S. Sedlackova ◽  
I. Rektorova ◽  
Z. Fanfrdlova ◽  
I. Rektor
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Specific Effect ◽  
Frameless Stereotaxy ◽  
Stimulation Site ◽  
Positive Effects ◽  
Vascular Type ◽  
Low Frequency Rtms

Aims: The results of our pilot study suggested that one session of high frequency rTMS applied over the left dorsolateral prefrontal cortex (DLPFC) might induce measurable positive effects on executive functioning in patients with mild cognitive impairment of the vascular type without dementia (MCI-V). The aims of the current study were to replicate the results of our pilot study using a frameless stereotaxy as opposed to the standard and routinely used procedure. We also studied the effects of low frequency rTMS. Patients and method: Seven patients with MCI-V participated in a randomized, controlled, blind study with a crossover design. Each patient received 10 Hz and 1 Hz stimulation over the left DLPFC (an active stimulation site) or the motor cortex (MC; a control stimulation site). Frameless stereotaxy was used to target the DLPFC. The order of sites and frequencies was randomized. A short battery of neuropsychological tests was performed to evaluate executive function, working memory, and psychomotor speed. Results: One session of both high and low frequency rTMS was well tolerated and safe in terms of the cognitive after-effects in patients with MCI-V. We did not observe any significant frequency dependent or stimulation site-dependent cognitive effects of rTMS. Conclusion: We found neither positive nor negative significant effect of either low or high frequency rTMS applied over the DLPFC or the MC, while a mild positive site-specific effect of 10 Hz rTMS was observed in our pilot study on the Stroop interference results. These results suggested that MCI-V is a heterogeneous and poorly defined entity and, thus, rTMS might be useful in a subpopulation of this group of patients.

The effects of different frequencies of repetitive transcranial magnetic stimulation (rTMS) on intracranial neurotransmitters in patients with swallowing disorders after cerebral infarction

2019 ◽  
Author(s):  
Yupeng Du ◽  
Li Wei ◽  
Huangwei Jiang
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Cerebral Infarction ◽  
Test Scores ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Swallowing Disorders ◽  
Control Group ◽  
Low Frequency Rtms

Abstract Objective To study the improvements and mechanism of repetitive transcranial magnetic stimulation (rTMS) on swallowing disorders after cerebral infarction. Methods A total of 60 patients with swallowing disorders were randomly assigned to receive high/low-frequency rTMS treatment, another 30 patients without rTMS treatment were included in the control group. The Kubota’s water-swallowing test, video fluoroscopic swallowing study (VFSS), and major intracranial neurotransmitters were analyzed before and after treatment. Results No significant difference was observed in the Kubota’s water-swallowing test scores, the VFSS scores, or the levels of intracranial neurotransmitters between the three groups before treatment. The Kubota’s water-swallowing test scores were significantly reduced after high-frequency rTMS treatment than in the control group; the aspiration degree was significantly increased after high-frequency rTMS treatment than in the control group; the levels of glutamate and dopamine were significantly increased after high-frequency rTMS treatment than in the control group; Moreover, the Kubota’s water-swallowing test scores were significantly reduced after high-frequency rTMS treatment than after low-frequency rTMS treatment; the levels of glutamate and dopamine were significantly increased after high-frequency rTMS treatment than after low-frequency rTMS treatment. Conclusions High-frequency rTMS was effective for swallowing disorders, which may be related to increased levels of intracranial glutamate and dopamine.

Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study

2020 ◽  
Vol 32 (6) ◽  
pp. 328-338
Author(s):  
Poul Erik Buchholtz ◽  
Mahmoud Ashkanian ◽  
Simon Hjerrild ◽  
Line Kirstine Hauptmann ◽  
Torben Albert Devantier ◽  
...  
Keyword(s):  
Placebo Group ◽  
Pilot Study ◽  
Major Depression ◽  
Negative Impact ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Double Blind Study ◽  
Depressant Effect ◽  
Significant Difference ◽  
Low Frequency Rtms

AbstractObjective:Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.Methods:In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.

TMS in Tinnitus Treatment: Enhancement by Dopamine Agonists?

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P61-P61
Author(s):  
Tobias Kleinjung ◽  
Veronika Vielsmeier ◽  
Michael Landgrebe ◽  
Thomas Steffens ◽  
Juergen Strutz ◽  
...  
Keyword(s):  
Dopamine Agonists ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Statistical Significance ◽  
Temporal Cortex ◽  
Low Frequency ◽  
Chronic Tinnitus ◽  
Control Group ◽  
Clinical Effects ◽  
Positive Effects ◽  
Low Frequency Rtms

Objective Repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex revealed positive effects in patients with chronic tinnitus. Recent preclinical data in healthy controls suggest that effects of low frequency rTMS can be enhanced by application of dopamine agonists. Based on these data, we investigated whether application of a dopaminergic drug increases clinical effects of low frequency rTMS over the auditory cortex in tinnitus patients. Methods 18 subjects with chronic tinnitus received sessions of 1Hz rTMS (2000 pulses/d, 110% motor threshold) applied to the left temporal cortex on 10 subsequent working days. Additionally, these subjects received one dosage of Madopar® (100mg Levodopa/ 25 mg Benserazide)1 hour prior to each TMS session. Treatment outcome was assessed over a 3-month period with a tinnitus questionnaire (TQ). Treatment effects were compared to a control group matched for age, gender, tinnitus duration, and hearing loss, which received the same rTMS treatment without prior Levodopa application. Results TMS treatment resulted in a reduction of TQ scores in both groups. Improvement was slightly superior in the Levodopa group, but the difference did not reach statistical significance (p <0.05). Conclusions These results further support that rTMS has beneficial effects in treatment of chronic tinnitus. Levodopa resulted in a slight, but non-significant, tendency towards better outcome. Further studies with larger sample sizes are needed.

scholarly journals Individualized Responses to Ipsilesional High-Frequency and Contralesional Low-Frequency rTMS in Chronic Stroke: A Pilot Study to Support the Individualization of Neuromodulation for Rehabilitation

2020 ◽  
Vol 14 ◽  
Author(s):  
John Harvey Kindred ◽  
Elizabeth Carr Wonsetler ◽  
Charalambos Costas Charalambous ◽  
Shraddha Srivastava ◽  
Barbara Khalibinzwa Marebwa ◽  
...  
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Low Frequency ◽  
Chronic Stroke ◽  
Low Frequency Rtms

scholarly journals Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Teresa Leao ◽  
Kathrin Machetanz ◽  
Joey Sandritter ◽  
Marina Liebsch ◽  
Andreas Stengel ◽  
...  
Keyword(s):  
Pilot Study ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Acute Effect ◽  
Term Effect ◽  
Long Term Effect ◽  
The Right ◽  
Low Frequency Rtms ◽  
Present Pilot Study

Background: Vestibular schwannomas (VS) are brain tumors affecting the vestibulocochlear nerve. Thus, VS patients suffer from tinnitus (TN). While the pathophysiology is mainly unclear, there is an increasing interest in repetitive transcranial magnetic stimulation (rTMS) for TN treatment. However, the results have been divergent. In addition to the methodological aspects, the heterogeneity of the patients might affect the outcome. Yet, there is no study evaluating rTMS exclusively in VS-associated tinnitus. Thus, the present pilot study evaluates low-frequency rTMS to the right dorsolateral pre-frontal cortex (DLPFC) in a VS-associated tinnitus.Methods: This prospective pilot study enrolled nine patients with a monoaural VS-associated tinnitus ipsilateral to the tumor. Patients were treated with a 10-day rTMS regime (1 Hz, 100% RMT, 1,200 pulses, right DLPFC). The primary endpoint of the study was the reduction of TN distress (according to the Tinnitus Handicap Inventory, THI). The secondary endpoint was a reduction of TN intensity (according to the Tinnitus Matching Test, TMT) and the evaluation of factors predicting tinnitus outcome (i.e., hearing impairment, TN duration, type of tinnitus).Results: No complications or side effects occurred. There was one drop-out due to a non-responsiveness of the complaint. There was a significant acute effect of rTMS on the THI and TMT. However, there was no significant long-term effect after 4 weeks. While the THI failed to detect any clinically relevant acute effect of rTMS in 56% of the patients, TMT revealed a reduction of TN intensity for more than 20 in 89% and for more than 50 in 56% of the patients. Notably, the acute effect of rTMS was influenced by the TN type and duration. In general, patients with a tonal TN and shorter TN duration showed a better response to the rTMS therapy.Conclusion: The present pilot study is the first one to exclusively evaluate the effect of low-frequency rTMS to the right DLPFC in a VS-associated tinnitus. Our results prove the feasibility and the efficacy of rTMS in this patient cohort. There is a significant acute but a limited long-term effect. In addition, there is evidence that patients with a tonal tinnitus and shorter tinnitus duration might have the strongest benefit. A larger, randomized controlled study is necessary to prove these initial findings.

High-frequency priming stimulation does not enhance the effect of low-frequency rTMS in the treatment of tinnitus

2007 ◽  
Vol 184 (4) ◽  
pp. 587-591 ◽  
Author(s):  
Berthold Langguth ◽  
Tobias Kleinjung ◽  
Elmar Frank ◽  
Michael Landgrebe ◽  
Philipp Sand ◽  
...  
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
Low Frequency Rtms

Naturalistic Study of the use of Transcranial Magnetic Stimulation in the Treatment of Depressive Relapse

2006 ◽  
Vol 40 (9) ◽  
pp. 764-768 ◽  
Author(s):  
Paul B. Fitzgerald ◽  
Jessica Benitez ◽  
Anthony R. De Castella ◽  
Timothy L. Brown ◽  
Z. Jeff Daskalakis ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Naturalistic Study ◽  
Treatment Of Depression ◽  
Long Term Impact ◽  
Over Time

Background: The efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression has been assessed in a number of acute treatment trials during the last 10 years. Little is known about the long-term impact of the treatment on the disorder and its effectiveness when applied for repeated relapses of depression over time. Method: Nineteen patients who had previously responded to rTMS in clinical trials received treatment with rTMS for a total of 30 episodes of depressive relapse. Results: Approximately 10 months elapsed between treatment episodes. The majority of patients achieved a significant improvement in each treatment course with significant improvements achieved in patients treated with both low-frequency right-sided rTMS and high-frequency left-sided rTMS. Conclusions: The study suggests that rTMS may have value in the treatment of episodes of depressive relapse with little reduction in efficacy over time.

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