Forced oscillation total respiratory resistance and spontaneous breathing lung resistance in COPD patients

1999 ◽  
Vol 14 (1) ◽  
pp. 172 ◽  
Author(s):  
R. Farré ◽  
R. Peslin ◽  
M. Rotger ◽  
J Barberá ◽  
D Navajas
1990 ◽  
Vol 69 (4) ◽  
pp. 1372-1379 ◽  
Author(s):  
D. Navajas ◽  
R. Farre ◽  
J. Canet ◽  
M. Rotger ◽  
J. Sanchis

Respiratory impedance (Zrs) was measured between 0.25 and 32 Hz in seven anesthetized and paralyzed patients by applying forced oscillation of low amplitude at the inlet of the endotracheal tube. Effective respiratory resistance (Rrs; in cmH2O.l-1.s) fell sharply from 6.2 +/- 2.1 (SD) at 0.25 Hz to 2.3 +/- 0.6 at 2 Hz. From then on, Rrs decreased slightly with frequency down to 1.5 +/- 0.5 at 32 Hz. Respiratory reactance (Xrs; in cmH2O.l-1.s) was -22.2 +/- 5.9 at 0.25 Hz and reached zero at approximately 14 Hz and 2.3 +/- 0.8 at 32 Hz. Effective respiratory elastance (Ers = -2pi x frequency x Xrs; in cmH2O/1) was 34.8 +/- 9.2 at 0.25 Hz and increased markedly with frequency up to 44.2 +/- 8.6 at 2 Hz. We interpreted Zrs data in terms of a T network mechanical model. We represented the proximal branch by central airway resistance and inertance. The shunt pathway accounted for bronchial distensibility and alveolar gas compressibility. The distal branch included a Newtonian resistance component for tissues and peripheral airways and a viscoelastic component for tissues. When the viscoelastic component was represented by a Kelvin body as in the model of Bates et al. (J. Appl. Physiol. 61: 873-880, 1986), a good fit was obtained over the entire frequency range, and reasonable values of parameters were estimated. The strong frequency dependence of Rrs and Ers observed below 2 Hz in our anesthetized paralyzed patients could be mainly interpreted in terms of tissue viscoelasticity. Nevertheless, the high Ers we found with low volume excursions suggests that tissues also exhibit plasticlike properties.


1977 ◽  
Vol 43 (2) ◽  
pp. 322-330 ◽  
Author(s):  
M. J. Tsai ◽  
R. L. Pimmel ◽  
E. J. Stiff ◽  
P. A. Bromberg ◽  
R. L. Hamlin

The frequency dependency of the magnitude and phase angle of total respiratory impedance was measured in apneic dogs at functional residual capacity during forced oscillation by a special electronics unit. Regression analysis of these data yielded estimates of total respiratory resistance (RFO), inertance (IFO), and compliance (CFO). After correcting for the effects of the endotracheal tube, mean control values (+/-SE) of RFO, IFO, and CFO for the clinically normal dogs were 1.30+/-0.10 cmH2O–1–1-s, 0.0114+/-0.0022 cmH2O–1–1-s2, and 0.0306+/-0.0009 1-cm H2O–1, respectively. Estimates obtained with added resistance, a less dense gas, and abdominal weighting were consistent with predicted effects. In four dogs with mild respiratory symptoms, mean RFO was significantly elevated with no change in IFO or CFO. Independent measurements of resistance and compliance during tidal ventilation correlated well with RFO (r=0.87) and CFO (r=0.80), but RFO and CFO were, on the average, 71% of the tidal breathing values. Thus, the method provides precise estimates of RFO, IFO, and CFO, and allows detection of small changes in these parameters.


1985 ◽  
Vol 58 (4) ◽  
pp. 1164-1169 ◽  
Author(s):  
K. Sekizawa ◽  
H. Sasaki ◽  
T. Takishima

Laryngeal resistance (Rla) in the postpanting interval (PPRla) was examined in five normal subjects in the control state and with methacholine- and histamine-induced bronchoconstriction. Respiratory resistance (Rrs) was measured by the forced oscillation technique at 10 Hz, and Rla was measured by the low-frequency sound method (Sekizawa, K., C. Shindoh, W. Hida, S. Suzuki, et al. J. Appl. Physiol. 55:591–597, 1983). Inspiratory Rrs (IRrs) was lower than expiratory Rrs (ERrs), and Rrs immediately after panting (PPRrs) was not significantly different from IRrs in the three airway conditions. Rla increased with bronchoconstriction and inspiratory Rla (IRla) was lower than expiratory Rla (ERla). PPRla was lower than IRla (P less than 0.01) by an amount corresponding to the decrease in Rrs in the control airway. However, in constricted airways, PPRla was higher than IRla and about the same as ERla. We suggest that the panting maneuver is suitable for minimizing the effect of laryngeal artifact in the control airway, but in the constricted airway the panting maneuver may fail to cause widening of the laryngeal orifice.


2015 ◽  
Vol 46 (6) ◽  
pp. 1672-1679 ◽  
Author(s):  
Kathryn A. Ramsey ◽  
Sarath C. Ranganathan ◽  
Catherine L. Gangell ◽  
Lidija Turkovic ◽  
Judy Park ◽  
...  

This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3–6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease.


1986 ◽  
Vol 71 (s15) ◽  
pp. 8P-9P
Author(s):  
J.E. Neild ◽  
C.H.C. Twort ◽  
S. Chinn ◽  
S. McCormack ◽  
P.G.J. Burney ◽  
...  

1996 ◽  
Vol 80 (4) ◽  
pp. 1105-1111 ◽  
Author(s):  
L. Beydon ◽  
P. Malassine ◽  
A. M. Lorino ◽  
C. Mariette ◽  
F. Bonnet ◽  
...  

Measurement of respiratory impedance by the forced oscillation technique (FOT) in intubated patients requires corrections for the flow-dependent resistance, inertance, and air compression inside the endotracheal tube (ETT). Recently, we published a method to correct respiratory impedance for the mechanical contribution of the ETT. To validate this correction, we compared the respiratory resistance obtained with this method (Rfo) to the intrinsic (Rmin) and total resistances (RT) measured by the airway-occlusion technique (OCT) in 16 intubated sedated paralyzed ventilated patients. The FOT was applied at functional residual capacity in the 4- to 32-Hz frequency range, whereas the OCT was performed at the end of a normal constant-flow inspiration. Rmin corrected with Rfo measured at 16 and 32 Hz [Rfo(16) = 1.10 x Rmin + 0.10 cmH2O.s.l-1, r = 0.96, P < 0.001; Rfo(32) = 0.93 x Rmin + 0.72 cmH2O.s.l-1, r = 0.97, P < 0.001]. RT corrected with Rfo at 4 Hz [Rfo(4) = 1.11 x RT - 1.48 cmH2O.s.l-1; = 0.92; P < 0.001]. We conclude that the FOT improved by correction for the behavior of the ETT is in good agreement with the OCT in intubated patients.


2021 ◽  
Vol 99 (11) ◽  
pp. 43-46
Author(s):  
E. M. Zhukovа ◽  
L. G. Vokhminovа

Clinical testing of the forced oscillation test (FOT) yielded criteria for bronchial obstruction: an increase in viscous respiratory resistance (VRR) (Rfo, Rin, Rex); the frequency dependence of VRR. The study of VRR promoted detection of bronchial malpatency in additional 20% of pulmonary tuberculosis patients who had no lung ventilation disorders, as evidenced by spirometry.


1975 ◽  
Vol 39 (2) ◽  
pp. 305-311 ◽  
Author(s):  
D. C. Stanescu ◽  
R. Fesler ◽  
C. Veriter ◽  
A. Fans ◽  
L. Brasseur

We have modified the measurements of the resistance of the respiratory system, Rrs, by the forced oscillation technique and we have developed equipment to automatically compute Rrs. Flow rate and mouth pressure are treated by selective averaging filters that remove the interference of the subject's respiratory flow on the imposed oscillations. The filtered mean Rrs represents a weighted ensemble average computer over both inspiration and expiration. This method avoids aberrant Rrs values, decreases the variability, and yields an unbiased mean Rrs. Rrs may be measured during slow or rapid spontaneous breathing, in normals and in obstructive patients, over a range of 3–9 Hz. A good reproducibility of Rrs at several days' interval was demonstrated. Frequency dependence of Rrs was found in patients with obstructive lung disease but not in healthy nonsmokers.


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