Canonization, the process by which the Catholic Church names saints, may be fundamentally about holiness, but it is never only about holiness. In the United States, it was often about the ways in which Catholics defined, defended, and celebrated their identities as Americans. This book traces saint-seeking in the United States from the 1880s, the decade in which U.S. Catholics nominated their first candidates for canonization, to 2015, the year Pope Francis named the twelfth American saint in the first such ceremony held on U.S. soil. It argues that U.S. Catholics’ search for a saint of their own sprung from a desire to persuade the Vatican to recognize their country’s holy heroes. But Rome was not U.S. saint-seekers only audience. For the U.S. Catholic faithful, saints served not only as mediators between heaven and earth, but also between the faith they professed and the American culture in which they lived. This panoramic view of American sanctity, focused on figures at the nexus of holiness and U.S. history, this book explores U.S. Catholics’ understanding of themselves both as members of the church and as citizens of the nation—and reveals how those identities converged, diverged, and changed over time.