A continuous source reinstatement model of true and false recollection.

Author(s):  
Brendan T. Johns ◽  
Michael N. Jones ◽  
Douglas J. K. Mewhort
Keyword(s):  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenbin Wei ◽  
Jessica L. Faubel ◽  
Hemaa Selvakumar ◽  
Daniel T. Kovari ◽  
Joanna Tsao ◽  
...  

AbstractTailoring interfaces with polymer brushes is a commonly used strategy to create functional materials for numerous applications. Existing methods are limited in brush thickness, the ability to generate high-density brushes of biopolymers, and the potential for regeneration. Here we introduce a scheme to synthesize ultra-thick regenerating hyaluronan polymer brushes using hyaluronan synthase. The platform provides a dynamic interface with tunable brush heights that extend up to 20 microns – two orders of magnitude thicker than standard brushes. The brushes are easily sculpted into micropatterned landscapes by photo-deactivation of the enzyme. Further, they provide a continuous source of megadalton hyaluronan or they can be covalently-stabilized to the surface. Stabilized brushes exhibit superb resistance to biofilms, yet are locally digested by fibroblasts. This brush technology provides opportunities in a range of arenas including regenerating tailorable biointerfaces for implants, wound healing or lubrication as well as fundamental studies of the glycocalyx and polymer physics.


2021 ◽  
Vol 23 (1) ◽  
pp. 7-27
Author(s):  
Peter Kjær Willendrup ◽  
Kim Lefmann

A key element of the success of McStas is the component layer where users and developers alike are contributing to the description of new physical models and features. In McStas, components realise all physical elements of the simulated instrument from source via optics and samples to detector. In this second review paper of the McStas package, we present an overview of the component classes in McStas: sources, monitors, optics, samples, misc, and contrib. Within each component class we give thorough examples of high-quality components, including their algorithms and example use. We present two example instruments, one for a continuous source and one for a time-of-flight source, that together demonstrate the use of the main component classes. Finally, we give tips and instructions that will allow the reader to write good components and elucidate the pathway of contributing new components to McStas.


2008 ◽  
Vol 8 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Esther K. Chung ◽  
Leny Mathew ◽  
Kelly F. McCollum ◽  
Irma T. Elo ◽  
Jennifer F. Culhane

1938 ◽  
Vol 11 (4) ◽  
pp. 722-727
Author(s):  
L. M. Freeman

Abstract Since the introduction of the oxygen pressure-aging test by Bierer and Davis, prevailing standard conditions for the test have been 70° C. (158° F.) and 300 pounds per square inch oxygen pressure. Various types of equipment have been used; usually the equipment has consisted of a pressure vessel immersed in a constant-temperature water bath to which is connected an oxygen supply. In the majority of instances the equipment has been difficult to operate and maintain for several reasons: Immersion of pressure vessels in a water bath made handling difficult. Corrosion was a continuous source of trouble, causing “freezing” of cover bolts and making it difficult to obtain a leakproof oxygen seal between cover and vessel. This caused loss of oxygen. Each time the pressure vessel was removed from the bath it was necessary to disconnect the oxygen supply and make the connection again when the test was started. This also caused loss of oxygen. If more than one pressure vessel was connected to the oxygen supply and a safety released, the entire oxygen supply was exhausted. The original pressure vessels were relatively large. Since the use of age resistors on a large scale, smaller units have been desirable in order to decrease migration of age resistors and eliminate erroneous results. Some of these operation difficulties were outlined by Ingmanson and Kemp, who also emphasized the importance of temperature control to obtain reproducible results. It is the purpose of this paper to describe an improved oxygen pressure installation which avoids some of these difficulties.


Author(s):  
Vladimír Kompiš ◽  
Mário Štiavnický ◽  
Marián Kompiš ◽  
Zuzana Murčinková ◽  
Qing-Hua Qin
Keyword(s):  

2020 ◽  
Author(s):  
Hiroko Nomaru ◽  
Yang Liu ◽  
Christopher De Bono ◽  
Dario Righelli ◽  
Andrea Cirino ◽  
...  

AbstractThe poles of the heart and branchiomeric muscles of the face and neck are formed from the cardiopharyngeal mesoderm (CPM) within the pharyngeal apparatus. The formation of the cardiac outflow tract and branchiomeric muscles are disrupted in patients with 22q11.2 deletion syndrome (22q11.2DS), due to haploinsufficiency of TBX1, encoding a T-box transcription factor. Here, using single cell RNA-sequencing, we identified a multilineage primed population (MLP) within the CPM, marked by the Tbx1 lineage, which has bipotent properties to form cardiac and skeletal muscle cells. The MLPs are localized within the nascent mesoderm of the caudal lateral pharyngeal apparatus and provide a continuous source of progenitors that undergo TBX1-dependent progression towards maturation. Tbx1 also regulates the balance between MLP maintenance and maturation while restricting ectopic non-mesodermal gene expression. We further show that TBX1 confers this balance by direct regulation of MLP enriched genes and downstream pathways, partly through altering chromatin accessibility. Our study thus uncovers a new cell population and reveals novel mechanisms by which Tbx1 directs the development of the pharyngeal apparatus, which is profoundly altered in 22q11.2DS.


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