This chapter presents a reflection on different policy initiatives targeting multimorbidity. Owing to its global impact on public health, type 2 diabetes is used as an example in this context. Challenges on different levels are illustrated, and the implementation and limitations of scaling-up processes in integrated care initiatives as well as national policies on the prevention of chronic diseases are discussed. Questions on the responsibilities of society, government, and insurance companies to jointly tackle the epidemiologic challenges are addressed and general conclusions on the different approaches are drawn. One important issue significantly hampering the development, implementation, and scaling up of effective policies is the lack of sufficient long-term evaluations. To accomplish sustained improvements of the current public health situation, a strategic shift from individual to shared responsibilities of the different parties is needed. The chapter concludes with proposals for prevention policies and general recommendations for policy development.