scholarly journals 5-Aza-2′-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene

2008 ◽  
Vol 153 (7) ◽  
pp. 1373-1381 ◽  
Author(s):  
H Hagiwara ◽  
H Sato ◽  
Y Ohde ◽  
Y Takano ◽  
T Seki ◽  
...  
Keyword(s):  
Cell Growth ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Xenograft Model ◽  
Connexin 32 ◽  
Human Renal Carcinoma

Assay evaluability of drug testing systems determined with human renal carcinoma cell lines

1984 ◽  
Vol 2 (2) ◽  
pp. 146-155 ◽  
Author(s):  
K. H. Kurth ◽  
J. W. van Dongen ◽  
J. C. Romijn ◽  
M. M. L. Lieber ◽  
F. H. Schröder
Keyword(s):  
Cell Lines ◽  
Drug Testing ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Human Renal Carcinoma

scholarly journals Stimulation by cAMP of erythropoietin secretion by an established human renal carcinoma cell line

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1053-1057 ◽  
Author(s):  
JB Sherwood ◽  
ER Burns ◽  
D Shouval
Keyword(s):  
Cell Line ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Phosphodiesterase Inhibitor ◽  
Adenosine Monophosphate ◽  
Carcinoma Cell Line ◽  
Biologically Active ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cell Line

Abstract We used our recently reported stable, transformed human renal carcinoma cell line as a model system to study the role of 3′,5′-adenosine monophosphate (cAMP) in erythropoietin secretion. The erythropoietin produced by these cells is both biologically active and immunologically cross-reactive with purified native human hormone in our radioimmunoassay. Erythropoietin release by these renal carcinoma cells appears to be stimulated by cAMP as well as by the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX). The response to cAMP involves a rapid and enhanced release of hormone, which occurred within 30 minutes of exposure of the cells to the effector and continued for at least 4 hours. Intracellular erythropoietin was higher in the control cultures than in the cells treated with cAMP, suggesting that cAMP stimulates the release of a storage pool of hormone. The ability of cAMP and MIX to elicit the release of erythropoietin suggests that a cAMP-mediated mechanism is involved in the release of this hormone.

Characterization of plasminogen activator from two human renal carcinoma cell lines

1986 ◽  
Vol 126 (3) ◽  
pp. 435-443 ◽  
Author(s):  
Norman F. Nelson ◽  
Witold Cieplak ◽  
Stephen C. Dacus ◽  
Morton D. Prager
Keyword(s):  
Plasminogen Activator ◽  
Cell Lines ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Human Renal Carcinoma
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