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The FDA approves a first farnesyltransferase inhibitor
Nature Reviews Drug Discovery
◽
10.1038/d41573-020-00213-x
◽
2020
◽
Vol 20
(1)
◽
pp. 8-8
Author(s):
Asher Mullard
Keyword(s):
Farnesyltransferase Inhibitor
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References
Phase I Trial and Pharmacokinetics Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas
Yearbook of Oncology
◽
10.1016/s1040-1741(08)70478-0
◽
2007
◽
Vol 2007
◽
pp. 292-293
Author(s):
R.J. Arceci
Keyword(s):
Phase I
◽
Solid Tumors
◽
Phase I Trial
◽
Neurofibromatosis Type
◽
Type I
◽
Neurofibromatosis Type I
◽
Farnesyltransferase Inhibitor
◽
Plexiform Neurofibromas
◽
Pharmacokinetics Study
Download Full-text
Faculty Opinions recommendation of Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1097392.553443
◽
2007
◽
Author(s):
Channing Der
Keyword(s):
Farnesyltransferase Inhibitor
◽
Progeria Syndrome
◽
Hutchinson Gilford Progeria Syndrome
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Faculty Opinions recommendation of A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1108820.564950
◽
2008
◽
Author(s):
Arati Rao
Keyword(s):
Acute Myeloid Leukemia
◽
Myeloid Leukemia
◽
Farnesyltransferase Inhibitor
◽
Acute Myeloid
Download Full-text
Faculty Opinions recommendation of A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.735400596.793558428
◽
2019
◽
Author(s):
Robert Petersen
Keyword(s):
Tau Pathology
◽
Farnesyltransferase Inhibitor
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The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways
Molecular Pharmacology
◽
10.1124/mol.110.063586
◽
2010
◽
Vol 78
(1)
◽
pp. 142-150
◽
Cited By ~ 22
Author(s):
Chun-Ki Kim
◽
Yoon Kyung Choi
◽
Hansoo Lee
◽
Kwon-Soo Ha
◽
Moo-Ho Won
◽
...
Keyword(s):
Vascular Endothelial Growth Factor
◽
Growth Factor
◽
Protein Kinase
◽
Mitogen Activated Protein Kinase
◽
Signal Pathways
◽
Vascular Endothelial
◽
Phosphatidylinositol 3 Kinase
◽
Farnesyltransferase Inhibitor
◽
Mitogen Activated Protein
◽
Endothelial Growth Factor
Download Full-text
Anti-Inflammatory Activity in Vitro and in Vivo of the Protein Farnesyltransferase Inhibitor Tipifarnib
Journal of Pharmacology and Experimental Therapeutics
◽
10.1124/jpet.105.095976
◽
2005
◽
Vol 317
(1)
◽
pp. 53-60
◽
Cited By ~ 28
Author(s):
Xiaohua Xue
◽
Kuei-Tai A. Lai
◽
Jing-Feng Huang
◽
Yin Gu
◽
Lars Karlsson
◽
...
Keyword(s):
Inflammatory Activity
◽
Farnesyltransferase Inhibitor
◽
Protein Farnesyltransferase
◽
Anti Inflammatory
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ChemInform Abstract: TAN-1813, a Novel Ras-Farnesyltransferase Inhibitor Produced by Phoma sp. Taxonomy, Fermentation, Isolation and Biological Activities in vitro and in vivo.
ChemInform
◽
10.1002/chin.200103218
◽
2001
◽
Vol 32
(3)
◽
pp. no-no
Author(s):
Takafumi Ishii
◽
Kozo Hayashi
◽
Tsuneaki Hida
◽
Yasuharu Yamamoto
◽
Yukimasa Nozaki
Keyword(s):
Biological Activities
◽
Farnesyltransferase Inhibitor
◽
Ras Farnesyltransferase
Download Full-text
The Farnesyltransferase Inhibitor Lonafarnib Induces CCAAT/Enhancer-binding Protein Homologous Protein-dependent Expression of Death Receptor 5, Leading to Induction of Apoptosis in Human Cancer Cells
Journal of Biological Chemistry
◽
10.1074/jbc.m611438200
◽
2007
◽
Vol 282
(26)
◽
pp. 18800-18809
◽
Cited By ~ 41
Author(s):
Shi-Yong Sun
◽
Xiangguo Liu
◽
Wei Zou
◽
Ping Yue
◽
Adam I. Marcus
◽
...
Keyword(s):
Cancer Cells
◽
Human Cancer
◽
Binding Protein
◽
Death Receptor
◽
Death Receptor 5
◽
Farnesyltransferase Inhibitor
◽
Human Cancer Cells
◽
Homologous Protein
◽
Enhancer Binding Protein
◽
Induction Of Apoptosis
Download Full-text
Akt-Dependent Antiapoptotic Action of Insulin Is Sensitive to Farnesyltransferase Inhibitor
Biochemistry
◽
10.1021/bi000995y
◽
2000
◽
Vol 39
(41)
◽
pp. 12513-12521
◽
Cited By ~ 15
Author(s):
Doekbae Park
◽
Sanjay K. Pandey
◽
Elena Maksimova
◽
Sutapa Kole
◽
Michel Bernier
Keyword(s):
Farnesyltransferase Inhibitor
Download Full-text
ChemInform Abstract: Synthesis and in vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E.
ChemInform
◽
10.1002/chin.199831212
◽
2010
◽
Vol 29
(31)
◽
pp. no-no
Author(s):
K. HINTERDING
◽
P. HAGENBUCH
◽
J. RETEY
◽
H. WALDMANN
Keyword(s):
Farnesyltransferase Inhibitor
◽
In Vitro Evaluation
◽
Ras Farnesyltransferase
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