scholarly journals Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients

2012 ◽  
Vol 20 (10) ◽  
pp. 1092-1095 ◽  
Author(s):  
Edyta Mądry ◽  
Beata Krasińska ◽  
Sławomira Drzymała-Czyż ◽  
Dorota Sands ◽  
Aleksandra Lisowska ◽  
...  
2021 ◽  
Vol 20 ◽  
pp. S34
Author(s):  
J. Rodman Berlot ◽  
D. Šmigoc Schweiger ◽  
M. Aldeco ◽  
A. Kotnik Pirš ◽  
D. Lepej ◽  
...  

2011 ◽  
Vol 10 ◽  
pp. S78 ◽  
Author(s):  
E. Madry ◽  
A. Lisowska ◽  
A. Minarowska ◽  
B. Oralewska ◽  
D. Sands ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Grace Y. Lam ◽  
Sameer Desai ◽  
Joey Fu ◽  
Xun Yang Hu ◽  
Jiah Jang ◽  
...  

AbstractCystic fibrosis (CF) is a multi-system disease that is characterized by lung disease due to recurrent airway infection and inflammation. Endocrine complications, such as CF bone disease (CFBD), are increasingly identified as patients are living longer. The cause of CFBD is multifactorial with chronic systemic inflammation theorized to be a contributing factor. Thus, we attempted to identify inflammatory biomarkers that are associated with CFBD. We conducted a retrospective observational study of 56 adult patients with CF with an average percentage predictive forced expiratory volume in one second (ppFEV1) of 73.7% (standard deviation: 30.0) who underwent baseline serum analysis for osteoprotegerin (OPG) and pro-inflammatory biomarkers (IL-1β, IL-6, IL-8 and TNF-α), and had repeated dual-energy x-ray absorptiometry (DXA) scans separated by at least 2 years to examine correlations between serum biomarkers and bone mineral density (BMD) measurements. Univariate linear regression model analysis demonstrated that serum IL-1β and IL-8, but not other pro-inflammatory markers, were negatively correlated with baseline BMD results. However, after accounting for confounding variables, only the relationship between IL-8 and left femoral neck BMD remained statistically significant. Additionally, IL-8 level was associated with BMD decline over time. These results suggest that IL-8 might play a unique role in the pathophysiology of CFBD relative to other pro-inflammatory cytokines but further study is warranted before firm conclusions can be made.


2013 ◽  
Vol 2 (2) ◽  
pp. 130-134
Author(s):  
Md. Farid Amanullah ◽  
BP Shrestha ◽  
GP Khanal ◽  
NK Karna ◽  
S Ansari ◽  
...  

Background: Fragility fractures are one of the major health problems. Many factors are associated with it some of which are modifiable and some are not. If we know the value of T-score at which fragility fracture occurs and associated factors responsible for fragility fracture than we will be able to control this burden to the society. The objective of this study is to determine association between fragility fracture and bone mineral density (BMD) using bone densitometry and to know the value of T-score at which fragility fracture occurs. Methods: Patients presenting to B.P. Koirala Institute of Health Sciences with fragility fracture of distal end of radius, fracture around hip and vertebral fractures were included in the study to know the value of T-score at which fragility fracture occurs and their associated risk factor. Patients less than 50 years of age, high energy trauma fracture and pathological fractures were excluded from the study. Results: We found that being multipara, smoking, alcohol consumption, post-hysterectomized patients and steroid intake had significant association with fragility fracture. There was no association with religion, geographic location, associated medical illness, age, sex, associated injury and site of injury. Conclusion: The patients with risk factor for fragility fracture like smoking, alcohol consumption, multipara women, post-hysterectomized women and those who are on long term steroid therapy should undergo BMD test and the value at -3.254 are prone to fragility fracture and should be treated accordingly. Nepal Journal of Medical Sciences | Volume 02 | Number 02 | July-December 2013 | Page 130-134 DOI: http://dx.doi.org/10.3126/njms.v2i2.8956


Bone ◽  
2020 ◽  
Vol 136 ◽  
pp. 115366
Author(s):  
Leen Antonio ◽  
Lærke Priskorn ◽  
Inge A. Olesen ◽  
Jørgen H. Petersen ◽  
Dirk Vanderschueren ◽  
...  

2013 ◽  
Vol 16 (3) ◽  
pp. 28-34 ◽  
Author(s):  
E A Pobel

Analyzed literature data demonstrates the influence of fracture in individuals of different age on the risk of post-traumatic osteopenia and osteoporosis, as well as increase in the risk of the recurrent fractures. It is proved that the fracture leads to a decrease in bone mineral density (BMD) not only in the injured limb, but also other parts of the skeleton. In majority of prospective studies and metaanalysis it was shown that there is no full recovery of BMD after sustained fracture. Posttraumatic osteopenia and osteoporosis increase the risk of re-fracture in the future.


2000 ◽  
Vol 15 (9) ◽  
pp. 1678-1682 ◽  
Author(s):  
Barbara M. Obermayer-Pietsch ◽  
Daniela Walter ◽  
Sabine Kotschan ◽  
Martina Freigassner-Pritz ◽  
R. Windhager ◽  
...  

Bone ◽  
2007 ◽  
Vol 40 (6) ◽  
pp. S61-S62
Author(s):  
O. LOUIS ◽  
K. Toye ◽  
S. Van Biervliet ◽  
I. Gies ◽  
S. Goemare ◽  
...  

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