EPS2.09 F508del genotype is an independent risk factor for reduced bone mineral density in children with cystic fibrosis

2021 ◽  
Vol 20 ◽  
pp. S34
Author(s):  
J. Rodman Berlot ◽  
D. Šmigoc Schweiger ◽  
M. Aldeco ◽  
A. Kotnik Pirš ◽  
D. Lepej ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Risk Factor ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Mineral Density

scholarly journals AB0619 CLINICAL RISK FACTORS, BONE DENSITY AND FALL’S HISTORY AND FRACTURES RELATION: STUDY BY HOSPITAL SURVEY ABOUT 448 CASES

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1344.1-1344
Author(s):  
K. Nassar ◽  
S. Janani
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Risk Factor ◽  
Bone Density ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Past History ◽  
Mineral Density ◽  
History Of

Background:Osteoporosis is a disease that affects bone mineral density (BMD) and bone microarchitecture at the origin of an increased risk of fracture. The reduction in bone density assessed by dual-energy X ray absorptiometry (DXA) and fall history represent the first two risk factors of non-vertebral fracture after menopause. Given the high prevalence of osteoporosis among fallers subjects with common risk factors, causing a surisk of fracture. Several publications including the osteoporosis recommendations indicate DXA in women experienced falls in search of bone fragility may justify a treatment for osteoporosis, especially as the FRAX tool does not include at present the fall of history, an important parameter in the assessment of fracture risk.Objectives:Because of the low attention given to the evaluation of falls’risk, the main objective of the study was to determine the prevalence and the relationship between the past history of fall, reduction of bone mineral density and prevalent fracture.Methods:Transversal and descriptive epidemiological cohort study conducted for 24 months in 448 patients referred by physicians regularly use prescription of BMD. The realization of this exploration by the same DXA-Hologic in the rheumatology department at Ibn Rochd University Hospital was the criterion for entry into the study. All patients were interviewed on the same day on the risk factors for osteoporosis and fractures justifying the prescription of a BMD.Results:Data included 413 women and 35 men. Most women were postmenopausal (89.6%). The average age was 59 years (σ = 13.40), 33.7% were ≥ 65 years. The mean BMI was at 27.50 (σ = 5,2). 18.5% of patients had at least a history of falls in the previous 12 months and 22.5% a history of fracture after a low-energy trauma. 42.9% were osteoporotic and 57.1% had osteopenia in at least one of these sites: lumbar spine, femoral neck, total hip. We did not find significant association between BMD osteoporosis and fall history (p = 0.916). Thus, cases of osteoporosis fractures were not statistically associated with a fall (p = 0.170). Also, the falls were occurring than 18.4% of osteopenic patients (p = 0.220). However, in our study, the fall was an independent risk factor for fracture (p = 0.003) and osteopenic fractures were significantly higher among fallers (p = 0.009 and 0.006 respectively, a drop of history and at least one past fall history).Conclusion:The fall history is a independent risk factor for fracture. This risk is particularly important in case of fragility bone densitometry. The clinical history and fall risk factors should be taken into consideration in the assessment of fracture risk and in the anti-ostoporotique treatment strategy. Thus, the fall seems to be a legitimate indication for DXA and as a parameter to be integrated into the assessment of fracture risk by the FRAX score.References:[1]MH. Edwards, K. Jameson, H. Denison, NC.Harvey, Sayer A. Aihie, EM Dennison, and C Cooper. Clinical risk factors, bone density and fall history in the predection of incident fracture among men and women. Bone. 2013; 52(2): 541–547.Table 1.Multivariate Logistic Regression Results: Adjustment for predictors factors of fallsVariablesOR (95% IC)p-valueAge ≥ 65 ans0,986 (0,412-2,357)0,974Past history of fracture4,271 (1,719-10,611)0,02Walking aid11,214 (2,815-44,670)0,01Vision disturbances8,587 (3,540-20,829)<0,001Rhumatoid arthritis8,047 (2,218-29,192)0,02Diabete3,194 (1,217-8,382)0,018Corticosteroid ≥ 3 mois0,603 (0,156-2,331)0,463Smoking0,241 (0,013-4,518)0,341Ostéopenia (-1 ≤ T-score < -2,5)2,204 (0,875-5,552)0,094Disclosure of Interests:None declared.

scholarly journals Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients

2012 ◽  
Vol 20 (10) ◽  
pp. 1092-1095 ◽  
Author(s):  
Edyta Mądry ◽  
Beata Krasińska ◽  
Sławomira Drzymała-Czyż ◽  
Dorota Sands ◽  
Aleksandra Lisowska ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Risk Factor ◽  
Bone Mineral ◽  
Mineral Density ◽  
Lactose Malabsorption

Hip axis length as an independent risk factor for hip fracture independently of femural bone mineral density in Caucasian elderly Brazilian women

Bone ◽  
2005 ◽  
Vol 37 (6) ◽  
pp. 871-875 ◽  
Author(s):  
Alberto Frisoli ◽  
Ana Patricia Paula ◽  
Marcelo Pinheiro ◽  
Vera Lucia Szejnfeld ◽  
Ronaldo Delmonte Piovezan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Risk Factor ◽  
Hip Fracture ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Mineral Density ◽  
Hip Axis Length ◽  
Axis Length

scholarly journals 309 Lactose intolerance is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis children

2011 ◽  
Vol 10 ◽  
pp. S78 ◽  
Author(s):  
E. Madry ◽  
A. Lisowska ◽  
A. Minarowska ◽  
B. Oralewska ◽  
D. Sands ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Risk Factor ◽  
Bone Mineral ◽  
Lactose Intolerance ◽  
Mineral Density

Low Bone Mineral Density Is an Independent Risk Factor for Stroke and Death

2010 ◽  
Vol 29 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Anna Nordström ◽  
Marie Eriksson ◽  
Birgitta Stegmayr ◽  
Yngve Gustafson ◽  
Peter Nordström
Keyword(s):  
Bone Mineral Density ◽  
Risk Factor ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Mineral Density ◽  
Low Bone Mineral Density

Reconstruction method as an independent risk factor for postoperative bone mineral density loss in gastric cancer

2018 ◽  
Vol 33 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Taisuke Imamura ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Toshiyuki Kosuga ◽  
Takeshi Kubota ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bone Mineral Density ◽  
Risk Factor ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Reconstruction Method ◽  
Mineral Density ◽  
Bone Mineral Density Loss

BONE MINERAL DENSITY (BMD) MEASUREMENT: AN INDEPENDENT RISK FACTOR OF BREAST CANCER RECURRENCE?

Maturitas ◽  
2009 ◽  
Vol 63 ◽  
pp. S94
Author(s):  
A. Sassi ◽  
F. Liebens ◽  
B. Carly ◽  
M. Tondeur ◽  
S. Rozenberg
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Risk Factor ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Mineral Density

scholarly journals IL-8 correlates with reduced baseline femoral neck bone mineral density in adults with cystic fibrosis: a single center retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Grace Y. Lam ◽  
Sameer Desai ◽  
Joey Fu ◽  
Xun Yang Hu ◽  
Jiah Jang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cystic Fibrosis ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Forced Expiratory Volume ◽  
Inflammatory Biomarkers ◽  
Mineral Density ◽  
Baseline Serum ◽  
Average Percentage ◽  
System Disease

AbstractCystic fibrosis (CF) is a multi-system disease that is characterized by lung disease due to recurrent airway infection and inflammation. Endocrine complications, such as CF bone disease (CFBD), are increasingly identified as patients are living longer. The cause of CFBD is multifactorial with chronic systemic inflammation theorized to be a contributing factor. Thus, we attempted to identify inflammatory biomarkers that are associated with CFBD. We conducted a retrospective observational study of 56 adult patients with CF with an average percentage predictive forced expiratory volume in one second (ppFEV1) of 73.7% (standard deviation: 30.0) who underwent baseline serum analysis for osteoprotegerin (OPG) and pro-inflammatory biomarkers (IL-1β, IL-6, IL-8 and TNF-α), and had repeated dual-energy x-ray absorptiometry (DXA) scans separated by at least 2 years to examine correlations between serum biomarkers and bone mineral density (BMD) measurements. Univariate linear regression model analysis demonstrated that serum IL-1β and IL-8, but not other pro-inflammatory markers, were negatively correlated with baseline BMD results. However, after accounting for confounding variables, only the relationship between IL-8 and left femoral neck BMD remained statistically significant. Additionally, IL-8 level was associated with BMD decline over time. These results suggest that IL-8 might play a unique role in the pathophysiology of CFBD relative to other pro-inflammatory cytokines but further study is warranted before firm conclusions can be made.

scholarly journals Evaluation of association of fragility fracture and bone mineral density in Nepalese population

2013 ◽  
Vol 2 (2) ◽  
pp. 130-134
Author(s):  
Md. Farid Amanullah ◽  
BP Shrestha ◽  
GP Khanal ◽  
NK Karna ◽  
S Ansari ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Bone Mineral ◽  
Fragility Fracture ◽  
High Energy ◽  
Medical Illness ◽  
Mineral Density ◽  
T Score ◽  
Study Results

Background: Fragility fractures are one of the major health problems. Many factors are associated with it some of which are modifiable and some are not. If we know the value of T-score at which fragility fracture occurs and associated factors responsible for fragility fracture than we will be able to control this burden to the society. The objective of this study is to determine association between fragility fracture and bone mineral density (BMD) using bone densitometry and to know the value of T-score at which fragility fracture occurs. Methods: Patients presenting to B.P. Koirala Institute of Health Sciences with fragility fracture of distal end of radius, fracture around hip and vertebral fractures were included in the study to know the value of T-score at which fragility fracture occurs and their associated risk factor. Patients less than 50 years of age, high energy trauma fracture and pathological fractures were excluded from the study. Results: We found that being multipara, smoking, alcohol consumption, post-hysterectomized patients and steroid intake had significant association with fragility fracture. There was no association with religion, geographic location, associated medical illness, age, sex, associated injury and site of injury. Conclusion: The patients with risk factor for fragility fracture like smoking, alcohol consumption, multipara women, post-hysterectomized women and those who are on long term steroid therapy should undergo BMD test and the value at -3.254 are prone to fragility fracture and should be treated accordingly. Nepal Journal of Medical Sciences | Volume 02 | Number 02 | July-December 2013 | Page 130-134 DOI: http://dx.doi.org/10.3126/njms.v2i2.8956

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