Orbital inflammatory disease and bone destruction

Periodontitis, an inflammatory disease of oxidative stress, occurs due to the excess reactive oxygen species (ROS) contributing to cell and tissue damage that in turn leads to alveolar bone resorption...

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TLRs Play Crucial Roles in Regulating RA Synoviocyte

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200427115225 ◽

2020 ◽

Vol 20 (8) ◽

pp. 1156-1165 ◽

Cited By ~ 2

Author(s):

Xuling Luo ◽

Juncheng Cui ◽

Xin Long ◽

Zhiwei Chen

Keyword(s):

Rheumatoid Arthritis ◽

T Cell ◽

Inflammatory Disease ◽

Chinese Herb ◽

Bone Destruction ◽

Inflammatory Factors ◽

Exact Role ◽

Autoimmune Inflammatory Disease ◽

Fibroblast Like Synoviocytes

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease comparing the inflammation of synovium. Macrophage-like synoviocytes and fibroblast-like synoviocytes (synoviocytes) are crucial ingredients of synovium. Therein, a lot of research has focused on synoviocytes. Researches demonstrated that TLR1, TLR2, TLR3, TLR4, TLR5, TLR6 TLR7 and TLR9 are expressed in synoviocyte. Additionally, the expression of TLR2, TLR3, TLR4 and TLR5 is increased in RA synoviocyte. In this paper, we review the exact role of TLR2, TLR3, TLR4 and TLR5 participate in regulating the production of inflammatory factors in RA synoviocyte. Furthermore, we discuss the role of vasoactive intestinal peptide (VIP), MicroRNA, Monome of Chinese herb and other cells (Monocyte and T cell) influence the function of synoviocyte by regulating TLRs. The activation of toll-like receptors (TLRs) in synoviocyte leads to the aggravation of arthritis, comparing with angiogenesis and bone destruction. Above all, TLRs are promising targets for managing RA.

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The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation

International Journal of Molecular Sciences ◽

10.3390/ijms221910349 ◽

2021 ◽

Vol 22 (19) ◽

pp. 10349

Author(s):

Xingzhi Wang ◽

Fuyuki Sato ◽

Keiji Tanimoto ◽

Niveda Rajeshwaran ◽

Lakshmi Thangavelu ◽

...

Keyword(s):

Chronic Inflammation ◽

Inflammatory Disease ◽

Clock Genes ◽

Bone Destruction ◽

Attachment Loss ◽

Periodontal Inflammation

Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in inflammation. In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important functions in autophagy and in pyroptosis, which contribute to the onset of periodontal inflammation. In this review, we summarize recent studies on the roles of clock genes, including Dec1 and Dec2, that are related to periodontal inflammation and other diseases.

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Nanomedicine: an emerging era of theranostics and therapeutics for rheumatoid arthritis

Rheumatology ◽

10.1093/rheumatology/kez286 ◽

2019 ◽

Vol 58 (10) ◽

pp. 1715-1721 ◽

Cited By ~ 3

Author(s):

Naila Qamar ◽

Ammara Arif ◽

Attya Bhatti ◽

Peter John

Keyword(s):

Rheumatoid Arthritis ◽

Targeted Therapy ◽

Side Effects ◽

Inflammatory Disease ◽

Therapeutic Strategy ◽

Bone Destruction ◽

Mortality Rates ◽

Autoimmune Inflammatory Disease ◽

Target Side ◽

Novel Therapeutic

Abstract RA is a multifactorial autoimmune inflammatory disease characterized by synovitis, bone destruction and joint dysfunction that leads to shortening of lifespan and increased mortality rates. Currently available treatments of RA, by controlling various symptoms, only delay disease progression and have their own side effects. Consequently, there is the need for a novel therapeutic strategy that offers a more sustainable and biocompatible solution. Nanomedicine is a modern branch of nanobiotechnology that provides targeted therapy to inflamed rheumatic joints and thus prevents unwanted off-target side effects. This review highlights various nanotheranostic and nanotherapeutic strategies that are currently being used for the treatment of RA.

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Antiangiogenesis Offers New Tactic for Inflammatory Disease

Skin & Allergy News ◽

10.1016/s0037-6337(09)70529-7 ◽

2009 ◽

Vol 40 (11) ◽

pp. 13

Author(s):

BRUCE JANCIN

Keyword(s):

Inflammatory Disease

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Diagnostik und Therapie der Adnexitis (Pelvic Inflammatory Disease)

Therapeutische Umschau ◽

10.1024/0040-5930/a001171 ◽

2020 ◽

Vol 77 (4) ◽

pp. 164-170

Author(s):

Franziska Siegenthaler ◽

Elke Krause ◽

Michael D. Mueller

Keyword(s):

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

Diagnostik Und Therapie ◽

Operative Exploration

Zusammenfassung. Die Adnexitis, im anglo-amerikanischen Sprachgebrauch hat sich der Sammelbegriff Pelvic Inflammatory Disease (PID) durchgesetzt, stellt ein häufiges medizinisches Problem dar. Die Diagnose einer PID kann schwierig sein, da die klinischen Manifestationen unspezifisch sind und sie andere Becken- und Bauchprozesse imitieren können. Infektionen im Bereich der Adnexen können schwerwiegend sein und Langzeitkomplikationen (chronische Unterbauchschmerzen, Infertilität) verursachen, weshalb eine rasche Diagnosestellung und der frühzeitige Beginn einer adäquaten Antibiotika Therapie von grosser Wichtigkeit sind. Unkomplizierte PID haben meistens einen günstigen Verlauf, bei komplizierten Formen mit Tuboovarialabzess ist meist eine operative Exploration notwendig.

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