scholarly journals The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation

2021 ◽  
Vol 22 (19) ◽  
pp. 10349
Author(s):  
Xingzhi Wang ◽  
Fuyuki Sato ◽  
Keiji Tanimoto ◽  
Niveda Rajeshwaran ◽  
Lakshmi Thangavelu ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Inflammatory Disease ◽  
Clock Genes ◽  
Bone Destruction ◽  
Attachment Loss ◽  
Periodontal Inflammation

Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in inflammation. In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important functions in autophagy and in pyroptosis, which contribute to the onset of periodontal inflammation. In this review, we summarize recent studies on the roles of clock genes, including Dec1 and Dec2, that are related to periodontal inflammation and other diseases.

Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting ROS-NFκB pathway

Nanoscale ◽  
2022 ◽  
Author(s):  
Yijun Yu ◽  
Sheng Zhao ◽  
Deao Gu ◽  
Bijun Zhu ◽  
Hanxiao Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Bone Resorption ◽  
Inflammatory Disease ◽  
Tissue Damage ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Oxygen Species ◽  
Nfκb Pathway ◽  
Excess Reactive Oxygen Species

Periodontitis, an inflammatory disease of oxidative stress, occurs due to the excess reactive oxygen species (ROS) contributing to cell and tissue damage that in turn leads to alveolar bone resorption...

scholarly journals Primary Fallopian Tube Carcinoma Arising in the Setting of Chronic Pelvic Inflammatory Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ibrahim M. Zardawi
Keyword(s):  
Ovarian Cancer ◽  
Pelvic Inflammatory Disease ◽  
Chronic Inflammation ◽  
Fallopian Tube ◽  
Inflammatory Disease ◽  
Fallopian Tube Carcinoma ◽  
Fallopian Tube Cancer ◽  
Primary Fallopian Tube Carcinoma ◽  
Gynaecological Malignancy

Primary fallopian tube cancer (PFTC) is a rare gynaecological malignancy, clinically often mistaken for pelvic inflammatory disease or ovarian cancer. Three primary fallopian tube carcinomas, arising in a background of chronic pelvic inflammatory disease (PID), are presented. The possible association between chronic PID and PFTC is discussed and a hypothesies linking these cancers with chronic inflammation is proposed.

Effects of the selective EP4antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis

2008 ◽  
Vol 60 (6) ◽  
pp. 723-730 ◽  
Author(s):  
Takako Okumura ◽  
Yoko Murata ◽  
Kana Taniguchi ◽  
Akio Murase ◽  
Aisuke Nii
Keyword(s):  
Chronic Inflammation ◽  
Bone Destruction ◽  
Adjuvant Induced Arthritis

scholarly journals The Enigmatic Cytokine Oncostatin M and Roles in Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-23 ◽  
Author(s):  
Carl D. Richards
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Cell Proliferation ◽  
Chronic Inflammation ◽  
Inflammatory Disease ◽  
Oncostatin M ◽  
Therapeutic Approaches ◽  
Pleiotropic Functions

Oncostatin M is a secreted cytokine involved in homeostasis and in diseases involving chronic inflammation. It is a member of the gp130 family of cytokines that have pleiotropic functions in differentiation, cell proliferation, and hematopoetic, immunologic, and inflammatory networks. However, Oncostatin M also has activities novel to mediators of this cytokine family and others and may have fundamental roles in mechanisms of inflammation in pathology. Studies have explored Oncostatin M functions in cancer, bone metabolism, liver regeneration, and conditions with chronic inflammation including rheumatoid arthritis, lung and skin inflammatory disease, atherosclerosis, and cardiovascular disease. This paper will review Oncostatin M biology in a historical fashion and focus on its unique activities, in vitro and in vivo, that differentiate it from other cytokines and inspire further study or consideration in therapeutic approaches.

scholarly journals A Brief Overview Presented at Dry Eye University of Inflammation in Chronic Dry Eye Disease

2020 ◽  
Vol 3 ((SP1)) ◽  
pp. e17-e18
Author(s):  
Jerry Robben
Keyword(s):  
Chronic Inflammation ◽  
Dry Eye ◽  
Inflammatory Disease ◽  
Chronic Inflammatory Disease ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Common Enemy ◽  
And Control

Inflammation is a common enemy of any chronic inflammatory disease. Dry eye is no different. Once this diagnosis is made, then one of the first objectives is to address and control the chronic inflammation appropriately.

scholarly journals Prevalence and characteristics of aggressive periodontitis

2011 ◽  
Vol 23 (2) ◽  
Author(s):  
Diatri Nariratih ◽  
Janti Rusjanti ◽  
Agus Susanto
Keyword(s):  
Periodontal Disease ◽  
Diagnostic Criteria ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Aggressive Periodontitis ◽  
Attachment Loss ◽  
Localized Aggressive Periodontitis ◽  
Low Prevalence ◽  
Age Range ◽  
Bilateral Destruction

Aggressive Periodontitis is one of periodontal disease that generally affects individuals less than 30 years old, with a rapid attachment loss and alveolar bone destruction. Special features of the disease are affected incisors and first molars with symmetrical bilateral destruction. The purpose of this study was to determine the prevalence and characteristics of Aggressive Periodontitis at Student Clinics, Faculty of Dentistry Padjadjaran University on May to July 2010. Based on accidentally sampling, 415 new patients at Dental and Oral Hospital, Faculty of Dentistry Padjadjaran University and Dental and Oral Polyclinic at RSUP dr. Hasan Sadikin Bandung participated in this study. Each subject filled out the questionnaire and did a clinical examination. Patients with attachment loss ≥ 4 mm were referred for radiographic and microbiologic examination to support the diagnosis. The results showed that there were 13 patients who have the diagnostic criteria of Aggressive Periodontitis. Nine patients were diagnosed as Localized Aggressive Periodontitis, and 4 patients as Generalized Aggressive Periodontitis. It is concluded that the prevalence of Aggressive Periodontitis was 3.13%, and indicated low prevalence. Characteristics of Localized Aggressive Periodontitis patients were female in 20-29 age range, whereas characteristics of Generalized Aggressive Periodontitis patients were male in 30-39 age range.

scholarly journals Xanthogranulomatous salpingitis - pathological aspect of chronic pelvic inflammatory disease in a patient with sigmoid diverticulitis

2018 ◽  
Vol 7 (9) ◽  
pp. 3893
Author(s):  
Sunil Kumar Juneja ◽  
Satpal Singh Virk ◽  
Anjali Sharma ◽  
Neena Sood ◽  
Ajit Sood
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Chronic Inflammation ◽  
Inflammatory Disease ◽  
Inflammatory Process ◽  
Plasma Cells ◽  
Sigmoid Diverticulitis ◽  
Polymorphonuclear Leucocytes ◽  
Xanthogranulomatous Inflammation

A case of Xanthogranulomatous salpingitis in 55yrs old women with sigmoid diverticulitis is presented. Xanthogranulomatous inflammation is an uncommon form of chronic inflammation which affects various organs and is destructive in nature. This inflammatory process is characterized by massive infiltration of the tissues by lipid laden histiocytes admixed with lymphocytes, plasma cells and polymorphonuclear leucocytes. Pelvic inflammatory disease is the main etiology. This could have possibly resulted in xanthomatous process in our case leading to xanthogranulomatous salpingitis.

scholarly journals IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors

2020 ◽  
Vol 217 (9) ◽  
Author(s):  
James W. Swann ◽  
Lada A. Koneva ◽  
Daniel Regan-Komito ◽  
Stephen N. Sansom ◽  
Fiona Powrie ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Chronic Inflammation ◽  
Inflammatory Disease ◽  
Erythropoietin Receptor ◽  
Erythroid Progenitors ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells

An important comorbidity of chronic inflammation is anemia, which may be related to dysregulated activity of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow (BM). Among HSPCs, we found that the receptor for IL-33, ST2, is expressed preferentially and highly on erythroid progenitors. Induction of inflammatory spondyloarthritis in mice increased IL-33 in BM plasma, and IL-33 was required for inflammation-dependent suppression of erythropoiesis in BM. Conversely, administration of IL-33 in healthy mice suppressed erythropoiesis, decreased hemoglobin expression, and caused anemia. Using purified erythroid progenitors in vitro, we show that IL-33 directly inhibited terminal maturation. This effect was dependent on NF-κB activation and associated with altered signaling events downstream of the erythropoietin receptor. Accordingly, IL-33 also suppressed erythropoietin-accelerated erythropoiesis in vivo. These results reveal a role for IL-33 in pathogenesis of anemia during inflammatory disease and define a new target for its treatment.

scholarly journals Orbital inflammatory disease and bone destruction

Eye ◽  
1992 ◽  
Vol 6 (6) ◽  
pp. 662-664 ◽  
Author(s):  
I F Whyte ◽  
J D H Young ◽  
W Guthrie ◽  
E G Kemp
Keyword(s):  
Inflammatory Disease ◽  
Bone Destruction
Sign in / Sign up

Export Citation Format

Share Document