Genetic causal attributions for weight status and weight loss during a behavioral weight gain prevention intervention

e11090 Background: Weight gain is a common problem after breast cancer diagnosis and treatment, particularly for women who receive chemotherapy. The weight gain has negative effects on quality of life, increases risk for chronic disease, and may increase risk of breast cancer recurrence. This pilot study tested a behavioral weight gain prevention intervention on weight, IGF-I, and IGFBP-3. Methods: Thirty-nine breast cancer patients receiving neoadjuvant chemotherapy were randomized to the weight gain prevention intervention or usual care. The intervention focused on exercise (resistance training, aerobic) and eating a low energy dense diet. Participants received 20 sessions during chemotherapy (14 in person and 6 by telephone) and 9 sessions after surgery (3 in person, 6 by telephone). They completed weight and other assessments at baseline (t0), mid-chemotherapy (T1), post-chemotherapy (t2), post surgical recovery (T3), after the post-surgical intervention (T4) and long term follow-up 6-9 months post surgery (T5). Serum was collected at T0, T2, T3, and T5 and analyzed for IGF-I and IGFBP-3. Results: Controlling for baseline weight, the intervention group weighed less than the control group at T1-T4, a result which approached significance (p=.08) in the intent to treat analysis. There was also a significant obesity x treatment group interaction, indicating that the intervention was most effective for patients who were obese at baseline (p=0.03). The groups did not differ in weight at the post-intervention follow-up (p=0.839). There was no significant difference between the groups in IGF-I or IGFBP-3. Conclusions: A diet and exercise intervention delivered during and after chemotherapy can promote weight loss in breast cancer patients, but the results may not be sustained after the intervention ends. [caption]Participants’ weights in kilograms, adjusted for baseline weight (least squares means).[caption] [Table: see text]

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Interventions for Weight Loss and Weight Gain Prevention Among Youth

Sports Medicine ◽

10.2165/00007256-200131030-00002 ◽

2001 ◽

Vol 31 (3) ◽

pp. 153-165 ◽

Cited By ~ 42

Author(s):

Janet E. Fulton ◽

Maureen T. McGuire ◽

Carl J. Caspersen ◽

William H. Dietz

Keyword(s):

Weight Loss ◽

Weight Gain ◽

Weight Gain Prevention

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4098 Health and HIV: Weight status associations with multiple co-morbidities

Journal of Clinical and Translational Science ◽

10.1017/cts.2020.395 ◽

2020 ◽

Vol 4 (s1) ◽

pp. 133-133

Author(s):

Kierra Renee Butler ◽

Faye R. Harrell ◽

Jeffrey Robinson ◽

Bridgett Rahim-Williams ◽

Wendy A. Henderson

Keyword(s):

Weight Loss ◽

Weight Gain ◽

Highly Active Antiretroviral Therapy ◽

Weight Status ◽

Latent Class ◽

Healthy Weight ◽

Shortness Of Breath ◽

Personalized Care ◽

Co Morbidity ◽

Gi Symptoms

OBJECTIVES/GOALS: Highly Active Antiretroviral Therapy (HAART) is beneficial for managing HIV infection, however the long-term use of HAART may be problematic for healthy weight maintenance. The aim of the study was to investigate the association of race, weight status, and co-morbidities among individuals with HIV. METHODS/STUDY POPULATION: Self-reported data from 283 participants who completed the Symptom Checklist, the Co-Morbidity Questionnaire, and the Sociodemographic Questionnaire were included in the data analyses. Data were analyzed using Latent Class Analysis on JMP 13. Approximately 50% of participants self-identified as Black, 69% as male, and 35% as having AIDS. Participants’ age ranged from 25 to 66 years (mean age = 43.70 years, SD = 8.14). Participants were grouped by race (self- reported Black or non-Black), and then each group was clustered based on the top three most prevalent symptoms. The clusters identified were least symptomatic, weight gain, and weight loss. RESULTS/ANTICIPATED RESULTS: The non-Black weight gain cluster reported a higher incidence of AIDS (70.6% vs 38.2%), nausea (70.6% vs 17.6%), diarrhea (70.6% vs 26.5%), and shortness of breath (58.8% vs 20.6%) compared to the Black weight gain cluster. The Black weight loss cluster reported a higher incidence of cardiovascular symptoms including chest palpitations (42.2% vs 2.7%), chest pain (44.4% vs 8.1%), and shortness of breath (73.3% vs 35.1%) and a higher incidence of all GI symptoms with the most prominent being diarrhea (71.1% vs 48.6%) compared to the non-Black weight loss cluster. DISCUSSION/SIGNIFICANCE OF IMPACT: Future studies supporting these results will assist practitioners to target treatments that may prevent adverse health outcomes for individuals with HIV on HAART. Further studies will also assist with setting standards that allow practitioners to provide personalized care for individuals with HIV on HAART.

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Maintaining the Outcomes of a Successful Weight Gain Prevention Intervention in Mid-Age Women: Two Year Results from the 40-Something Randomized Control Trial

Nutrients ◽

10.3390/nu11051100 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1100

Author(s):

Lauren T. Williams ◽

Clare E. Collins ◽

Philip J. Morgan ◽

Jenna L. Hollis

Keyword(s):

Weight Loss ◽

Weight Gain ◽

Health Professional ◽

Obesity Prevention ◽

Controlled Trial ◽

Life Stage ◽

Premenopausal Women ◽

Intervention Effects ◽

Prevention Intervention ◽

Percentage Body Fat

Despite the life stage of menopause being identified as a high risk for weight gain, there are few obesity prevention interventions for this target group, and no evidence on maintenance of intervention effects after intervention support is withdrawn. In the 40-Something Randomized Controlled Trial (RCT) (ACTRN12611000064909), a five-consultation health professional (dietitian and exercise physiologist) obesity prevention intervention, using motivational interviewing principles (MI) over 12 months, achieved significantly greater weight loss than a self-directed intervention (SDI) (tailored written material) in 54 non-obese (body mass index (BMI): 18.5–29.9 kg/m2), premenopausal women (44–50 years). The aim of the current paper is to report on whether the intervention effects were maintained at two years. Anthropometric, biochemical and health behavior data were collected at baseline, 12 months (end of intervention) and 24 months (end of maintenance period). Forty participants (22 = MI, 18 = SDI) who completed all measures to 12 months were invited to participate in the monitoring phase and 30 (MI = 16, SDI = 14) consented. The primary outcome of weight at 24 months was assessed using intention to treat principles (n = 54), adjusting for baseline weight. The MI group had a significantly lower weight at 24 months (64.6 kg, 95% CI: 63.2, 66.6, p = 0.015) compared with the SDI group (67.3 kg, 95% CI: 65.7, 68.8), and the secondary outcomes of percentage body fat and waist circumference were also significantly lower in the MI group. The low-intensity, health professional weight control intervention utilizing MI principles was more efficacious in maintaining a significant weight loss compared to a self-directed intervention, and both were successful in preventing obesity.

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Test of a Weight Gain Prevention Intervention in Stage II and III Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-19-3-aspo12 ◽

2010 ◽

Vol 19 (3) ◽

pp. 895.2-896 ◽

Cited By ~ 1

Author(s):

K Basen-Engquist ◽

H Perkins ◽

C Carmack ◽

D Hughes ◽

J Jovanovic ◽

...

Keyword(s):

Breast Cancer ◽

Weight Gain ◽

Neoadjuvant Chemotherapy ◽

Cancer Patients ◽

Stage Ii ◽

Weight Gain Prevention ◽

Breast Cancer Patients ◽

Prevention Intervention

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The impact of a national mass media campaign in The Netherlands on the prevention of weight gain

Public Health Nutrition ◽

10.1079/phn2005753 ◽

2005 ◽

Vol 8 (8) ◽

pp. 1250-1257 ◽

Cited By ~ 28

Author(s):

Birgitte Wammes ◽

Boudewijn Breedveld ◽

Caspar Looman ◽

Johannes Brug

Keyword(s):

Weight Gain ◽

Mass Media ◽

Risk Perceptions ◽

Weight Status ◽

Weight Gain Prevention ◽

Mass Media Campaign ◽

Media Campaign ◽

Post Intervention ◽

Cross Sectional ◽

The Impact

AbstractObjectiveA 5-year nationwide mass media campaign aimed at prevention of overweight was organised from 2002 onwards. The present study evaluates the first campaign, which was aimed primarily at increasing awareness of weight gain.Design and subjectsData were collected by telephone interview in four independent cross-sectional surveys among non-obese Dutch adults aged 25–35 years (total n = 1949) for statistical analyses. Awareness of personal body-weight status, overweight-related risk perceptions, attitudes towards weight-gain prevention, motivation to prevent weight gain and self-reported body mass index (BMI) were measured in each survey. Campaign exposure was assessed in the post-intervention surveys. To identify intervention effects over time multiple linear and logistic regression analyses were used, adjusted for secular time effects and age.ResultsAfter the campaign about 65% of the respondents knew about the campaign. The campaign was associated with more positive attitudes towards the prevention of weight gain (β = 0.16; P ≤ 0.01) and higher self-reported BMI (β = 0.14; P ≤ 0.01).ConclusionsThe results suggest that the first campaign reached a large proportion of the population and initiated some positive change in attitudes, but did not achieve significant improvements in other determinants of weight-gain prevention among non-obese young adults.

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Weight management barriers and facilitators after breast cancer in Australian women: a national survey

10.21203/rs.2.21331/v2 ◽

2020 ◽

Author(s):

Carolyn Ee ◽

Adele Elizabeth Cave ◽

Dhevaksha Naidoo ◽

Kellie Bilinski ◽

John Boyages

Keyword(s):

Breast Cancer ◽

Weight Loss ◽

Weight Gain ◽

Weight Management ◽

Breast Cancer Survivors ◽

Behavioural Change ◽

Weight Gain Prevention ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Exercise Interventions

Abstract Background: Breast cancer is the most common cancer in women worldwide. Weight gain after breast cancer is associated with poorer health outcomes. The aim of this study was to describe how Australian breast cancer survivors are currently managing their weight. Methods: Online cross-sectional survey open to any woman living in Australia who self-identified as having breast cancer, between November 2017 and January 2018. Results: We received 309 responses. Most respondents described their diet as good/excellent and reported moderate-high levels of weight self-efficacy. Despite this, the proportion of overweight/obesity increased from 47% at time of diagnosis to 67% at time of survey. More than three quarters of respondents did not receive any advice on weight gain prevention at the time of diagnosis. 39% of women reported being less active after cancer diagnosis, and and few weight loss interventions were perceived to be effective. Facilitators were structured exercise programs, prescribed diets, and accountability to someone else, while commonly cited barriers were lack of motivation/willpower, fatigue, and difficulty maintaining weight. Women who cited fatigue as a barrier were almost twice as likely to be doing low levels of physical activity (PA) or no PA than women who did not cite fatigue as a barrier. Conclusions: We report high levels of concern about weight gain after BC and significant gaps in service provision around weight gain prevention and weight management. Women with BC should be provided with support for weight gain prevention in the early survivorship phase, which should include structured PA and dietary changes in combination with behavioural change and social support. Weight gain prevention or weight loss programs should address barriers such as fatigue. More research is required on the effectiveness of diet and exercise interventions in BC survivors, particularly with regard to weight gain prevention.

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