Association between the p22phox −930A/G polymorphism and blood pressure in normotensive subjects

1. As experimental models of reduced nephron population in man, (a) twelve men aged 15–32 years who had one kidney removed 1–13 years previously and (b) fourteen normotensive men aged 70–90 years were studied. Results were compared with those in eighteen normotensive men aged 18–28 years and eleven men aged 19–33 years with essential hypertension. 2. While the subjects followed a routine of normal diet and daily activity, measurements were made, after overnight recumbency and in the fasting state, of plasma volume and renin activity on one occasion in hospital and of blood pressure on five to fourteen occasions in the home. Blood pressure was also measured after standing for 2 min and plasma renin activity after 1 h standing, sitting or walking. Twenty-four hour urinary aldosterone excretion was also measured. 3. The measurements were repeated in the normotensive subjects and subjects in (a) and (b) above after 10 days of sodium-restricted diet (40 mmol of sodium/day). 4. The mean plasma renin activity (recumbent) in essential hypertensive subjects was higher than in normotensive subjects. In subjects of (a) and (b) above, it was lower than normotensive subjects, and was not increased by dietary sodium restriction in subjects of (a). 5. The mean aldosterone excretion level was lower in old normotensive subjects than in the other groups, and increased in each group after dietary sodium restriction. 6. Mean plasma volume/surface area was not different between the four groups and in normotensive, essential hypertensive and nephrectomized subjects but not subjects aged 70–90 years was negatively correlated with standing diastolic blood pressure.

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Altered blood pressure during sleep in normotensive subjects with type I diabetes.

Hypertension ◽

10.1161/01.hyp.21.2.227 ◽

1993 ◽

Vol 21 (2) ◽

pp. 227-235 ◽

Cited By ~ 102

Author(s):

A Lurbe ◽

J Redón ◽

J M Pascual ◽

J Tacons ◽

V Alvarez ◽

...

Keyword(s):

Blood Pressure ◽

Type I Diabetes ◽

Type I ◽

Normotensive Subjects ◽

Altered Blood

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Classification of Hypertensive and Normotensive Subjects Using Bilateral Differential Biopotential Signals

10.21203/rs.3.rs-813015/v1 ◽

2021 ◽

Author(s):

Arindam Sarkar ◽

Bhaswati Goswami ◽

Ratna Ghosh

Keyword(s):

Blood Pressure ◽

Random Forest ◽

High Blood Pressure ◽

Pivotal Role ◽

Modern World ◽

Hypertensive Subject ◽

Normotensive Subjects ◽

Electrocardiogram Ecg ◽

Day By Day

Abstract Hypertension or high blood pressure is a severe health issue in the modern world, especially in this pandemic scenario, that can cause many heart related diseases or even death, and it is increasing day by day. For this reason, a reliable, automatic and easy to use system for hypertensive subject detection is an important focus for the researchers. Biopotential signals can play a pivotal role in this regard. Though, few strategies were proposed based on electrocardiogram (ECG) or electrodermal (EDA) signals, but those require special circuitry, as well as trained persons. In this article, a method is proposed to classify hypertensive and normotensive subjects using differential biopotential signals. Neither special circuitry, nor much expertise is required for handling this system. It was assumed that progression of rest is dependent upon blood pressure. To serve the purpose, signals were acquired from both hypertensive and normotensive subjects bilaterally for 10 continuous minutes. Result of the random forest (RF) classification establishes that from the analysis of the progression of the bilaterally acquired differential biopotential signals, hypertensive subjects can be distinguished from normotensive subjects.

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Blood pressure responses to hypnotic and nonhypnotic suggestions in normotensive subjects

Pavlovian Journal of Biological Science ◽

10.1007/bf02995041 ◽

1986 ◽

Vol 21 (1) ◽

pp. 32-35 ◽

Cited By ~ 1

Author(s):

Helge Sletvold ◽

Geirr Molde Jensen ◽

K. Gunnar Götestam

Keyword(s):

Blood Pressure ◽

Normotensive Subjects ◽

Blood Pressure Responses

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Abstract 531: Regulation of Plasma 20-HETE and Soluble Epoxide Hydrolase by Salt Balance in Normotensive Subjects

Hypertension ◽

10.1161/hyp.64.suppl_1.531 ◽

2014 ◽

Vol 64 (suppl_1) ◽

Author(s):

Fernando Elijovich ◽

Nancy J Brown ◽

Ginger L Milne ◽

Cheryl L Laffer

Keyword(s):

Blood Pressure ◽

Epoxide Hydrolase ◽

Direct Relationship ◽

Soluble Epoxide Hydrolase ◽

Salt Balance ◽

Sodium Depletion ◽

Salt Loading ◽

Normotensive Subjects ◽

Stimulation Of

The tissue sources of circulating and urinary 20-HETE and EETs are not well known. We have previously shown urine 20-HETE abnormalities in salt-sensitive (SS) hypertension. We studied plasma 20-HETE and EETs in normotensive volunteers classified as SS or salt resistant (SR) with an acute protocol of salt loading (HS, 460 mmol diet and iv) and depletion (LS, 10 mmol and furosemide). Plasma 20-HETE and total (EET+DHET) or active EET did not differ between SR and SS during baseline (B, UNaV 146±17 mmol/24hr), HS (422±20) or LS (24±6). In normal SR subjects, HS did not affect the levels of either eicosanoid but reduced degradation of EETs into DHETs by decreasing the activity of soluble epoxide hydrolase (sEH or DHET/[EET+DHET]). No major clinical or biochemical correlates for plasma 20-HETE were identified in B, HS or LS. In SR but not SS, EET+DHET (r=0.57, p<0.003) and DHET (r=0.45, p<0.03) correlated with aldosterone during B and HS. LS stimulated 20-HETE in both SS and SR and also unexpectedly increased EET+DHET in SR subjects. This did not lead to increased EETs because of concomitant stimulation of sEH with increased degradation into DHETs. In SR, stimulation of 20-HETE by LS correlated with greater natriuresis (r=0.71, p<0.02), greater reduction of MAP (r=0.66, p<0.03) and lesser stimulation of aldosterone (r=0.64, p<0.04), relationships not observed in SS. Finally, in SR subjects only, during B and HS, plasma 20-HETE correlated with the activity of sEH (r=0.56, p<0.005) and levels of DHET (r=0.63, p<0.001), but not with total or active EETs. Our data on stimulation of plasma 20-HETE by LS and its correlates (markers of severity of sodium depletion) suggest recruitment of systemic vasoconstrictor 20-HETE for maintenance of BP. Plasma EET responses to HS and LS are not consistent with its renal natriuretic role but correlate with aldosterone responses to salt balance, perhaps reflecting modulation of aldosterone actions on extrarenal ENaC. Although no significant correlations were detected between blood pressure and EETs, there was a direct relationship between plasma 20-HETE, sEH activity and degradation of EETs into DHETs. This suggests coordinated vasoconstriction and vasodilation by these eicosanoids in normal SR humans, which is disrupted in normotensive SS.

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Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients

The Scientific World JOURNAL ◽

10.1100/2012/348246 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Carlos Ricardo Maneck Malfatti ◽

Leandro Tibiriçá Burgos ◽

Alexandre Rieger ◽

Cássio Luiz Rüdger ◽

Janaína Angela Túrmina ◽

...

Keyword(s):

Blood Pressure ◽

Atpase Activity ◽

Cell Damage ◽

Venous Blood ◽

Thiobarbituric Acid ◽

Normal Blood Pressure ◽

Thiobarbituric Acid Reactive Substances ◽

Normotensive Subjects ◽

The Relationship ◽

Membrane Cell

The essential hypertension has been associated with membrane cell damage. The aim of the present study is investigate the relationship between erythrocyte Na+,K+-ATPase and lipoperoxidation in prehypertensive patients compared to normotensive status. The present study involved the prehypertensive patients (systolic:136±7 mmHg; diastolic:86.8±6.3 mmHg;n=8) and healthy men with normal blood pressure (systolic:110±6.4 mmHg; diastolic:76.1±4.2 mmHg;n=8) who were matched for age (35±4years old). The venous blood samples of antecubital vein (5 mL) were collected into a tube containing sodium heparin as anticoagulant (1000 UI), and erythrocyte ghosts were prepared for quantifying Na+,K+-ATPase activity. The extent of the thiobarbituric acid reactive substances (TBARS) was determined in plasma. The statistical analysis was carried out by Student’st-test and Pearson’s correlation coefficient. AP<0.05was considered significant. The Na+,K+-ATPase activity was lower in prehypertensive patients compared with normotensive subjects (4.9 versus 8.0 nmol Pi/mg protein/min;P<0.05). The Na+,K+-ATPase activity correlated negatively with TBARS content (r=-0.6;P<0.05) and diastolic blood pressure (r=-0.84;P<0.05). The present study suggests that Na+,K+-ATPase activity reduction and elevation of the TBARS content may underlie the pathophysiological aspects linked to the prehypertensive status.

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Daily Life Blood Pressure Changes Are Steeper in Hypertensive Than in Normotensive Subjects

Hypertension ◽

10.1161/01.hyp.0000084632.33942.5f ◽

2003 ◽

Vol 42 (3) ◽

pp. 277-282 ◽

Cited By ~ 52

Author(s):

Giuseppe Mancia ◽

Gianfranco Parati ◽

Paolo Castiglioni ◽

Roberto Tordi ◽

Elena Tortorici ◽

...

Keyword(s):

Blood Pressure ◽

Daily Life ◽

Normotensive Subjects ◽

Pressure Changes

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Blood Pressure and Immunoglobulins

Clinical Science ◽

10.1042/cs0650665 ◽

1983 ◽

Vol 65 (6) ◽

pp. 665-667 ◽

Cited By ~ 2

Author(s):

A. M. De Bruijn ◽

F. C. A. Geers ◽

R. S. A. J. Hylkema ◽

R. Vermeeren ◽

A. Hofman

Keyword(s):

Blood Pressure ◽

General Population ◽

Serum Concentrations ◽

Age And Gender ◽

Normotensive Subjects ◽

And Gender

1. Serum concentrations of IgG and IgM were measured in 87 hypertensive and 87 normotensive subjects, matched for age and gender, and selected from the same general population. 2. No significant differences between these two groups were found, in contrast to some previous reports. 3. The reasons for this discrepancy are discussed.

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