Effects on uric acid, body mass index and blood pressure in adolescents of consuming beverages sweetened with high-fructose corn syrup

Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

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Relationship Between High-Fructose Corn Syrup, Uric Acid, and Metabolic Syndrome

Journal of Pediatric Surgical Nursing ◽

10.1097/jps.0000000000000115 ◽

2016 ◽

Vol 5 (4) ◽

pp. 88

Author(s):

Monica J. McChesney

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

High Fructose Corn Syrup ◽

Corn Syrup ◽

High Fructose

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Body mass index, fat free mass, uric acid, and renal function as blood pressure levels determinants in young adults

Nephrology ◽

10.1111/nep.12763 ◽

2017 ◽

Vol 22 (4) ◽

pp. 279-285 ◽

Cited By ~ 4

Author(s):

Antonino Sidoti ◽

Santi Nigrelli ◽

Alberto Rosati ◽

Roberto Bigazzi ◽

Raffaele Caprioli ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Young Adults ◽

Renal Function ◽

Uric Acid ◽

Body Mass ◽

Fat Free Mass

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Relation Between Circadian Rhythm of Blood Pressure and Serum Uric Acid and Body Mass Index

Turkish Nephrology Dialysis Transplantation ◽

10.5262/tndt.2011.2001.06 ◽

2011 ◽

Vol 20 (01) ◽

pp. 32-37

Author(s):

Mehmet Kanbay ◽

Faruk Turgut ◽

Ayse Isik ◽

Mustafa Koroglu ◽

Ali Akcay

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Circadian Rhythm ◽

Serum Uric Acid ◽

Body Mass

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Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

Medical Journal of Indonesia ◽

10.13181/mji.v24i2.1068 ◽

2015 ◽

Vol 24 (2) ◽

pp. 103-8

Author(s):

Ikhlas A. Bramono ◽

Nur Rasyid ◽

Ponco Birowo

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Urinary Tract ◽

Serum Uric Acid ◽

Body Mass ◽

Glucose Level ◽

Serum Glucose ◽

Serum Glucose Level ◽

Urinary Tract Stone

Background: Urolithiasis refers to formation of stone in the kidney, ureter, or bladder. Several studies showed metabolic abnormalities were common in urolithiasis patients. The aim of this study was to describe the association between body-mass-index (BMI), serum uric acid, serum glucose, and blood pressure toward stone opacity in urinary tract stone patients.Methods: This study was done retrospectively by reviewing registry data of urinary tract stone patients that had undergone ESWL on January 2008 – December 2013 in Department of Urology Cipto Mangunkusumo Hospital. Data concerning body mass index, serum uric acid, serum glucose, blood pressure, and urinary tract stone opacity were recorded. Associations between body mass index, serum uric acid, serum glucose and blood pressure with urinary tract stone opacity were analyzed using chi-square test.Results: There were 2,889 patients who underwent ESWL on January 2008 – December 2013. We analyzed 242 subjects with complete data. Mean age was ± 12.78 (48.02 years). Male-to-female ratio was 2.27:1. Mean BMI was ± 3.78 (29.91 kg/m2). High risk BMIs were found in 161 patients (66.52%). The proportion of radioopaque stone was 77.69% (188 patients). Twenty two patients (9.1%) had normal blood pressure. Patients with high serum uric acid were 34.30% (83 patients). We found a significant association between random serum glucose level and stone opacity (p < 0.05).Conclusion: There is an association between random serum glucose level and stone opacity in urolithiasis patients. Hyperglycemia patients tend to have radiolucent stone, whereas normoglycemia patients tend to have radioopaque stone.

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Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study

International Journal of Obesity ◽

10.1038/s41366-021-00810-9 ◽

2021 ◽

Author(s):

Miaoying Yun ◽

Tao Zhang ◽

Shengxu Li ◽

Xuan Wang ◽

Lijun Fan ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Body Mass ◽

Temporal Relationship ◽

Mediation Effect ◽

Mediation Analyses ◽

Path Coefficients ◽

Analysis Models

Abstract Objective This study aimed to examine the temporal relationship between body mass index (BMI) and uric acid (UA), and their joint effect on blood pressure (BP) in children and adults. Methods The longitudinal cohorts for temporal relationship analyses consisted of 564 and 911 subjects examined twice 5–14 years apart from childhood to adulthood. The cross-sectional cohorts for mediation analyses consisted of 3102 children and 3402 nondiabetic adults. Cross-lagged panel analysis models were used to examine the temporal relationship between BMI and UA, and mediation analysis models the mediation effect of UA on the BMI–BP association. Results After adjusting for age, race, sex and follow-up years in children, and additionally smoking and alcohol drinking in adults, the path coefficients (standardized regression coefficients) from baseline BMI to follow-up UA (0.145 in children and 0.068 in adults) were significant, but the path coefficients from baseline UA to follow-up BMI (0.011 in children and 0.016 in adults) were not. In mediation analyses, indirect effects through UA on the BMI-systolic BP association were estimated at 0.028 (mediation effect = 8.8%) in children and 0.033 (mediation effect = 13.5%) in adults (P < 0.001 for both). Direct effects of BMI on systolic BP (0.289 in children and 0.212 in adults) were significant. The mediation effect parameters did not differ significantly between Blacks and Whites. Conclusions Changes in BMI precede alterations in UA, and the BMI–BP association is in part mediated through BMI-related increase in UA both in children and in adults. These findings have implications for addressing mechanisms of obesity hypertension beginning in early life.

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High fructose corn syrup supplementation progressively increased serum adenosine and inosine: Inosine raising blood pressure and heart rate in rats

Acta Universitaria ◽

10.15174/au.2021.2923 ◽

2021 ◽

Vol 31 ◽

pp. 1-9

Author(s):

Rafael Villalobos-Molina

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Wistar Rats ◽

Cardiovascular Function ◽

High Fructose Corn Syrup ◽

Long Term Effects ◽

Corn Syrup ◽

Arterial Blood ◽

High Fructose

High fructose corn syrup (HFCS) over-consumption underlies the obesity worldwide epidemics. Hepatic fructose metabolism includes fructolysis, lipogenesis, and purines degradation to uric acid. The aim of this study was to evaluate HFCS long-term effects on serum and hepatic adenosine (Ado) and inosine (Ino), as well as in vivo Ino effects on cardiovascular function. Fed male Wistar rats were subjected to 30% HFCS-enriched drinking water for five months (n = 15); every month, nucleosides were determined in serum and in isolated liver perfusate. Three months-old male naive Wistar rats were pithed and cannulated to record blood pressure and heart rate after Ino administration (n = 3). Rats consuming HFCS increased both Ado and Ino progressively in serum and livers’ perfusate; Ino increased cardiovascular function. The progressive Ado and Ino hepatic release by fructose-enriched diet suggests their contribution to raise glycemia through their gluconeogenic activation, and a higher serum Ino concentration might be related to increase in arterial blood pressure.

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Abstract P398: Uric Acid And Prehypertension: Salt Intake in Addition to Insulin Resistance are not Mediators.

Circulation ◽

10.1161/circ.129.suppl_1.p398 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Paulo A Lotufo ◽

Itamar S Santos ◽

Isabela M Bensenor

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Blood Glucose ◽

Serum Uric Acid ◽

Body Mass ◽

High Blood Pressure ◽

Urinary Sodium ◽

Full Model

Introduction: The association "uric acid and high blood pressure" is still matter of debate. Therefore, to distinguish serum uric acid as an independent factor for high blood pressure can start new trials to prevent hypertension. A paleoantropological rationale for this association was a knockout of uricase occurred during the Miocene among hominids that induced high levels of uric acid. As consequence, during food shortage times, high uric acid had an evolutionary benefit increasing salt-sensitivity for keep blood pressure and rising insulin resistance that maintaining high blood glucose levels provided fuel for the brain. Nowadays, the average levels of uric acid are substantially higher compared to chimpanzees, a uricase-deficient primate, and among remote populations as the yanomamo. Hypothesis: we assessed the hypothesis that the link between uric acid and blood pressure in individuals without hypertension is independent of sex, age, race, salt and alcohol intakes, glucose homeostasis, body-mass index and renal function. Methods: from the 15105 participants of the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) aged 35-74 years, we selected 7954 individuals (median age = 48 years-old; women =58.1; White = 56.6%) without hypertension, diabetes, previous cardiovascular diseases. The presence or not of prehypertension (7th JNC criteria) was the dependent variable and quartiles (Q) of serum uric acid, the independent variable. We applied an unconditional logistic regression adjusted for age and sex. After this, according to our hypothesis, we added the following variables: (1) 24-hour urinary sodium; (2) log Homeostasis Model Assessment (fasting blood glucose (mg/dL) х fasting insulin (mg/dL)/450), and (3) a full model, adding race, body-mass index, alcohol intake, and glomerular filtration rate by CKD-epi). Results: the uric acid quartiles ranges (md/dL) were Q1 ≤ 4.1; Q2:4.2-5.0; Q3:5.1-6.0; Q4: ≥ 6.1 and the number of participants were Q1= 1909; Q2=2029; Q3=2000; Q4= 2016. Considering Q1 as reference, the age-sex adjusted odds ratios (95% Confidence Interval) through the quartiles were: Q2= 1.22 (1.05-1.41); Q3= 1.40 (1.20-1.63); Q4= 2.03 (1.71-2.39) [P for trend <0.001]. Adding 24 hour urinary sodium, the ORs (95% CI) were: Q2= 1.19 (1.01-1.40); Q3= 1.37 (1.16-1.62); and 1.94 (1.61-2.33) [P for trend <0.001]. Adding HOMA-IR, the ORs (95% CI) were: Q2= 1.14 (0.97-1.34); Q3= 1.25(1.05-1.48); and Q4=1.62(1.34-1.96) [P for trend <0.001]. Finally, for the full model the ORs were Q2= 1.04 (0.88-1.23); Q3= 1.05 (0.88-1.26) and Q4= 1.32(1.08-1.62) [P for trend <0. 01]. Conclusion: Uric acid levels were correlated to prehypertension among a middle-aged urban population. It occurred independently of other variables classically associated to high blood pressure or the origin of higher uric acid in hominids.

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