scholarly journals Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

2021 ◽  
Vol 10 (10) ◽  
pp. 2138
Author(s):  
Michał Szyszka ◽  
Piotr Skrzypczyk ◽  
Anna Stelmaszczyk-Emmel ◽  
Małgorzata Pańczyk-Tomaszewska
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Body Mass ◽  
Pediatric Patients ◽  
Univariate Analysis ◽  
Primary Hypertension ◽  
Potential Biomarker ◽  
Arterial Damage ◽  
Serum Periostin

Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

The relationship of body mass index and blood pressure in primary care pediatric patients

2006 ◽  
Vol 148 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Bonita Falkner ◽  
Samuel S. Gidding ◽  
Gabriela Ramirez-Garnica ◽  
Stacey Armatti Wiltrout ◽  
David West ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Primary Care ◽  
Body Mass Index ◽  
Body Mass ◽  
Pediatric Patients ◽  
Relationship Of ◽  
The Relationship

Body mass index, fat free mass, uric acid, and renal function as blood pressure levels determinants in young adults

Nephrology ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 279-285 ◽  
Author(s):  
Antonino Sidoti ◽  
Santi Nigrelli ◽  
Alberto Rosati ◽  
Roberto Bigazzi ◽  
Raffaele Caprioli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Young Adults ◽  
Renal Function ◽  
Uric Acid ◽  
Body Mass ◽  
Fat Free Mass

Relation Between Circadian Rhythm of Blood Pressure and Serum Uric Acid and Body Mass Index

2011 ◽  
Vol 20 (01) ◽  
pp. 32-37
Author(s):  
Mehmet Kanbay ◽  
Faruk Turgut ◽  
Ayse Isik ◽  
Mustafa Koroglu ◽  
Ali Akcay
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Circadian Rhythm ◽  
Serum Uric Acid ◽  
Body Mass

scholarly journals Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

2015 ◽  
Vol 24 (2) ◽  
pp. 103-8
Author(s):  
Ikhlas A. Bramono ◽  
Nur Rasyid ◽  
Ponco Birowo
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Urinary Tract ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Urinary Tract Stone

Background: Urolithiasis refers to formation of stone in the kidney, ureter, or bladder. Several studies showed metabolic abnormalities were common in urolithiasis patients. The aim of this study was to describe the association between body-mass-index (BMI), serum uric acid, serum glucose, and blood pressure toward stone opacity in urinary tract stone patients.Methods: This study was done retrospectively by reviewing registry data of urinary tract stone patients that had undergone ESWL on January 2008 – December 2013 in Department of Urology Cipto Mangunkusumo Hospital. Data concerning body mass index, serum uric acid, serum glucose, blood pressure, and urinary tract stone opacity were recorded. Associations between body mass index, serum uric acid, serum glucose and blood pressure with urinary tract stone opacity were analyzed using chi-square test.Results: There were 2,889 patients who underwent ESWL on January 2008 – December 2013. We analyzed 242 subjects with complete data. Mean age was ± 12.78 (48.02 years). Male-to-female ratio was 2.27:1. Mean BMI was ± 3.78 (29.91 kg/m2). High risk BMIs were found in 161 patients (66.52%). The proportion of radioopaque stone was 77.69% (188 patients). Twenty two patients (9.1%) had normal blood pressure. Patients with high serum uric acid were 34.30% (83 patients). We found a significant association between random serum glucose level and stone opacity (p < 0.05).Conclusion: There is an association between random serum glucose level and stone opacity in urolithiasis patients. Hyperglycemia patients tend to have radiolucent stone, whereas normoglycemia patients tend to have radioopaque stone.

scholarly journals Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study

2021 ◽  
Author(s):  
Miaoying Yun ◽  
Tao Zhang ◽  
Shengxu Li ◽  
Xuan Wang ◽  
Lijun Fan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Body Mass ◽  
Temporal Relationship ◽  
Mediation Effect ◽  
Mediation Analyses ◽  
Path Coefficients ◽  
Analysis Models

Abstract Objective This study aimed to examine the temporal relationship between body mass index (BMI) and uric acid (UA), and their joint effect on blood pressure (BP) in children and adults. Methods The longitudinal cohorts for temporal relationship analyses consisted of 564 and 911 subjects examined twice 5–14 years apart from childhood to adulthood. The cross-sectional cohorts for mediation analyses consisted of 3102 children and 3402 nondiabetic adults. Cross-lagged panel analysis models were used to examine the temporal relationship between BMI and UA, and mediation analysis models the mediation effect of UA on the BMI–BP association. Results After adjusting for age, race, sex and follow-up years in children, and additionally smoking and alcohol drinking in adults, the path coefficients (standardized regression coefficients) from baseline BMI to follow-up UA (0.145 in children and 0.068 in adults) were significant, but the path coefficients from baseline UA to follow-up BMI (0.011 in children and 0.016 in adults) were not. In mediation analyses, indirect effects through UA on the BMI-systolic BP association were estimated at 0.028 (mediation effect = 8.8%) in children and 0.033 (mediation effect = 13.5%) in adults (P < 0.001 for both). Direct effects of BMI on systolic BP (0.289 in children and 0.212 in adults) were significant. The mediation effect parameters did not differ significantly between Blacks and Whites. Conclusions Changes in BMI precede alterations in UA, and the BMI–BP association is in part mediated through BMI-related increase in UA both in children and in adults. These findings have implications for addressing mechanisms of obesity hypertension beginning in early life.

Abstract P398: Uric Acid And Prehypertension: Salt Intake in Addition to Insulin Resistance are not Mediators.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Isabela M Bensenor
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Body Mass ◽  
High Blood Pressure ◽  
Urinary Sodium ◽  
Full Model

Introduction: The association "uric acid and high blood pressure" is still matter of debate. Therefore, to distinguish serum uric acid as an independent factor for high blood pressure can start new trials to prevent hypertension. A paleoantropological rationale for this association was a knockout of uricase occurred during the Miocene among hominids that induced high levels of uric acid. As consequence, during food shortage times, high uric acid had an evolutionary benefit increasing salt-sensitivity for keep blood pressure and rising insulin resistance that maintaining high blood glucose levels provided fuel for the brain. Nowadays, the average levels of uric acid are substantially higher compared to chimpanzees, a uricase-deficient primate, and among remote populations as the yanomamo. Hypothesis: we assessed the hypothesis that the link between uric acid and blood pressure in individuals without hypertension is independent of sex, age, race, salt and alcohol intakes, glucose homeostasis, body-mass index and renal function. Methods: from the 15105 participants of the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) aged 35-74 years, we selected 7954 individuals (median age = 48 years-old; women =58.1; White = 56.6%) without hypertension, diabetes, previous cardiovascular diseases. The presence or not of prehypertension (7th JNC criteria) was the dependent variable and quartiles (Q) of serum uric acid, the independent variable. We applied an unconditional logistic regression adjusted for age and sex. After this, according to our hypothesis, we added the following variables: (1) 24-hour urinary sodium; (2) log Homeostasis Model Assessment (fasting blood glucose (mg/dL) х fasting insulin (mg/dL)/450), and (3) a full model, adding race, body-mass index, alcohol intake, and glomerular filtration rate by CKD-epi). Results: the uric acid quartiles ranges (md/dL) were Q1 ≤ 4.1; Q2:4.2-5.0; Q3:5.1-6.0; Q4: ≥ 6.1 and the number of participants were Q1= 1909; Q2=2029; Q3=2000; Q4= 2016. Considering Q1 as reference, the age-sex adjusted odds ratios (95% Confidence Interval) through the quartiles were: Q2= 1.22 (1.05-1.41); Q3= 1.40 (1.20-1.63); Q4= 2.03 (1.71-2.39) [P for trend <0.001]. Adding 24 hour urinary sodium, the ORs (95% CI) were: Q2= 1.19 (1.01-1.40); Q3= 1.37 (1.16-1.62); and 1.94 (1.61-2.33) [P for trend <0.001]. Adding HOMA-IR, the ORs (95% CI) were: Q2= 1.14 (0.97-1.34); Q3= 1.25(1.05-1.48); and Q4=1.62(1.34-1.96) [P for trend <0.001]. Finally, for the full model the ORs were Q2= 1.04 (0.88-1.23); Q3= 1.05 (0.88-1.26) and Q4= 1.32(1.08-1.62) [P for trend <0. 01]. Conclusion: Uric acid levels were correlated to prehypertension among a middle-aged urban population. It occurred independently of other variables classically associated to high blood pressure or the origin of higher uric acid in hominids.

scholarly journals Genetic and Environmental Influences on Cardiovascular Disease Risk Factors: A Study of Chinese Twin Children and Adolescents

2014 ◽  
Vol 17 (2) ◽  
pp. 72-79 ◽  
Author(s):  
Fuling Ji ◽  
Feng Ning ◽  
Haiping Duan ◽  
Jaakko Kaprio ◽  
Dongfeng Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Waist Circumference ◽  
Body Mass ◽  
Environmental Variance ◽  
Waist To Hip Ratio ◽  
Metabolic Traits ◽  
High Heritability

We evaluated the genetic and environmental contributions to metabolic cardiovascular risk factors and their mutual associations. Eight metabolic factors (body mass index, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, total serum cholesterol, serum triglycerides, and serum uric acid) were measured in 508 twin pairs aged 8–17 years from the Qingdao Twin Registry, China. Linear structural equation models were used to estimate the heritability of these traits, as well as the genetic and environmental correlations between them. Among boys, body mass index and uric acid showed consistently high heritability (0.49–0.81), whereas other traits showed moderate to high common environmental variance (0.37–0.73) in children (8–12 years) and adolescents (13–17 years) except total cholesterol. For girls, moderate to high heritability (0.39–0.75) were obtained for six metabolic traits in children, while only two traits showed high heritability and others mostly medium to large common environmental variance in adolescents. Genetic correlations between the traits were strong in both boys and girls in children (rg = 0.64–0.99 between body mass index and diastolic blood pressure; rg = 0.71–1.00 between body mass index and waist circumference), but decreased for adolescent girls (rg = 0.51 between body mass index and waist-to-hip ratio; rg = 0.55 between body mass index and uric acid; rg = 0.61 between body mass index and systolic blood pressure). The effect of genetic factors on most metabolic traits decreased from childhood to adolescence. Both common genetic and specific environmental factors influence the mutual associations among most of the metabolic traits.

scholarly journals A correlative study of body mass index with oxidative stress parameters (serum uric acid and serum malondialdihyde) in essential hypertension

2019 ◽  
Vol 7 (4) ◽  
pp. 1252 ◽  
Author(s):  
Chanchal Shrivastav ◽  
Paras Arvindbhai Parekh ◽  
G. Indra Kumar
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Oxidative Stress Marker ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Background: Hypertension is most commonly documented modifiable risk factor for cardiovascular diseases. A growing body of data proposes an appreciated pathogenic role of an elevated serum uric acid in atherosclerosis and cardiovascular disease (CVD). Increased oxidative stress could be involved in the pathogenesis of hypertension. Oxidative stress marker, serum uric acid (SUA) and serum malondialdyhyde level (S. MDA) are affected by both genetic and environmental factors and related to biological factors as gender, age and body mass. So, the aim of the study is to access the association of body mass index (BMI) with oxidative stress parameters in essential hypertension (EHT).Methods: For the said purpose, this case control study was carried out on a total of 200, age and sex matched 75 hypertensives, 75 prehypertensive and 50 healthy subjects. After diagnosis of cases, SUA was estimated by standard kit method and S. MDA was estimated manually by Buege and Aust method.Results: This study represents that systolic and diastolic blood pressure were increased with increased BMI in all groups. Oxidative stress marker, SUA and S. MDA level increased significantly with increasing BMI in all groups and were positively correlated.Conclusions: Our study indicates that monitoring of the blood pressure, SUA and S. MDA at regular interval and maintaining of the oxidative balance would be helpful in preventing the development of hypertension and associated cardio-vascular morbidities.

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